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    DHRS7B dehydrogenase/reductase 7B [ Homo sapiens (human) ]

    Gene ID: 25979, updated on 27-Nov-2024

    Summary

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    Official Symbol
    DHRS7Bprovided by HGNC
    Official Full Name
    dehydrogenase/reductase 7Bprovided by HGNC
    Primary source
    HGNC:HGNC:24547
    See related
    Ensembl:ENSG00000109016 MIM:616160; AllianceGenome:HGNC:24547
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CGI-93; SDR32C1
    Summary
    Predicted to enable acylglycerone-phosphate reductase (NADP+) activity. Predicted to be involved in ether lipid biosynthetic process. Predicted to act upstream of or within several processes, including brown fat cell differentiation; phosphatidylcholine biosynthetic process; and regulation of cold-induced thermogenesis. Located in membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis (RPKM 7.1), thyroid (RPKM 6.1) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See DHRS7B in Genome Data Viewer
    Location:
    17p11.2
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (21126964..21191420)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (21068745..21140297)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (21030277..21094733)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124900389 Neighboring gene ubiquitin specific peptidase 22 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:20937215-20937716 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8311 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:20946145-20947094 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:20947095-20948042 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:20954728-20955314 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11877 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:20970211-20970711 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:20978550-20979050 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr17:20987896-20989095 Neighboring gene long intergenic non-protein coding RNA 1563 Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr17:21002173-21002789 and GRCh37_chr17:21002790-21003407 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr17:21011664-21012527 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11879 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:21102215-21103012 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:21108419-21109051 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11880 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8313 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8314 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11881 Neighboring gene transmembrane protein 11 Neighboring gene TMEM11 divergent transcript

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Genome-wide association study identifies loci affecting blood copper, selenium and zinc. Evans DM, et al. Hum Mol Genet, 2013 Oct 1. PMID 23720494, Free PMC Article
    2. WWP2-WWP1 ubiquitin ligase complex coordinated by PPM1G maintains the balance between cellular p73 and ΔNp73 levels. Chaudhary N, et al. Mol Cell Biol, 2014 Oct 1. PMID 25071155, Free PMC Article
    3. VE-822 upregulates the deubiquitinase OTUD1 to stabilize FHL1 to inhibit the progression of lung adenocarcinoma. Zhang Q, et al. Cell Oncol (Dordr), 2023 Aug. PMID 36929488
    4. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. Lai CH, et al. Genome Res, 2000 May. PMID 10810093, Free PMC Article
    5. High Throughput Chemical Screening Reveals Multiple Regulatory Proteins on FOXA1 in Breast Cancer Cell Lines. Wang S, et al. Int J Mol Sci, 2018 Dec 19. PMID 30572598, Free PMC Article

    See all (65) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies loci affecting blood copper, selenium and zinc.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC8916, FLJ42061, FLJ99908, DKFZp566O084

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acylglycerone-phosphate reductase (NADP+) activity TAS
    Traceable Author Statement
    more info
    		  
    enables transcription corepressor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in adipose tissue development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in brown fat cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ether lipid biosynthetic process TAS
    Traceable Author Statement
    more info
    		  
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neutrophil differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphatidylcholine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cold-induced thermogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane HDA PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in peroxisomal membrane TAS
    Traceable Author Statement
    more info
    		  
    part_of transcription regulator complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    dehydrogenase/reductase SDR family member 7B
    Names
    dehydrogenase/reductase (SDR family) member 7B
    short-chain dehydrogenase/reductase family 32C member 1
    NP_001317088.1
    NP_001380586.1
    NP_001380587.1
    NP_001380588.1
    NP_001380589.1
    NP_056325.2
    XP_011522088.1
    XP_024306453.1
    XP_047291678.1
    XP_047291679.1
    XP_047291680.1
    XP_047291681.1
    XP_054171637.1
    XP_054171638.1
    XP_054171639.1
    XP_054171640.1
    XP_054171641.1
    XP_054171642.1
    XP_054171643.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001330159.3 → NP_001317088.1  dehydrogenase/reductase SDR family member 7B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC087393
      Consensus CDS
      CCDS82092.1
      UniProtKB/TrEMBL
      A0A0C4DGQ8
      Related
      ENSP00000468585.1, ENST00000579303.5

    2. NM_001393657.1 → NP_001380586.1  dehydrogenase/reductase SDR family member 7B isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC087393
      Conserved Domains (1) summary
      cd05332
      Location:50 → 309
      11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs

    3. NM_001393658.1 → NP_001380587.1  dehydrogenase/reductase SDR family member 7B isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC087393
      Conserved Domains (1) summary
      cd05332
      Location:50 → 307
      11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs

    4. NM_001393659.1 → NP_001380588.1  dehydrogenase/reductase SDR family member 7B isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC087393
      Conserved Domains (1) summary
      cl21454
      Location:50 → 260
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    5. NM_001393660.1 → NP_001380589.1  dehydrogenase/reductase SDR family member 7B isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC087393
      Conserved Domains (1) summary
      cd05332
      Location:50 → 260
      11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs

    6. NM_015510.5 → NP_056325.2  dehydrogenase/reductase SDR family member 7B isoform 1

      See identical proteins and their annotated locations for NP_056325.2

      Status: VALIDATED

      Source sequence(s)
      AC087393
      Consensus CDS
      CCDS11215.1
      UniProtKB/Swiss-Prot
      B5MEF4, Q6IAN0, Q6UX59, Q9BTF9, Q9UFM6, Q9Y3A1
      Related
      ENSP00000378887.3, ENST00000395511.8
      Conserved Domains (1) summary
      cd05332
      Location:50 → 311
      11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      21126964..21191420
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047435722.1 → XP_047291678.1  dehydrogenase/reductase SDR family member 7B isoform X1

    2. XM_011523786.3 → XP_011522088.1  dehydrogenase/reductase SDR family member 7B isoform X4

      Conserved Domains (2) summary
      cd05332
      Location:97 → 304
      11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs
      pfam00106
      Location:101 → 294
      adh_short; short chain dehydrogenase

    3. XM_024450685.2 → XP_024306453.1  dehydrogenase/reductase SDR family member 7B isoform X6

      Conserved Domains (1) summary
      cd05332
      Location:50 → 257
      11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs

    4. XM_047435724.1 → XP_047291680.1  dehydrogenase/reductase SDR family member 7B isoform X3

    5. XM_047435723.1 → XP_047291679.1  dehydrogenase/reductase SDR family member 7B isoform X2

    6. XM_047435725.1 → XP_047291681.1  dehydrogenase/reductase SDR family member 7B isoform X5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      21068745..21140297
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054315667.1 → XP_054171642.1  dehydrogenase/reductase SDR family member 7B isoform X7

      UniProtKB/Swiss-Prot
      B5MEF4, Q6IAN0, Q6UX59, Q9BTF9, Q9UFM6, Q9Y3A1

    2. XM_054315662.1 → XP_054171637.1  dehydrogenase/reductase SDR family member 7B isoform X1

    3. XM_054315665.1 → XP_054171640.1  dehydrogenase/reductase SDR family member 7B isoform X4

    4. XM_054315668.1 → XP_054171643.1  dehydrogenase/reductase SDR family member 7B isoform X6

    5. XM_054315664.1 → XP_054171639.1  dehydrogenase/reductase SDR family member 7B isoform X3

    6. XM_054315663.1 → XP_054171638.1  dehydrogenase/reductase SDR family member 7B isoform X2

    7. XM_054315666.1 → XP_054171641.1  dehydrogenase/reductase SDR family member 7B isoform X5

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001393656.1: Suppressed sequence

      Description
      NM_001393656.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6IAN0.2 GenPept UniProtKB/Swiss-Prot:Q6IAN0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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