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    Bcar1 breast cancer anti-estrogen resistance 1 [ Mus musculus (house mouse) ]

    Gene ID: 12927, updated on 9-Dec-2024

    Summary

    Official Symbol
    Bcar1provided by MGI
    Official Full Name
    breast cancer anti-estrogen resistance 1provided by MGI
    Primary source
    MGI:MGI:108091
    See related
    Ensembl:ENSMUSG00000031955 AllianceGenome:MGI:108091
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cas; Crkas
    Summary
    Predicted to enable protein domain specific binding activity and protein kinase binding activity. Involved in G protein-coupled receptor signaling pathway and platelet-derived growth factor receptor signaling pathway. Acts upstream of or within cell migration. Located in several cellular components, including actin cytoskeleton; focal adhesion; and lamellipodium. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and hemolymphoid system gland. Human ortholog(s) of this gene implicated in breast ductal carcinoma. Orthologous to human BCAR1 (BCAR1 scaffold protein, Cas family member). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 90.6), small intestine adult (RPKM 67.5) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Bcar1 in Genome Data Viewer
    Location:
    8 E1; 8 57.98 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (112437106..112470481, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (111710474..111743849, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9323 Neighboring gene STARR-positive B cell enhancer ABC_E885 Neighboring gene STARR-positive B cell enhancer ABC_E5042 Neighboring gene STARR-seq mESC enhancer starr_22707 Neighboring gene STARR-seq mESC enhancer starr_22708 Neighboring gene zinc finger protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E10523 Neighboring gene microRNA 7076 Neighboring gene chymotrypsinogen B1 Neighboring gene VISTA enhancer mm1686 Neighboring gene predicted gene, 51589 Neighboring gene STARR-seq mESC enhancer starr_22714 Neighboring gene STARR-seq mESC enhancer starr_22715 Neighboring gene predicted gene, 39252 Neighboring gene craniofacial development protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E6685 Neighboring gene STARR-positive B cell enhancer ABC_E6686

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (7)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in B cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in B cell receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in actin filament organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in actin filament organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in antigen receptor-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in antigen receptor-mediated signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular response to endothelin ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to hepatocyte growth factor stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to hepatocyte growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to nitric oxide ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endothelin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endothelin receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in epidermal growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in epidermal growth factor receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in hepatocyte growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in hepatocyte growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in insulin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in insulin receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in integrin-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in integrin-mediated signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of substrate adhesion-dependent cell spreading ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neurotrophin TRK receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neurotrophin TRK receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in platelet-derived growth factor receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of endothelial cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in vascular endothelial growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in vascular endothelial growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    is_active_in focal adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in focal adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in focal adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in lamellipodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    colocalizes_with plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in ruffle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in ruffle ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    breast cancer anti-estrogen resistance protein 1
    Names
    CRK-associated substrate
    p130 Cas
    p130cas
    v-crk-associated tyrosine kinase substrate

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001198839.1NP_001185768.1  breast cancer anti-estrogen resistance protein 1 isoform A

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript and encodes isoform A. Isoforms A and B are the same length but differ by 4 N-terminal amino acids.
      Source sequence(s)
      AK167352, BC057578
      Consensus CDS
      CCDS85616.1
      UniProtKB/TrEMBL
      Q3TJB5, Q3TXP6
      Related
      ENSMUSP00000148364.2, ENSMUST00000212349.2
      Conserved Domains (3) summary
      cd11552
      Location:458614
      Serine_rich_BCAR1; Serine rich Four helix bundle domain of CAS (Crk-Associated Substrate) scaffolding protein, Breast Cancer Anti-estrogen Resistance 1; a protein interaction module
      cd12001
      Location:471
      SH3_BCAR1; Src homology 3 domain of the CAS (Crk-Associated Substrate) scaffolding protein family member, Breast Cancer Anti-estrogen Resistance 1
      pfam12026
      Location:659868
      DUF3513; Domain of unknown function (DUF3513)
    2. NM_009954.3NP_034084.2  breast cancer anti-estrogen resistance protein 1 isoform B

      See identical proteins and their annotated locations for NP_034084.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, compared to variant 1, and encodes isoform B. Isoforms A and B are the same length but differ by 4 N-terminal amino acids.
      Source sequence(s)
      BC057578, BY733553
      Consensus CDS
      CCDS52675.1
      UniProtKB/Swiss-Prot
      Q60869, Q61140, Q6PFF9
      UniProtKB/TrEMBL
      Q3TIT7
      Related
      ENSMUSP00000129584.3, ENSMUST00000166232.4
      Conserved Domains (3) summary
      cd11552
      Location:458614
      Serine_rich_BCAR1; Serine rich Four helix bundle domain of CAS (Crk-Associated Substrate) scaffolding protein, Breast Cancer Anti-estrogen Resistance 1; a protein interaction module
      cd12001
      Location:571
      SH3_BCAR1; Src homology 3 domain of the CAS (Crk-Associated Substrate) scaffolding protein family member, Breast Cancer Anti-estrogen Resistance 1
      pfam12026
      Location:659868
      DUF3513; Domain of unknown function (DUF3513)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      112437106..112470481 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)