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    RCE1 CAAX prenyl protease [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855317, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RCE1
    Official Full Name
    CAAX prenyl protease
    Primary source
    SGD:S000004887
    Locus tag
    YMR274C
    See related
    AllianceGenome:SGD:S000004887; FungiDB:YMR274C; VEuPathDB:YMR274C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables metalloendopeptidase activity. Involved in CAAX-box protein processing and peptide mating pheromone maturation involved in positive regulation of conjugation with cellular fusion. Located in endoplasmic reticulum membrane. Orthologous to human RCE1 (Ras converting CAAX endopeptidase 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RCE1 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (814364..815311, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Zds1p Neighboring gene ubiquitin-ubiquitin ligase BUL1 Neighboring gene ubiquitin domain-containing protein DSK2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Small-molecule inhibitors of the Rce1p CaaX protease. Manandhar SP, et al. J Biomol Screen, 2007 Oct. PMID 17942791, Free PMC Article
    2. Topology of the yeast Ras converting enzyme as inferred from cysteine accessibility studies. Hildebrandt ER, et al. Biochemistry, 2013 Sep 24. PMID 23972033, Free PMC Article
    3. Photoaffinity labeling of Ras converting enzyme using peptide substrates that incorporate benzoylphenylalanine (Bpa) residues: improved labeling and structural implications. Kyro K, et al. Bioorg Med Chem, 2011 Dec 15. PMID 22079863, Free PMC Article
    4. Protein prenylation, et cetera: signal transduction in two dimensions. Gelb MH. Science, 1997 Mar 21. PMID 9122679
    5. Endoplasmic reticulum membrane localization of Rce1p and Ste24p, yeast proteases involved in carboxyl-terminal CAAX protein processing and amino-terminal a-factor cleavage. Schmidt WK, et al. Proc Natl Acad Sci U S A, 1998 Sep 15. PMID 9736709, Free PMC Article

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the ras converting enzyme requires its glutamate and histidine residues
      Title: Mutational analysis of the ras converting enzyme reveals a requirement for glutamate and histidine residues.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloendopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in CAAX-box protein maturation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in CAAX-box protein processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in CAAX-box protein processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in CAAX-box protein processing IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in CAAX-box protein processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in peptide mating pheromone maturation involved in positive regulation of conjugation with cellular fusion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in peptide mating pheromone maturation involved in positive regulation of conjugation with cellular fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to pheromone IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    CAAX prenyl protease
    NP_014001.1
    • Type II CAAX prenyl protease; involved in the proteolysis and maturation of Ras and the a-factor mating pheromone

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      814364..815311 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182781.1 → NP_014001.1  TPA: CAAX prenyl protease [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014001.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0A1, Q03530
      UniProtKB/TrEMBL
      B3LMG2, B5VQ40, C7GTM5, C8ZFE1
      Conserved Domains (1) summary
      pfam02517
      Location:143 → 254
      Abi; CAAX protease self-immunity
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03530.1

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