Rbm24 RNA binding motif protein 24 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rbm24provided by MGI
Official Full Name: RNA binding motif protein 24provided by MGI
Primary source: MGI:MGI:3610364
See related: Ensembl:ENSMUSG00000038132 AllianceGenome:MGI:3610364
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 6330546B05Rik
Summary: Enables mRNA 3'-UTR binding activity and pre-mRNA intronic binding activity. Involved in endocardial cushion development; positive regulation of skeletal muscle fiber differentiation; and regulation of mRNA metabolic process. Located in cytoplasm. Is expressed in several structures, including embryo mesenchyme; genitourinary system; limb bud; musculature; and sensory organ. Used to study dilated cardiomyopathy. Orthologous to human RBM24 (RNA binding motif protein 24). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in heart adult (RPKM 43.8), bladder adult (RPKM 10.5) and 17 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 A5; 13 23.61 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (46571664..46584575)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (46418102..46431099)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Rbm24/Notch1 signaling regulates adult neurogenesis in the subventricular zone and mediates Parkinson-associated olfactory dysfunction.
Title: Rbm24/Notch1 signaling regulates adult neurogenesis in the subventricular zone and mediates Parkinson-associated olfactory dysfunction.
Deciphering the genetic interactions between Pou4f3, Gfi1, and Rbm24 in maintaining mouse cochlear hair cell survival.
Title: Deciphering the genetic interactions between Pou4f3, Gfi1, and Rbm24 in maintaining mouse cochlear hair cell survival.
RBM24 is required for mouse hair cell development through regulating pre-mRNA alternative splicing and mRNA stability.
Title: RBM24 is required for mouse hair cell development through regulating pre-mRNA alternative splicing and mRNA stability.
RBM24 controls cardiac QT interval through CaMKIIdelta splicing.
Title: RBM24 controls cardiac QT interval through CaMKIIδ splicing.
RBM24 is localized to stress granules in cells under various stress conditions.
Title: RBM24 is localized to stress granules in cells under various stress conditions.
RNA-binding protein RBM24 represses colorectal tumourigenesis by stabilising PTEN mRNA.
Title: RNA-binding protein RBM24 represses colorectal tumourigenesis by stabilising PTEN mRNA.
Rbm24 displays dynamic functions required for myogenic differentiation during muscle regeneration.
Title: Rbm24 displays dynamic functions required for myogenic differentiation during muscle regeneration.
Alternative Splicing of Cdh23 Exon 68 Is Regulated by RBM24, RBM38, and PTBP1.
Title: Alternative Splicing of Cdh23 Exon 68 Is Regulated by RBM24, RBM38, and PTBP1.
Rbm24 modulates adult skeletal muscle regeneration via regulation of alternative splicing.
Title: Rbm24 modulates adult skeletal muscle regeneration via regulation of alternative splicing.
The authors show that RBM24-dependent RNA splicing is an important post-transcriptional regulatory circuit in postnatal heart, which has a significant role in the pathogenesis of dilated cardiomyopathy.
Title: RNA binding protein 24 deletion disrupts global alternative splicing and causes dilated cardiomyopathy.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables mRNA 3'-UTR AU-rich region binding	ISO Inferred from Sequence Orthology more info
enables mRNA 3'-UTR AU-rich region binding	ISS Inferred from Sequence or Structural Similarity more info
enables mRNA 3'-UTR binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA 3'-UTR binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA 3'-UTR binding	ISO Inferred from Sequence Orthology more info
enables mRNA CDS binding	ISO Inferred from Sequence Orthology more info
enables mRNA CDS binding	ISS Inferred from Sequence or Structural Similarity more info
enables pre-mRNA intronic binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific mRNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific mRNA binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in 3'-UTR-mediated mRNA destabilization	ISO Inferred from Sequence Orthology more info
involved_in 3'-UTR-mediated mRNA destabilization	ISS Inferred from Sequence or Structural Similarity more info
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in DNA damage response	ISS Inferred from Sequence or Structural Similarity more info
involved_in RNA splicing	IEA Inferred from Electronic Annotation more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in endocardial cushion development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA destabilization	ISO Inferred from Sequence Orthology more info
involved_in mRNA destabilization	ISS Inferred from Sequence or Structural Similarity more info
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in mRNA stabilization	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA stabilization	ISO Inferred from Sequence Orthology more info
involved_in mRNA stabilization	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cytoplasmic translation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cytoplasmic translation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of 3'-UTR-mediated mRNA stabilization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of 3'-UTR-mediated mRNA stabilization	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of myoblast differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of myotube differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of myotube differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of myotube differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of skeletal muscle fiber differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of stem cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of stem cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of alternative mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of alternative mRNA splicing, via spliceosome	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of alternative mRNA splicing, via spliceosome	ISO Inferred from Sequence Orthology more info
involved_in regulation of alternative mRNA splicing, via spliceosome	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of mRNA stability	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of myotube differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: RNA-binding protein 24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081425.1 → NP_001074894.1 RNA-binding protein 24

See identical proteins and their annotated locations for NP_001074894.1

Status: PROVISIONAL

Source sequence(s)

AC124411

Consensus CDS

CCDS36651.1

UniProtKB/Swiss-Prot

D3Z4I3

Related

ENSMUSP00000043120.4, ENSMUST00000037923.5

Conserved Domains (1) summary

cd12384
Location:11 → 86

RRM_RBM24_RBM38_like; RNA recognition motif (RRM) found in eukaryotic RNA-binding protein RBM24, RBM38 and similar proteins