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    CSF1 Csf1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850776, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CSF1
    Official Full Name
    Csf1p
    Primary source
    SGD:S000004077
    Locus tag
    YLR087C
    See related
    AllianceGenome:SGD:S000004077; FungiDB:YLR087C; VEuPathDB:YLR087C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in fermentation and protein maturation. Acts upstream of or within phospholipid homeostasis. Located in mitochondrion. Human ortholog(s) of this gene implicated in Alkuraya-Kucinskas syndrome. Orthologous to human BLTP1 (bridge-like lipid transfer protein family member 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See CSF1 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (306855..315731, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Arp6p Neighboring gene condensin subunit SMC4 Neighboring gene GPI-anchor transamidase subunit GAA1 Neighboring gene alanine transaminase ALT1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Rewiring phospholipid biosynthesis reveals resilience to membrane perturbations and uncovers regulators of lipid homeostasis. John Peter AT, et al. EMBO J, 2022 Apr 4. PMID 35188676, Free PMC Article
    2. Cloning and characterization of the CSF1 gene of Saccharomyces cerevisiae, which is required for nutrient uptake at low temperature. Tokai M, et al. J Bacteriol, 2000 May. PMID 10781556, Free PMC Article
    3. Vps13-like proteins provide phosphatidylethanolamine for GPI anchor synthesis in the ER. Toulmay A, et al. J Cell Biol, 2022 Mar 7. PMID 35015055, Free PMC Article
    4. A complex genetic interaction implicates that phospholipid asymmetry and phosphate homeostasis regulate Golgi functions. Miyasaka M, et al. PLoS One, 2020. PMID 32730286, Free PMC Article
    5. Analysis of low temperature-induced genes (LTIG) in wine yeast during alcoholic fermentation. Chiva R, et al. FEMS Yeast Res, 2012 Nov. PMID 22835029

    See all (69) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in fermentation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fermentation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phospholipid homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phospholipid homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phospholipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Csf1p
    NP_013188.1
    • Protein with structural similarity to lipid transport protein Vps13p; localizes to multiple membrane contact sites between organelles; role in phospholipid homeostasis and lipidomic adaptation to cold; required for fermentation at low temperature; plays a role in phosphatidylethanolamine metabolism and secretory protein maturation; non-tagged protein is detected in highly purified mitochondria in HTP studies

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      306855..315731 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181974.1 → NP_013188.1  TPA: Csf1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013188.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VY87, Q12150
      UniProtKB/TrEMBL
      A7A0Z1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12150.1

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