U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    DNAJC2 DnaJ heat shock protein family (Hsp40) member C2 [ Homo sapiens (human) ]

    Gene ID: 27000, updated on 10-Dec-2024

    Summary

    Official Symbol
    DNAJC2provided by HGNC
    Official Full Name
    DnaJ heat shock protein family (Hsp40) member C2provided by HGNC
    Primary source
    HGNC:HGNC:13192
    See related
    Ensembl:ENSG00000105821 MIM:605502; AllianceGenome:HGNC:13192
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZRF1; ZUO1; MPP11; MPHOSPH11
    Summary
    This gene is a member of the M-phase phosphoprotein (MPP) family. The gene encodes a phosphoprotein with a J domain and a Myb DNA-binding domain which localizes to both the nucleus and the cytosol. The protein is capable of forming a heterodimeric complex that associates with ribosomes, acting as a molecular chaperone for nascent polypeptide chains as they exit the ribosome. This protein was identified as a leukemia-associated antigen and expression of the gene is upregulated in leukemic blasts. Also, chromosomal aberrations involving this gene are associated with primary head and neck squamous cell tumors. This gene has a pseudogene on chromosome 6. Alternatively spliced variants which encode different protein isoforms have been described. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in bone marrow (RPKM 19.0), testis (RPKM 17.8) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See DNAJC2 in Genome Data Viewer
    Location:
    7q22.1
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (103312289..103344767, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (104626740..104659211, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (102952736..102985214, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375434 Neighboring gene ribosomal protein L23a pseudogene 95 Neighboring gene DPY19L2 pseudogene 2 Neighboring gene S100A11 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26439 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18510 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:102921045-102921566 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26440 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26441 Neighboring gene peptidase, mitochondrial processing subunit beta Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26442 Neighboring gene ribosomal protein S29 pseudogene 16 Neighboring gene solute carrier family 26 member 5 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:103021047-103021334 Neighboring gene proteasome 26S subunit, ATPase 2 Neighboring gene Sharpr-MPRA regulatory region 10264 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:103086027-103086603 Neighboring gene SLC26A5 antisense RNA 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATPase activator activity TAS
    Traceable Author Statement
    more info
     
    enables Hsp70 protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables Hsp70 protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables RNA binding HDA PubMed 
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ribosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin-modified histone reader activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nuclear membrane IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    dnaJ homolog subfamily C member 2
    Names
    DnaJ (Hsp40) homolog, subfamily C, member 2
    M-phase phosphoprotein 11
    zuotin-related factor 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001129887.3NP_001123359.1  dnaJ homolog subfamily C member 2 isoform 2

      See identical proteins and their annotated locations for NP_001123359.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks two alternate in-frame exons, compared to variant 1, resulting in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AC004668, AI140595, X98260
      Consensus CDS
      CCDS47679.1
      UniProtKB/Swiss-Prot
      Q99543
      Related
      ENSP00000249270.7, ENST00000249270.11
      Conserved Domains (4) summary
      smart00717
      Location:498549
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      COG5269
      Location:75361
      ZUO1; Ribosome-associated chaperone zuotin [Translation, ribosomal structure and biogenesis / Posttranslational modification, protein turnover, chaperones]
      cd00167
      Location:500547
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam00226
      Location:88158
      DnaJ; DnaJ domain
    2. NM_001362667.2NP_001349596.1  dnaJ homolog subfamily C member 2 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in its 5' UTR, resulting in the use of a downstream start codon relative to variant 1. The encoded protein (isoform 3) has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AI140595, BC000859, BC056682, BX279826, DA691752
      Conserved Domains (3) summary
      COG5269
      Location:1294
      ZUO1; Ribosome-associated chaperone zuotin [Translation, ribosomal structure and biogenesis / Posttranslational modification, protein turnover, chaperones]
      cd00167
      Location:479526
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam16717
      Location:270346
      RAC_head; Ribosome-associated complex head domain
    3. NM_001362668.2NP_001349597.1  dnaJ homolog subfamily C member 2 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) contains an alternate exon in its 5' UTR, resulting in the use of a downstream start codon relative to variant 1. The encoded protein (isoform 3) has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AI140595, BC000859, BC056682, BX279826, DA691752
      Conserved Domains (3) summary
      cd00167
      Location:407454
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam16717
      Location:198274
      RAC_head; Ribosome-associated complex head domain
      cl28246
      Location:1222
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    4. NM_014377.3NP_055192.1  dnaJ homolog subfamily C member 2 isoform 1

      See identical proteins and their annotated locations for NP_055192.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AI140595, AI621015, BC000859, BC012376, DA272314, DA691752, X98260
      Consensus CDS
      CCDS43628.1
      UniProtKB/Swiss-Prot
      A4VCI0, Q99543, Q9BVX1
      Related
      ENSP00000368565.3, ENST00000379263.8
      Conserved Domains (5) summary
      smart00717
      Location:551602
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      COG5269
      Location:75368
      ZUO1; Ribosome-associated chaperone zuotin [Translation, ribosomal structure and biogenesis / Posttranslational modification, protein turnover, chaperones]
      cd00167
      Location:553600
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam00226
      Location:88158
      DnaJ; DnaJ domain
      pfam16717
      Location:349420
      RAC_head; Ribosome-associated complex head domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      103312289..103344767 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011516030.3XP_011514332.1  dnaJ homolog subfamily C member 2 isoform X1

      Conserved Domains (3) summary
      COG5269
      Location:2165
      ZUO1; Ribosome-associated chaperone zuotin [Translation, ribosomal structure and biogenesis / Posttranslational modification, protein turnover, chaperones]
      cd00167
      Location:350397
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam16717
      Location:141217
      RAC_head; Ribosome-associated complex head domain
    2. XM_047420191.1XP_047276147.1  dnaJ homolog subfamily C member 2 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      104626740..104659211 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054357878.1XP_054213853.1  dnaJ homolog subfamily C member 2 isoform X1

    2. XM_054357877.1XP_054213852.1  dnaJ homolog subfamily C member 2 isoform X1