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    GCN3 translation initiation factor eIF2B subunit alpha [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853896, updated on 9-Dec-2024

    Summary

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    Official Symbol
    GCN3
    Official Full Name
    translation initiation factor eIF2B subunit alpha
    Primary source
    SGD:S000001734
    Locus tag
    YKR026C
    See related
    AllianceGenome:SGD:S000001734; FungiDB:YKR026C; VEuPathDB:YKR026C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    AAS2
    Summary
    Enables enzyme regulator activity and translation initiation factor activity. Contributes to guanyl-nucleotide exchange factor activity. Involved in positive regulation of cellular response to amino acid starvation; positive regulation of cellular response to heat; and positive regulation of translational initiation. Located in cytosol. Part of eukaryotic translation initiation factor 2B complex and guanyl-nucleotide exchange factor complex. Used to study leukoencephalopathy with vanishing white matter. Human ortholog(s) of this gene implicated in leukoencephalopathy with vanishing white matter 1. Orthologous to human EIF2B1 (eukaryotic translation initiation factor 2B subunit alpha). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See GCN3 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (488738..489655, complement)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene putative ATP-dependent RNA helicase Neighboring gene DNA-directed RNA polymerase III subunit C37 Neighboring gene tRNA-Arg Neighboring gene Bch2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Gcn2p regulates a G1/S cell cycle checkpoint in response to DNA damage. Menacho-Marquez M, et al. Cell Cycle, 2007 Sep 15. PMID 17890903
    2. gcd12 mutations are gcn3-dependent alleles of GCD2, a negative regulator of GCN4 in the general amino acid control of Saccharomyces cerevisiae. Paddon CJ, et al. Genetics, 1989 Jul. PMID 2668116, Free PMC Article
    3. Reorganization of budding yeast cytoplasm upon energy depletion. Marini G, et al. Mol Biol Cell, 2020 Jun 1. PMID 32293990, Free PMC Article
    4. Molecular cloning and characterization of cDNA encoding the alpha subunit of the rat protein synthesis initiation factor eIF-2B. Flowers KM, et al. Proc Natl Acad Sci U S A, 1995 May 9. PMID 7753796, Free PMC Article
    5. Filament formation by the translation factor eIF2B regulates protein synthesis in starved cells. Nüske E, et al. Biol Open, 2020 Jul 8. PMID 32554487, Free PMC Article

    See all (101) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Maintenance of inhibition required GCN-dependent hyperphosphorylation of eIF2alpha
      Title: Inhibition of translation initiation by volatile anesthetics involves nutrient-sensitive GCN-independent and -dependent processes in yeast.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables enzyme regulator activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables enzyme regulator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    contributes_to guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables translation initiation factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation initiation factor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of cellular response to amino acid starvation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of cellular response to amino acid starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cellular response to heat IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of translational initiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of translational initiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of translational initiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of translational initiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of translational initiation IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translational initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of eukaryotic translation initiation factor 2B complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of eukaryotic translation initiation factor 2B complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of eukaryotic translation initiation factor 2B complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    part_of eukaryotic translation initiation factor 2B complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of guanyl-nucleotide exchange factor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    translation initiation factor eIF2B subunit alpha
    NP_012951.1
    • Alpha subunit of translation initiation factor eIF2B (eIF2Balpha); guanine-nucleotide exchange factor for eIF2; mutations in eIF2Balpha alter localization of eIF2B; activity regulated by phosphorylated eIF2; positive regulator of GCN4 expression; mutations in human ortholog EIF2B2 cause fatal brain disease childhood ataxia with central nervous system hypomyelination (CACH); human ortholog EIF2B1 can complement yeast null mutant

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      488738..489655 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179816.1 → NP_012951.1  TPA: translation initiation factor eIF2B subunit alpha [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012951.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VX91, P14741
      UniProtKB/TrEMBL
      A6ZZZ0, B3LRB0, B5VMH4, C7GNN3, C8ZCJ0, G2WI57, N1P2N5
      Conserved Domains (1) summary
      COG1184
      Location:1 → 304
      GCD2; Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P14741.1

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