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    MAP2K6 mitogen-activated protein kinase kinase 6 [ Homo sapiens (human) ]

    Gene ID: 5608, updated on 4-Jan-2025

    Summary

    Official Symbol
    MAP2K6provided by HGNC
    Official Full Name
    mitogen-activated protein kinase kinase 6provided by HGNC
    Primary source
    HGNC:HGNC:6846
    See related
    Ensembl:ENSG00000108984 MIM:601254; AllianceGenome:HGNC:6846
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MEK6; MKK6; MAPKK6; PRKMK6; SAPKK3; SAPKK-3
    Summary
    This gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in colon (RPKM 5.8), small intestine (RPKM 1.8) and 22 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See MAP2K6 in Genome Data Viewer
    Location:
    17q24.3
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (69414697..69553865)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (70291653..70430810)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (67410838..67550006)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371878 Neighboring gene uncharacterized LOC124900401 Neighboring gene uncharacterized LOC105371879 Neighboring gene Sharpr-MPRA regulatory region 9140 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:67425744-67426560 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12654 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:67443780-67444760 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:67444761-67445742 Neighboring gene uncharacterized LOC105371880 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12655 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12656 Neighboring gene NANOG hESC enhancer GRCh37_chr17:67502478-67502979 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12657 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12658 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:67565237-67565738 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr17:67603079-67604278 Neighboring gene long intergenic non-protein coding RNA 1483 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr17:67757718-67758917 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:67797333-67798295 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:67798296-67799257 Neighboring gene MPRA-validated peak2972 silencer Neighboring gene MPRA-validated peak2973 silencer Neighboring gene long intergenic non-protein coding RNA 1497

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (19 hits/1300 screens)

    EBI GWAS Catalog

    Description
    Genome-wide association study of peripheral neuropathy with D-drug-containing regimens in AIDS Clinical Trials Group protocol 384.
    EBI GWAS Catalog
    Investigation of single nucleotide polymorphisms and biological pathways associated with response to TNFα inhibitors in patients with rheumatoid arthritis.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat The interaction of HIV-1 Tat with cellular transcription factors CDK9 and Sp1 is required for Tat activation of MAP2K3-, MAP2K6-, and IRF7-mediated luciferase transcription PubMed
    tat The association of HIV-1 Tat with MAP2K6 promoter leads to the activation of this kinase in immature dendritic cells and in monocyte-derived macrophages PubMed
    tat MAP2K6 and IRF7 induce HIV-1 Tat-mediated cellular gene modulation through the p38 MAPK/STAT1 pathway in immature dendritic cells and in monocyte-derived macrophages PubMed
    tat SiRNA-mediated inhibition of MAP2K6 and MAP2K3 reduces HIV-1 Tat-induced modulation of interferon (IFN)-stimulated genes in immature dendritic cells and in monocyte-derived macrophages PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding  
    enables JUN kinase kinase activity  
    enables MAP kinase kinase activity  
    enables MAP kinase kinase activity PubMed 
    enables MAP kinase kinase activity  
    enables histone H2AXY142 kinase activity  
    enables histone H3Y41 kinase activity  
    enables identical protein binding PubMed 
    enables protein binding PubMed 
    enables protein kinase binding PubMed 
    enables protein serine kinase activity  
    enables protein serine/threonine kinase activity  
    Items 1 - 25 of 26
    Process Evidence Code Pubs
    involved_in JNK cascade  
    involved_in MAPK cascade  
    involved_in MAPK cascade PubMed 
    involved_in apoptotic process  
    involved_in bone development  
    involved_in cardiac muscle contraction  
    involved_in cellular response to sorbitol  
    involved_in cellular senescence  
    involved_in chromatin remodeling  
    involved_in negative regulation of cold-induced thermogenesis PubMed 
    involved_in nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway  
    involved_in osteoblast differentiation  
    involved_in ovulation cycle process  
    involved_in p38MAPK cascade PubMed 
    involved_in p38MAPK cascade  
    involved_in positive regulation of MAPK cascade  
    involved_in positive regulation of apoptotic process  
    involved_in positive regulation of prostaglandin secretion  
    involved_in regulation of cell cycle PubMed 
    involved_in regulation of signal transduction by p53 class mediator  
    involved_in response to ischemia  
    involved_in response to xenobiotic stimulus  
    involved_in signal transduction PubMed 
    involved_in signal transduction in response to DNA damage PubMed 
    involved_in stress-activated MAPK cascade PubMed 
    involved_in stress-activated protein kinase signaling cascade PubMed 
    Items 1 - 25 of 26
    Component Evidence Code Pubs
    is_active_in cytoplasm PubMed 
    located_in cytoskeleton  
    is_active_in cytosol PubMed 
    located_in cytosol  
    located_in cytosol  
    located_in nucleoplasm  
    located_in nucleoplasm  

    General protein information

    Preferred Names
    dual specificity mitogen-activated protein kinase kinase 6
    Names
    MAPK/ERK kinase 6
    MAPKK 6
    MEK 6
    SAPK kinase 3
    protein kinase, mitogen-activated, kinase 6 (MAP kinase kinase 6)
    stress-activated protein kinase kinase 3
    NP_001317379.1
    NP_002749.2
    XP_005257573.1
    XP_006722038.1
    XP_011523329.1
    XP_047292366.1
    XP_047292367.1
    XP_054172660.1
    XP_054172661.1
    XP_054172662.1
    XP_054172663.1
    XP_054172664.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029437.2 RefSeqGene

      Range
      5001..144169
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001330450.2 → NP_001317379.1  dual specificity mitogen-activated protein kinase kinase 6 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC002546, BC037328
      Consensus CDS
      CCDS82194.1
      UniProtKB/TrEMBL
      B5BU16
      Related
      ENSP00000467213.1, ENST00000589647.5
      Conserved Domains (1) summary
      cd06617
      Location:1 → 277
      PKc_MKK3_6; Catalytic domain of the dual-specificity Protein Kinases, Mitogen-activated protein Kinase Kinases 3 and 6
    2. NM_002758.4 → NP_002749.2  dual specificity mitogen-activated protein kinase kinase 6 isoform 1

      See identical proteins and their annotated locations for NP_002749.2

      Status: REVIEWED

      Source sequence(s)
      AA932919, AC002546, BC012009, DB111443
      Consensus CDS
      CCDS11686.1
      UniProtKB/Swiss-Prot
      P52564
      UniProtKB/TrEMBL
      A8K3Y2, B5BU16
      Related
      ENSP00000468348.1, ENST00000590474.7
      Conserved Domains (1) summary
      cd06617
      Location:51 → 333
      PKc_MKK3_6; Catalytic domain of the dual-specificity Protein Kinases, Mitogen-activated protein Kinase Kinases 3 and 6

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      69414697..69553865
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047436411.1 → XP_047292367.1  dual specificity mitogen-activated protein kinase kinase 6 isoform X2

      UniProtKB/TrEMBL
      B5BU16
    2. XM_011525027.4 → XP_011523329.1  dual specificity mitogen-activated protein kinase kinase 6 isoform X2

      See identical proteins and their annotated locations for XP_011523329.1

      UniProtKB/TrEMBL
      B5BU16
      Conserved Domains (1) summary
      cd06617
      Location:1 → 277
      PKc_MKK3_6; Catalytic domain of the dual-specificity Protein Kinases, Mitogen-activated protein Kinase Kinases 3 and 6
    3. XM_047436410.1 → XP_047292366.1  dual specificity mitogen-activated protein kinase kinase 6 isoform X1

      UniProtKB/TrEMBL
      B5BU16
    4. XM_005257516.3 → XP_005257573.1  dual specificity mitogen-activated protein kinase kinase 6 isoform X2

      See identical proteins and their annotated locations for XP_005257573.1

      UniProtKB/TrEMBL
      B5BU16
      Conserved Domains (1) summary
      cd06617
      Location:1 → 277
      PKc_MKK3_6; Catalytic domain of the dual-specificity Protein Kinases, Mitogen-activated protein Kinase Kinases 3 and 6
    5. XM_006721975.4 → XP_006722038.1  dual specificity mitogen-activated protein kinase kinase 6 isoform X2

      See identical proteins and their annotated locations for XP_006722038.1

      UniProtKB/TrEMBL
      B5BU16
      Conserved Domains (1) summary
      cd06617
      Location:1 → 277
      PKc_MKK3_6; Catalytic domain of the dual-specificity Protein Kinases, Mitogen-activated protein Kinase Kinases 3 and 6

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      70291653..70430810
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054316686.1 → XP_054172661.1  dual specificity mitogen-activated protein kinase kinase 6 isoform X2

      UniProtKB/TrEMBL
      B5BU16
    2. XM_054316687.1 → XP_054172662.1  dual specificity mitogen-activated protein kinase kinase 6 isoform X2

      UniProtKB/TrEMBL
      B5BU16
    3. XM_054316685.1 → XP_054172660.1  dual specificity mitogen-activated protein kinase kinase 6 isoform X1

      UniProtKB/TrEMBL
      B5BU16
    4. XM_054316689.1 → XP_054172664.1  dual specificity mitogen-activated protein kinase kinase 6 isoform X2

      UniProtKB/TrEMBL
      B5BU16
    5. XM_054316688.1 → XP_054172663.1  dual specificity mitogen-activated protein kinase kinase 6 isoform X2

      UniProtKB/TrEMBL
      B5BU16

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