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    MDR1 GTPase-activating protein MDR1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852992, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MDR1
    Official Full Name
    GTPase-activating protein MDR1
    Primary source
    SGD:S000003332
    Locus tag
    YGR100W
    See related
    AllianceGenome:SGD:S000003332; FungiDB:YGR100W; VEuPathDB:YGR100W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    GYP2; MIC1
    Summary
    Enables GTPase activator activity. Involved in activation of GTPase activity. Located in cytoplasm and mating projection tip. Human ortholog(s) of this gene implicated in nephrotic syndrome type 20. Orthologous to several human genes including TBC1D8 (TBC1 domain family member 8); TBC1D8B (TBC1 domain family member 8B); and TBC1D9 (TBC1 domain family member 9). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MDR1 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (690245..693097)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene separase Neighboring gene Tel2p Neighboring gene rhomboid protease PCP1 Neighboring gene glutamyl-tRNA(Gln) amidotransferase subunit F

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Opposite roles of the F-box protein Rcy1p and the GTPase-activating protein Gyp2p during recycling of internalized proteins in yeast. Lafourcade C, et al. Genetics, 2003 Jun. PMID 12807768, Free PMC Article
    2. The Msb3/Gyp3 GAP controls the activity of the Rab GTPases Vps21 and Ypt7 at endosomes and vacuoles. Lachmann J, et al. Mol Biol Cell, 2012 Jul. PMID 22593206, Free PMC Article
    3. A positive feedback loop involving the Spa2 SHD domain contributes to focal polarization. Lawson MJ, et al. PLoS One, 2022. PMID 35134079, Free PMC Article
    4. Involvement of Golgi-associated retrograde protein complex in the recycling of the putative Dnf aminophospholipid flippases in yeast. Takagi K, et al. Biochem Biophys Res Commun, 2012 Jan 6. PMID 22177957
    5. Identification of novel, evolutionarily conserved Cdc42p-interacting proteins and of redundant pathways linking Cdc24p and Cdc42p to actin polarization in yeast. Bi E, et al. Mol Biol Cell, 2000 Feb. PMID 10679030, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in activation of GTPase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mating projection tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in site of polarized growth IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    GTPase-activating protein MDR1
    NP_011614.1
    • Cytoplasmic GTPase-activating protein; activates Ypt/Rab transport GTPases Ypt6p, Ypt31p and Sec4p; involved in recycling of internalized proteins and regulation of Golgi secretory function

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      690245..693097
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181229.1 → NP_011614.1  TPA: GTPase-activating protein MDR1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011614.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUN2, P53258
      UniProtKB/TrEMBL
      A6ZV82, B3LIC6, C7GWW3, C8Z8Z3
      Conserved Domains (1) summary
      COG5210
      Location:23 → 531
      COG5210; GTPase-activating protein [General function prediction only]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53258.1

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