MTQ2 S-adenosylmethionine-dependent methyltransferase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: MTQ2
Official Full Name: S-adenosylmethionine-dependent methyltransferase
Primary source: SGD:S000002547
Locus tag: YDR140W
See related: AllianceGenome:SGD:S000002547; FungiDB:YDR140W; VEuPathDB:YDR140W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables S-adenosylmethionine-dependent methyltransferase activity and protein methyltransferase activity. Involved in peptidyl-glutamine methylation; regulation of translation; and ribosomal large subunit biogenesis. Located in cytoplasm and nucleus. Part of eRF1 methyltransferase complex and large ribosomal subunit. Orthologous to human N6AMT1 (N-6 adenine-specific DNA methyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See MTQ2 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (734138..734803)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The catalytic activity of the translation termination factor methyltransferase Mtq2-Trm112 complex is required for large ribosomal subunit biogenesis.
Title: The catalytic activity of the translation termination factor methyltransferase Mtq2-Trm112 complex is required for large ribosomal subunit biogenesis.
the natural substrate of the methyltransferase YDR140w is the ternary complex eRF1.eRF3.GTP
Title: The glutamine residue of the conserved GGQ motif in Saccharomyces cerevisiae release factor eRF1 is methylated by the product of the YDR140w gene.
Mtq2p methylates Sup45p the mtq2-Delta had multiple phenotypes, including cold sensitivity and sensitivity to translation fidelity antibiotics paromomycin and geneticin, to high salt and calcium concentrations, to polymyxin B, and to caffeine
Title: The yeast translation release factors Mrf1p and Sup45p (eRF1) are methylated, respectively, by the methyltransferases Mtq1p and Mtq2p.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables S-adenosylmethionine-dependent methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables S-adenosylmethionine-dependent methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables S-adenosylmethionine-dependent methyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
contributes_to protein methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein-(glutamine-N5) methyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in methylation	IEA Inferred from Electronic Annotation more info
involved_in peptidyl-glutamine methylation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of translation	IDA Inferred from Direct Assay more info	PubMed
involved_in ribosomal large subunit biogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of eRF1 methyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of eRF1 methyltransferase complex	IPI Inferred from Physical Interaction more info	PubMed
part_of large ribosomal subunit	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	HDA more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: S-adenosylmethionine-dependent methyltransferase

NP_010424.3

EC 2.1.1.297

S-adenosylmethionine-dependent methyltransferase; subunit of complex with Trm112p that methylates translation release factor Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; similar to E.coli PrmC; member of the seven beta-strand family

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

734138..734803

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180447.3 → NP_010424.3 TPA: S-adenosylmethionine-dependent methyltransferase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010424.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VSC3, Q03920

UniProtKB/TrEMBL

A6ZYA0, B3LGD9, B5VG35, C7GIP5, C8Z556, G2WAP0, N1PAE1

Conserved Domains (1) summary

cl17173
Location:12 → 221

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...