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    TMEM236 transmembrane protein 236 [ Homo sapiens (human) ]

    Gene ID: 653567, updated on 10-Dec-2024

    Summary

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    Official Symbol
    TMEM236provided by HGNC
    Official Full Name
    transmembrane protein 236provided by HGNC
    Primary source
    HGNC:HGNC:23473
    See related
    Ensembl:ENSG00000148483 AllianceGenome:HGNC:23473
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FAM23A; FAM23B; bA16O1.2; bA162I21.2
    Summary
    Predicted to be located in membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Annotation information
    Note: In the NCBI Build 37.2 reference assembly, TMEM236 (FAM23A) and FAM23B are duplicate genes in close proximity to each other on chromosome 10. In July 2010, the Genome Reference Consortium determined that the region contains a duplication error. The clone on which FAM23B was based (AL928729) will be removed from the reference assembly and only TMEM236 will be present in the assembly. [13 Feb 2013]
    Expression
    Biased expression in small intestine (RPKM 7.1), duodenum (RPKM 4.6) and 2 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TMEM236 in Genome Data Viewer
    Location:
    10p12.33
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (17752201..17800868)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (17771505..17820200)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (17794200..17842867)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:17685104-17685752 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:17685753-17686402 Neighboring gene STAM divergent transcript Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:17713088-17713842 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr10:17715682-17716218 Neighboring gene signal transducing adaptor molecule Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:17728822-17729322 Neighboring gene MPRA-validated peak889 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:17829359-17829976 Neighboring gene mannose receptor C-type 1 Neighboring gene microRNA 511 Neighboring gene uncharacterized LOC124902600

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Transcriptome profiling by combined machine learning and statistical R analysis identifies TMEM236 as a potential novel diagnostic biomarker for colorectal cancer. Maurya NS, et al. Sci Rep, 2021 Jul 12. PMID 34253750, Free PMC Article
    2. Genome-wide association study of hematological and biochemical traits in a Japanese population. Kamatani Y, et al. Nat Genet, 2010 Mar. PMID 20139978
    3. The DNA sequence and comparative analysis of human chromosome 10. Deloukas P, et al. Nature, 2004 May 27. PMID 15164054
    4. The sequence of the human genome. Venter JC, et al. Science, 2001 Feb 16. PMID 11181995
    5. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ59050

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 236
    Names
    family with sequence similarity 23, member A
    family with sequence similarity 23, member B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001098844.3 → NP_001092314.1  transmembrane protein 236

      See identical proteins and their annotated locations for NP_001092314.1

      Status: VALIDATED

      Source sequence(s)
      AL139238, BC157856, BX097915
      Consensus CDS
      CCDS41492.1
      UniProtKB/Swiss-Prot
      B2RXH7, Q5W0B7
      Related
      ENSP00000366715.1, ENST00000377495.2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      17752201..17800868
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017016574.2 → XP_016872063.1  transmembrane protein 236 isoform X1

      UniProtKB/TrEMBL
      B4DU14

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      17771505..17820200
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054366644.1 → XP_054222619.1  transmembrane protein 236 isoform X1

      UniProtKB/TrEMBL
      B4DU14

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001013629.1: Suppressed sequence

      Description
      NM_001013629.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5W0B7.1 GenPept UniProtKB/Swiss-Prot:Q5W0B7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials