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    PLAAT2 phospholipase A and acyltransferase 2 [ Homo sapiens (human) ]

    Gene ID: 54979, updated on 4-Jan-2025

    Summary

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    Official Symbol
    PLAAT2provided by HGNC
    Official Full Name
    phospholipase A and acyltransferase 2provided by HGNC
    Primary source
    HGNC:HGNC:17824
    See related
    Ensembl:ENSG00000133328 MIM:613866; AllianceGenome:HGNC:17824
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HRASLS2; PLAAT-2; PLA1/2-2
    Summary
    The protein encoded by this gene has both phospholipase and acyltransferase activities and acts as a tumor suppressor. The encoded protein can hydrolyze dipalmitoylated phosphatidylcholine (PC) to palmitic acid and lyso-PC. In addition, this protein can catalyze the N-acylation of phosphatidylethanolamine and can catalyze the O-acylation of lyso-PC to form PC. [provided by RefSeq, Jul 2016]
    Expression
    Biased expression in duodenum (RPKM 16.4), small intestine (RPKM 9.9) and 3 other tissues See more
    Orthologs
    all
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    Genomic context

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    See PLAAT2 in Genome Data Viewer
    Location:
    11q12.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (63552770..63565070, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (63542032..63554332, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (63320242..63330851, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:63295415-63296076 Neighboring gene TMSB4X pseudogene 5 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:63296739-63297398 Neighboring gene Sharpr-MPRA regulatory region 8142 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:63299385-63300044 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4869 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4870 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:63312621-63313820 Neighboring gene phospholipase A and acyltransferase 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4871 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3435 Neighboring gene CRISPRi-validated cis-regulatory element chr11.2897 Neighboring gene uncharacterized LOC105369335 Neighboring gene phospholipase A and acyltransferase 3 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:63368875-63369376 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:63372619-63373384 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr11:63378198-63378707 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:63379461-63379961 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3436 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3437 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:63398741-63399940 Neighboring gene inner mitochondrial membrane peptidase subunit 1 pseudogene 1 Neighboring gene atlastin GTPase 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Cloning and functional characterization of the HRASLS2 gene. Shyu RY, et al. Amino Acids, 2008 Jun. PMID 18163183
    2. Structural basis for the acyltransferase activity of lecithin:retinol acyltransferase-like proteins. Golczak M, et al. J Biol Chem, 2012 Jul 6. PMID 22605381, Free PMC Article
    3. Characterization of the human tumor suppressors TIG3 and HRASLS2 as phospholipid-metabolizing enzymes. Uyama T, et al. Biochim Biophys Acta, 2009 Dec. PMID 19615464
    4. Generation of N-acylphosphatidylethanolamine by members of the phospholipase A/acyltransferase (PLA/AT) family. Uyama T, et al. J Biol Chem, 2012 Sep 14. PMID 22825852, Free PMC Article
    5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. Bailey SD, et al. Diabetes Care, 2010 Oct. PMID 20628086, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that acyl-modified forms of HRAS-like tumor suppressors HRASLS2 and HRASLS3 mimicking lipolytic activity of lecithin retinol acyltransferase LRAT.
      Title: Structural basis for the acyltransferase activity of lecithin:retinol acyltransferase-like proteins.
    2. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
    3. Observational study of gene-disease association. (HuGE Navigator)
      Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
    4. The tumor suppressors TIG3, HRASLS2 and H-rev107 are involved in the phospholipid metabolism with different physiological roles.
      Title: Characterization of the human tumor suppressors TIG3 and HRASLS2 as phospholipid-metabolizing enzymes.
    5. HRASLS2 protein suppressed growth and RAS activities of cancer cells, and the C-terminal hydrophobic domain appeared to be indispensable for both activities.
      Title: Cloning and functional characterization of the HRASLS2 gene.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • FLJ20556

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables N-acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables N-acyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables acyltransferase activity TAS
    Traceable Author Statement
    more info
    		  
    enables calcium-dependent phospholipase A2 activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium-independent phospholipase A2 activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylserine 1-acylhydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phospholipase A1 activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phospholipase A1 activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phospholipase A2 activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phospholipase A2 activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in N-acylphosphatidylethanolamine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in N-acylphosphatidylethanolamine metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphatidylethanolamine acyl-chain remodeling TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    phospholipase A and acyltransferase 2
    Names
    HRAS like suppressor 2
    phospholipase A/acyltransferase-2
    NP_060348.1
    XP_011543422.1
    XP_054225195.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017878.2 → NP_060348.1  phospholipase A and acyltransferase 2

      Status: REVIEWED

      Source sequence(s)
      AK000563
      Consensus CDS
      CCDS8046.1
      UniProtKB/Swiss-Prot
      B9A7L8, Q9NWW9
      Related
      ENSP00000255695.1, ENST00000255695.2
      Conserved Domains (1) summary
      pfam04970
      Location:20 → 125
      LRAT; Lecithin retinol acyltransferase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      63552770..63565070 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011545120.3 → XP_011543422.1  phospholipase A and acyltransferase 2 isoform X1

      Conserved Domains (1) summary
      pfam04970
      Location:53 → 158
      LRAT; Lecithin retinol acyltransferase

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      63542032..63554332 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054369220.1 → XP_054225195.1  phospholipase A and acyltransferase 2 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NWW9.1 GenPept UniProtKB/Swiss-Prot:Q9NWW9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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