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    COA4 Coa4p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850915, updated on 9-Dec-2024

    Summary

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    Official Symbol
    COA4
    Official Full Name
    Coa4p
    Primary source
    SGD:S000004208
    Locus tag
    YLR218C
    See related
    AllianceGenome:SGD:S000004208; FungiDB:YLR218C; VEuPathDB:YLR218C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CMC3
    Summary
    Involved in mitochondrial cytochrome c oxidase assembly. Located in mitochondrial intermembrane space. Orthologous to human COA4 (cytochrome c oxidase assembly factor 4 homolog). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See COA4 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (573466..573918, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene cell proliferation protein CDC123 Neighboring gene peptidylprolyl isomerase CPR6 Neighboring gene Msc3p Neighboring gene Ccc1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A yeast suppressor screen links Coa4 to the mitochondrial copper delivery pathway for cytochrome c oxidase. Swaminathan AB, et al. Genetics, 2022 Jul 30. PMID 35666203, Free PMC Article
    2. Inaccurately assembled cytochrome c oxidase can lead to oxidative stress-induced growth arrest. Bode M, et al. Antioxid Redox Signal, 2013 May 1. PMID 23198688, Free PMC Article
    3. Analysis of Leigh syndrome mutations in the yeast SURF1 homolog reveals a new member of the cytochrome oxidase assembly factor family. Bestwick M, et al. Mol Cell Biol, 2010 Sep. PMID 20624914, Free PMC Article
    4. Systematic screen for human disease genes in yeast. Steinmetz LM, et al. Nat Genet, 2002 Aug. PMID 12134146
    5. Systematic analysis of the twin cx(9)c protein family. Longen S, et al. J Mol Biol, 2009 Oct 23. PMID 19703468

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial cytochrome c oxidase assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial cytochrome c oxidase assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mitochondrial cytochrome c oxidase assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial respiratory chain complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrial intermembrane space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial intermembrane space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial intermembrane space IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    Coa4p
    NP_013319.1
    • Twin Cx(9)C protein involved in cytochrome c oxidase organization; organization includes assembly or stability; localizes to the mitochondrial intermembrane space via the Mia40p-Erv1p system; interacts genetically with CYC1 and with cytochrome c oxidase assembly factors; mutation can be complemented by human COA4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      573466..573918 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182105.1 → NP_013319.1  TPA: Coa4p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013319.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A7A1A5, B3RHA6, C7GIU6, C8ZDI2, N1NZU5
    Nucleotide Protein
    Heading Accession and Version

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