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    RPL11A ribosomal 60S subunit protein L11A [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856217, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RPL11A
    Official Full Name
    ribosomal 60S subunit protein L11A
    Primary source
    SGD:S000006306
    Locus tag
    YPR102C
    See related
    AllianceGenome:SGD:S000006306; FungiDB:YPR102C; VEuPathDB:YPR102C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable RNA binding activity. Predicted to be a structural constituent of ribosome. Involved in ribosomal large subunit assembly. Part of cytosolic large ribosomal subunit. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia 7 and T-cell acute lymphoblastic leukemia. Orthologous to human RPL11 (ribosomal protein L11). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RPL11A in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (731224..731748, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene mitochondrial 54S ribosomal protein MRPL51 Neighboring gene Snt309p Neighboring gene proteasome core particle subunit beta 5 Neighboring gene Fhl1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A flexible loop in yeast ribosomal protein L11 coordinates P-site tRNA binding. Rhodin MH, et al. Nucleic Acids Res, 2010 Dec. PMID 20705654, Free PMC Article
    2. Functional analysis of the uL11 protein impact on translational machinery. Wawiórka L, et al. Cell Cycle, 2016. PMID 26939941, Free PMC Article
    3. Structural dynamics of the yeast Shwachman-Diamond syndrome protein (Sdo1) on the ribosome and its implication in the 60S subunit maturation. Ma C, et al. Protein Cell, 2016 Mar. PMID 26850260, Free PMC Article
    4. The central core region of yeast ribosomal protein L11 is important for subunit joining and translational fidelity. Rhodin MH, et al. Mol Genet Genomics, 2011 Jun. PMID 21519857, Free PMC Article
    5. Depletion of yeast ribosomal proteins L16 or rp59 disrupts ribosome assembly. Moritz M, et al. J Cell Biol, 1990 Dec. PMID 2277060, Free PMC Article

    See all (93) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables rRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IC
    Inferred by Curator
    more info
    		 PubMed 
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasmic translation IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in ribosomal large subunit assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of cytosolic large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic large ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ribosomal 60S subunit protein L11A
    NP_015427.1
    • Ribosomal 60S subunit protein L11A; expressed at twice the level of Rpl11Bp; involved in ribosomal assembly; depletion causes degradation of 60S proteins and RNA; homologous to mammalian ribosomal protein L11 and bacterial L5; RPL11A has a paralog, RPL11B, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      731224..731748 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184199.1 → NP_015427.1  TPA: ribosomal 60S subunit protein L11A [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015427.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W4A0, P06380, P0C0W9
      UniProtKB/TrEMBL
      A6ZWY2, B3LK66, C8ZJC4, G2WPR8
      Conserved Domains (1) summary
      PTZ00156
      Location:2 → 172
      PTZ00156; 60S ribosomal protein L11; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0C0W9.2

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