CSRP2 cysteine and glycine rich protein 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: CSRP2provided by HGNC
Official Full Name: cysteine and glycine rich protein 2provided by HGNC
Primary source: HGNC:HGNC:2470
See related: Ensembl:ENSG00000175183 MIM:601871; AllianceGenome:HGNC:2470
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CRP2; LMO5; SmLIM
Summary: CSRP2 is a member of the CSRP family of genes, encoding a group of LIM domain proteins, which may be involved in regulatory processes important for development and cellular differentiation. CRP2 contains two copies of the cysteine-rich amino acid sequence motif (LIM) with putative zinc-binding activity, and may be involved in regulating ordered cell growth. Other genes in the family include CSRP1 and CSRP3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Expression: Ubiquitous expression in esophagus (RPKM 37.2), placenta (RPKM 35.3) and 23 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 12q21.2

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	12	NC_000012.12 (76858709..76879019, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	12	NC_060936.1 (76836580..76856889, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	12	NC_000012.11 (77252489..77272799, complement)

Chromosome 12 - NC_000012.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Significance of the p38MAPK-CRP2 axis in myofibroblastic phenotypic transition.
Title: Significance of the p38MAPK-CRP2 axis in myofibroblastic phenotypic transition.
Role of CRP2-MRTF interaction in functions of myofibroblasts.
Title: Role of CRP2-MRTF interaction in functions of myofibroblasts.
CSRP2 suppresses colorectal cancer progression via p130Cas/Rac1 axis-meditated ERK, PAK, and HIPPO signaling pathways.
Title: CSRP2 suppresses colorectal cancer progression via p130Cas/Rac1 axis-meditated ERK, PAK, and HIPPO signaling pathways.
Study showed that CSRP2, an invadopodial actin bundling protein, is upregulated by hypoxia in various breast cancer cell lines, as well as in pre-clinical and clinical breast tumor specimens and functionally characterized two hypoxia responsive elements within the proximal promoter of CSRP2 gene which are targeted by hypoxia-inducible factor-1 (HIF-1) and required for promoter transactivation in response to hypoxia.
Title: Hypoxia promotes breast cancer cell invasion through HIF-1α-mediated up-regulation of the invadopodial actin bundling protein CSRP2.
CSRP2 promoted cell proliferation, cell-cycle progression, in vitro colony formation and cell migration ability. Abnormal CSRP2 expression was associated with resistance to chemotherapy; sensitivity was restored by down-regulating CSRP2 expression.
Title: Cysteine and glycine-rich protein 2 (CSRP2) transcript levels correlate with leukemia relapse and leukemia-free survival in adults with B-cell acute lymphoblastic leukemia and normal cytogenetics.
the effect of proteasome inhibition on IL-10 activation of the IL-10E1 pathway [Il-10E1]
Title: Interleukin-10 activation of the interleukin-10E1 pathway and tissue inhibitor of metalloproteinase-1 expression is enhanced by proteasome inhibitors in primary prostate tumor lines.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D12S2101 (e-PCR)
- UniSTS:32811

D12S1684 (e-PCR), detects polymorphism
- UniSTS:48968

D3S4161 (e-PCR)
- UniSTS:910

RH70679 (e-PCR)
- UniSTS:91639

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables actinin binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural constituent of muscle	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell differentiation	NAS Non-traceable Author Statement more info	PubMed
involved_in muscle tissue development	IBA Inferred from Biological aspect of Ancestor more info
involved_in sarcomere organization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in Z disc	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in focal adhesion	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: cysteine and glycine-rich protein 2

Names: LIM domain only 5, smooth muscle; LIM domain only protein 5; LMO-5; cysteine-rich protein 2; epididymis secretory sperm binding protein; smooth muscle cell LIM protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001300965.2 → NP_001287894.1 cysteine and glycine-rich protein 2 isoform b

See identical proteins and their annotated locations for NP_001287894.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) encodes isoform b. Variants 1-5 all encode the same isoform (b).

Source sequence(s)

AC124784, BC000992, BX461295, CN408330

Consensus CDS

CCDS9015.1

UniProtKB/Swiss-Prot

Q16527, Q93030

UniProtKB/TrEMBL

A0A024RBB5, F8VQR7

Related

ENSP00000450056.1, ENST00000546966.5

Conserved Domains (2) summary

cd09480
Location:9 → 63

LIM1_CRP2; The first LIM domain of Cysteine Rich Protein 2 (CRP2)

cd09840
Location:119 → 172

LIM2_CRP2; The second LIM domain of Cysteine Rich Protein 2 (CRP2)
NM_001321.3 → NP_001312.1 cysteine and glycine-rich protein 2 isoform b

See identical proteins and their annotated locations for NP_001312.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes isoform b. Variants 1-5 all encode the same isoform (b).

Source sequence(s)

AC124784, BC000992, BX461295

Consensus CDS

CCDS9015.1

UniProtKB/Swiss-Prot

Q16527, Q93030

UniProtKB/TrEMBL

A0A024RBB5, F8VQR7

Related

ENSP00000310901.5, ENST00000311083.10

Conserved Domains (2) summary

cd09480
Location:9 → 63

LIM1_CRP2; The first LIM domain of Cysteine Rich Protein 2 (CRP2)

cd09840
Location:119 → 172

LIM2_CRP2; The second LIM domain of Cysteine Rich Protein 2 (CRP2)
NM_001413535.1 → NP_001400464.1 cysteine and glycine-rich protein 2 isoform b

Status: REVIEWED

Source sequence(s)

AC124784

UniProtKB/Swiss-Prot

Q16527, Q93030

UniProtKB/TrEMBL

A0A024RBB5
NM_001413537.1 → NP_001400466.1 cysteine and glycine-rich protein 2 isoform b

Status: REVIEWED

Source sequence(s)

AC124784

UniProtKB/Swiss-Prot

Q16527, Q93030

UniProtKB/TrEMBL

A0A024RBB5
NM_001413538.1 → NP_001400467.1 cysteine and glycine-rich protein 2 isoform b

Status: REVIEWED

Source sequence(s)

AC124784

UniProtKB/Swiss-Prot

Q16527, Q93030

UniProtKB/TrEMBL

A0A024RBB5
NM_001413539.1 → NP_001400468.1 cysteine and glycine-rich protein 2 isoform a

Status: REVIEWED

Source sequence(s)

AC124784

UniProtKB/TrEMBL

F8VW96

Related

ENSP00000449824.1, ENST00000552330.5
NM_001413540.1 → NP_001400469.1 cysteine and glycine-rich protein 2 isoform c

Status: REVIEWED

Source sequence(s)

AC124784
NM_001413541.1 → NP_001400470.1 cysteine and glycine-rich protein 2 isoform d

Status: REVIEWED

Source sequence(s)

AC124784
NM_001413542.1 → NP_001400471.1 cysteine and glycine-rich protein 2 isoform e

Status: REVIEWED

Source sequence(s)

AC124784