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    LTO1 ribosome biosynthesis protein LTO1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855461, updated on 9-Dec-2024

    Summary

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    Official Symbol
    LTO1
    Official Full Name
    ribosome biosynthesis protein LTO1
    Primary source
    SGD:S000005204
    Locus tag
    YNL260C
    See related
    AllianceGenome:SGD:S000005204; FungiDB:YNL260C; VEuPathDB:YNL260C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Contributes to protein-macromolecule adaptor activity. Involved in protein maturation by [4Fe-4S] cluster transfer. Located in nucleus. Part of Yae1-Lto1 complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See LTO1 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (156859..157347, complement)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene DNA polymerase epsilon catalytic subunit Neighboring gene origin recognition complex subunit 5 Neighboring gene copper metallochaperone ATX1 Neighboring gene Dsl1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure of the 40S-ABCE1 post-splitting complex in ribosome recycling and translation initiation. Heuer A, et al. Nat Struct Mol Biol, 2017 May. PMID 28368393
    2. Sequence analysis of the 33 kb long region between ORC5 and SUI1 from the left arm of chromosome XIV from Saccharomyces cerevisiae. Sen-Gupta M, et al. Yeast, 1997 Jul. PMID 9234673
    3. Why does Kluyveromyces lactis not grow under anaerobic conditions? Comparison of essential anaerobic genes of Saccharomyces cerevisiae with the Kluyveromyces lactis genome. Snoek IS, et al. FEMS Yeast Res, 2006 May. PMID 16630279
    4. The function of ORAOV1/LTO1, a gene that is overexpressed frequently in cancer: essential roles in the function and biogenesis of the ribosome. Zhai C, et al. Oncogene, 2014 Jan 23. PMID 23318452
    5. Large-scale analysis of yeast filamentous growth by systematic gene disruption and overexpression. Jin R, et al. Mol Biol Cell, 2008 Jan. PMID 17989363, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Collectively, the Yae1-Lto1 complex functions as a target-specific adaptor that recruits apo-Rli1 to the generic cytosolic iron-sulfur assembly machinery.
      Title: The deca-GX3 proteins Yae1-Lto1 function as adaptors recruiting the ABC protein Rli1 for iron-sulfur cluster insertion.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to protein-macromolecule adaptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to protein-macromolecule adaptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein maturation by [4Fe-4S] cluster transfer IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Yae1-Lto1 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Yae1-Lto1 complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ribosome biosynthesis protein LTO1
    NP_014139.2
    • Substrate-specific adaptor protein involved in apo-Rli1p maturation; subunit of the Yae1-Lto1 complex, recruiting apo-Rli1p to the CIA targeting complex, facilitating the insertion of an Fe/S cluster by the Fe-S biosynthetic machinery; deca-GX3 motif crucial for complex formation; essential for aerobic but not anaerobic growth; homolog of human ORAOV1, which is overexpressed in solid tumors; co-expression of ORAOV1 and YAE1 homolog YAE1D1 restores growth and Rli1p maturation after LTO1 depletion

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      156859..157347 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183098.2 → NP_014139.2  TPA: ribosome biosynthesis protein LTO1 [Saccharomyces cerevisiae S288C]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0T3, P53846
      UniProtKB/TrEMBL
      A6ZRI3, B5VQF1, G2WLK6, N1NZX8
      Conserved Domains (2) summary
      COG3587
      Location:70 → 161
      COG3587; Restriction endonuclease [Defense mechanisms]
      pfam09811
      Location:17 → 55
      Yae1_N; Essential protein Yae1, N terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53846.2

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