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    TACC3 transforming acidic coiled-coil containing protein 3 [ Homo sapiens (human) ]

    Gene ID: 10460, updated on 10-Dec-2024

    Summary

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    Official Symbol
    TACC3provided by HGNC
    Official Full Name
    transforming acidic coiled-coil containing protein 3provided by HGNC
    Primary source
    HGNC:HGNC:11524
    See related
    Ensembl:ENSG00000013810 MIM:605303; AllianceGenome:HGNC:11524
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ERIC1; Tacc4; ERIC-1; maskin
    Summary
    This gene encodes a member of the transforming acidic colied-coil protein family. The encoded protein is a motor spindle protein that may play a role in stabilization of the mitotic spindle. This protein may also play a role in growth a differentiation of certain cancer cells. [provided by RefSeq, Nov 2011]
    Expression
    Broad expression in testis (RPKM 25.6), bone marrow (RPKM 24.9) and 16 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TACC3 in Genome Data Viewer
    Location:
    4p16.3
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (1721521..1745171)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (1719323..1742998)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (1723248..1746898)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene stem-loop histone mRNA binding protein Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:1707982-1708482 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15138 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15139 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21155 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21156 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21157 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21158 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21159 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21160 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15140 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:1723083-1724078 Neighboring gene transmembrane protein 129, E3 ubiquitin ligase Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:1732480-1732980 Neighboring gene uncharacterized LOC112268460 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15142 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:1755043-1755650 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:1767895-1768754 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:1769833-1770398 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:1770399-1770964 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15143 Neighboring gene uncharacterized LOC124900648 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:1779273-1780036 Neighboring gene CRISPRi-validated cis-regulatory element chr4.260 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15144 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15145 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:1796986-1797514 Neighboring gene fibroblast growth factor receptor 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. TACC3 overexpression in cholangiocarcinoma correlates with poor prognosis and is a potential anti-cancer molecular drug target for HDAC inhibitors. He JC, et al. Oncotarget, 2016 Nov 15. PMID 27705912, Free PMC Article
    2. TACC3 promotes colorectal cancer tumourigenesis and correlates with poor prognosis. Du Y, et al. Oncotarget, 2016 Jul 5. PMID 27248823, Free PMC Article
    3. Transforming acidic coiled-coil protein-3: a novel marker for differential diagnosis and prognosis prediction in endocervical adenocarcinoma. Wen YL, et al. Mol Med, 2021 Jun 10. PMID 34134633, Free PMC Article
    4. The transforming acidic coiled coil 3 protein is essential for spindle-dependent chromosome alignment and mitotic survival. Schneider L, et al. J Biol Chem, 2007 Oct 5. PMID 17675670
    5. TACC3 is a prognostic biomarker for kidney renal clear cell carcinoma and correlates with immune cell infiltration and T cell exhaustion. Fan X, et al. Aging (Albany NY), 2021 Mar 10. PMID 33714201, Free PMC Article

    See all (148) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cellular senescence gene TACC3 associated with colorectal cancer risk via genetic and DNA methylated alteration.
      Title: Cellular senescence gene TACC3 associated with colorectal cancer risk via genetic and DNA methylated alteration.
    2. Non-Small Cell Lung Carcinoma With Clear Cell Features and FGFR3::TACC3 Gene Rearrangement : Clinicopathologic and Next Generation Sequencing Study of 7 Cases.
      Title: Non-Small Cell Lung Carcinoma With Clear Cell Features and FGFR3::TACC3 Gene Rearrangement : Clinicopathologic and Next Generation Sequencing Study of 7 Cases.
    3. TACC3 is an independent prognostic marker, and knockdown of TACC3 enhances the efficacy of CDK1 inhibitor RO3306 in liver cancer cells.
      Title: TACC3 is an independent prognostic marker, and knockdown of TACC3 enhances the efficacy of CDK1 inhibitor RO3306 in liver cancer cells.
    4. Targeting TACC3 represents a novel vulnerability in highly aggressive breast cancers with centrosome amplification.
      Title: Targeting TACC3 represents a novel vulnerability in highly aggressive breast cancers with centrosome amplification.
    5. TACC3-ch-TOG interaction regulates spindle microtubule assembly by controlling centrosomal recruitment of gamma-TuRC.
      Title: TACC3-ch-TOG interaction regulates spindle microtubule assembly by controlling centrosomal recruitment of γ-TuRC.
    6. Oncogenic driver FGFR3-TACC3 requires five coiled-coil heptads for activation and disulfide bond formation for stability.
      Title: Oncogenic driver FGFR3-TACC3 requires five coiled-coil heptads for activation and disulfide bond formation for stability.
    7. Elevated expression of transforming acidic coiled-coil-containing protein 3 (TACC3) reflects aggressiveness of primary central nervous system lymphomas.
      Title: Elevated expression of transforming acidic coiled-coil-containing protein 3 (TACC3) reflects aggressiveness of primary central nervous system lymphomas.
    8. High Expression of TACC3 Is Associated with the Poor Prognosis and Immune Infiltration in Lung Adenocarcinoma Patients.
      Title: High Expression of TACC3 Is Associated with the Poor Prognosis and Immune Infiltration in Lung Adenocarcinoma Patients.
    9. Transforming acidic coiled-coil protein-3: a novel marker for differential diagnosis and prognosis prediction in endocervical adenocarcinoma.
      Title: Transforming acidic coiled-coil protein-3: a novel marker for differential diagnosis and prognosis prediction in endocervical adenocarcinoma.
    10. TACC3 is a prognostic biomarker for kidney renal clear cell carcinoma and correlates with immune cell infiltration and T cell exhaustion.
      Title: TACC3 is a prognostic biomarker for kidney renal clear cell carcinoma and correlates with immune cell infiltration and T cell exhaustion.
    Submit: New GeneRIF Correction See all GeneRIFs (76)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci.
    EBI GWAS Catalog
    A sequence variant at 4p16.3 confers susceptibility to urinary bladder cancer.
    EBI GWAS Catalog
    Genome-wide association study identifies multiple loci associated with bladder cancer risk.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC117382, MGC133242

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cerebral cortex development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in metaphase/anaphase transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule cytoskeleton organization involved in mitosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic spindle organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nuclear migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of mitotic spindle organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in centriolar satellite IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		  
    located_in mitotic spindle IDA
    Inferred from Direct Assay
    more info
    		  
    located_in spindle pole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transforming acidic coiled-coil-containing protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_064424.1 RefSeqGene

      Range
      5032..28682
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_1367

    mRNA and Protein(s)

    1. NM_001410699.1 → NP_001397628.1  transforming acidic coiled-coil-containing protein 3 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC016773
      Consensus CDS
      CCDS93465.1
      UniProtKB/TrEMBL
      A0A087WUE2
      Related
      ENSP00000478580.2, ENST00000612220.5

    2. NM_006342.3 → NP_006333.1  transforming acidic coiled-coil-containing protein 3 isoform 1

      See identical proteins and their annotated locations for NP_006333.1

      Status: REVIEWED

      Source sequence(s)
      AF093543, AI684124, DB098941
      Consensus CDS
      CCDS3352.1
      UniProtKB/Swiss-Prot
      Q2NKK4, Q3KQS5, Q9UMQ1, Q9Y6A5
      UniProtKB/TrEMBL
      A0A494BZT8
      Related
      ENSP00000326550.4, ENST00000313288.9
      Conserved Domains (2) summary
      pfam05010
      Location:639 → 832
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
      cl23765
      Location:652 → 753
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      1721521..1745171
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017007653.2 → XP_016863142.1  transforming acidic coiled-coil-containing protein 3 isoform X2

      UniProtKB/Swiss-Prot
      Q2NKK4, Q3KQS5, Q9UMQ1, Q9Y6A5
      UniProtKB/TrEMBL
      A0A494BZT8
      Conserved Domains (2) summary
      pfam05010
      Location:639 → 832
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
      cl23765
      Location:652 → 753
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

    2. XM_005247929.4 → XP_005247986.1  transforming acidic coiled-coil-containing protein 3 isoform X1

      UniProtKB/TrEMBL
      A0A494BZT8
      Conserved Domains (2) summary
      pfam05010
      Location:639 → 836
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
      cl23765
      Location:656 → 757
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

    3. XM_005247930.4 → XP_005247987.1  transforming acidic coiled-coil-containing protein 3 isoform X5

      Conserved Domains (1) summary
      pfam05010
      Location:279 → 476
      TACC; Transforming acidic coiled-coil-containing protein (TACC)

    4. XM_011513386.4 → XP_011511688.1  transforming acidic coiled-coil-containing protein 3 isoform X3

      UniProtKB/TrEMBL
      B4DYJ1
      Conserved Domains (2) summary
      PRK12323
      Location:239 → 482
      PRK12323; DNA polymerase III subunits gamma and tau; Provisional
      pfam05010
      Location:639 → 691
      TACC; Transforming acidic coiled-coil-containing protein (TACC)

    5. XM_047449523.1 → XP_047305479.1  transforming acidic coiled-coil-containing protein 3 isoform X4

      UniProtKB/TrEMBL
      B4DYJ1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      1719323..1742998
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054348765.1 → XP_054204740.1  transforming acidic coiled-coil-containing protein 3 isoform X2

      UniProtKB/Swiss-Prot
      Q2NKK4, Q3KQS5, Q9UMQ1, Q9Y6A5
      UniProtKB/TrEMBL
      A0A494BZT8

    2. XM_054348763.1 → XP_054204738.1  transforming acidic coiled-coil-containing protein 3 isoform X1

      UniProtKB/TrEMBL
      A0A494BZT8

    3. XM_054348770.1 → XP_054204745.1  transforming acidic coiled-coil-containing protein 3 isoform X5

    4. XM_054348768.1 → XP_054204743.1  transforming acidic coiled-coil-containing protein 3 isoform X3

      UniProtKB/TrEMBL
      B4DYJ1

    5. XM_054348769.1 → XP_054204744.1  transforming acidic coiled-coil-containing protein 3 isoform X4

      UniProtKB/TrEMBL
      B4DYJ1

    6. XM_054348766.1 → XP_054204741.1  transforming acidic coiled-coil-containing protein 3 isoform X2

      UniProtKB/Swiss-Prot
      Q2NKK4, Q3KQS5, Q9UMQ1, Q9Y6A5
      UniProtKB/TrEMBL
      A0A494BZT8

    7. XM_054348767.1 → XP_054204742.1  transforming acidic coiled-coil-containing protein 3 isoform X2

      UniProtKB/Swiss-Prot
      Q2NKK4, Q3KQS5, Q9UMQ1, Q9Y6A5
      UniProtKB/TrEMBL
      A0A494BZT8

    8. XM_054348764.1 → XP_054204739.1  transforming acidic coiled-coil-containing protein 3 isoform X1

      UniProtKB/TrEMBL
      A0A494BZT8
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Y6A5.1 GenPept UniProtKB/Swiss-Prot:Q9Y6A5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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