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    JEM1 Jem1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853372, updated on 9-Dec-2024

    Summary

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    Official Symbol
    JEM1
    Official Full Name
    Jem1p
    Primary source
    SGD:S000003609
    Locus tag
    YJL073W
    See related
    AllianceGenome:SGD:S000003609; FungiDB:YJL073W; VEuPathDB:YJL073W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    KAR8
    Summary
    Enables protein-folding chaperone binding activity and unfolded protein binding activity. Involved in ERAD pathway; karyogamy involved in conjugation with cellular fusion; and protein folding in endoplasmic reticulum. Located in endoplasmic reticulum and nuclear outer membrane-endoplasmic reticulum membrane network. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See JEM1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (303181..305118)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Net1p Neighboring gene Apq13p Neighboring gene cohesin subunit SMC3 Neighboring gene DNA replication protein PSF2 Neighboring gene acetyl-CoA:L-glutamate N-acetyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Reinvestigation of the functions of the hydrophobic segment of Jem1p, a yeast endoplasmic reticulum membrane protein mediating nuclear fusion. Nishikawa S, et al. Biochem Biophys Res Commun, 1998 Mar 27. PMID 9535743
    2. Nep98p is a component of the yeast spindle pole body and essential for nuclear division and fusion. Nishikawa S, et al. J Biol Chem, 2003 Mar 14. PMID 12493774
    3. Nuclear inner membrane fusion facilitated by yeast Jem1p is required for spindle pole body fusion but not for the first mitotic nuclear division during yeast mating. Nishikawa S, et al. Genes Cells, 2008 Nov. PMID 19090812
    4. The yeast JEM1p is a DnaJ-like protein of the endoplasmic reticulum membrane required for nuclear fusion. Nishikawa S, et al. J Biol Chem, 1997 May 16. PMID 9148890
    5. Dependence of endoplasmic reticulum-associated degradation on the peptide binding domain and concentration of BiP. Kabani M, et al. Mol Biol Cell, 2003 Aug. PMID 12925775, Free PMC Article

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Jem1p facilitates nuclear inner-membrane fusion and spindle pole body (SPB) fusion
      Title: Nuclear inner membrane fusion facilitated by yeast Jem1p is required for spindle pole body fusion but not for the first mitotic nuclear division during yeast mating.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables misfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-folding chaperone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-folding chaperone binding IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables unfolded protein binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ERAD pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in karyogamy involved in conjugation with cellular fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein folding in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding in endoplasmic reticulum IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear outer membrane-endoplasmic reticulum membrane network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Jem1p
    NP_012462.3
    • DnaJ-like chaperone required for nuclear membrane fusion during mating; localizes to the ER membrane; exhibits genetic interactions with KAR2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      303181..305118
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181506.3 → NP_012462.3  TPA: Jem1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012462.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWB0, P40358
      UniProtKB/TrEMBL
      C8ZBE1, N1P337
      Conserved Domains (1) summary
      COG0484
      Location:536 → 644
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40358.3

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