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    SYN8 syntaxin [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851219, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SYN8
    Official Full Name
    syntaxin
    Primary source
    SGD:S000000012
    Locus tag
    YAL014C
    See related
    AllianceGenome:SGD:S000000012; FungiDB:YAL014C; VEuPathDB:YAL014C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    SLT2; UIP2
    Summary
    Enables SNAP receptor activity. Involved in Golgi to vacuole transport. Located in endosome. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SYN8 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_001133.9 (128252..129019, complement)

    Chromosome I - NC_001133.9Genomic Context describing neighboring genes Neighboring gene protein phosphatase 2A structural subunit TPD3 Neighboring gene bifunctional N-glycosylase/AP lyase NTG1 Neighboring gene Rpd3L histone deacetylase complex subunit DEP1 Neighboring gene cystathionine gamma-lyase CYS3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001133.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ENTH domain proteins are cargo adaptors for multiple SNARE proteins at the TGN endosome. Chidambaram S, et al. J Cell Sci, 2008 Feb 1. PMID 18198191
    2. Dissecting Ent3p: the ENTH domain binds different SNAREs via distinct amino acid residues while the C-terminus is sufficient for retrograde transport from endosomes. Zimmermann J, et al. Biochem J, 2010 Oct 1. PMID 20658963
    3. A new yeast endosomal SNARE related to mammalian syntaxin 8. Lewis MJ, et al. Traffic, 2002 Dec. PMID 12453154
    4. Distinct contributions of vacuolar Qabc- and R-SNARE proteins to membrane fusion specificity. Izawa R, et al. J Biol Chem, 2012 Jan 27. PMID 22174414, Free PMC Article
    5. The canonical DHHC motif is not absolutely required for the activity of the yeast S-acyltransferases Swf1 and Pfa4. González Montoro A, et al. J Biol Chem, 2015 Sep 11. PMID 26224664, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables SNAP receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SNAP receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi to vacuole transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in Golgi to vacuole transport IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in membrane fusion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle docking IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of SNARE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    syntaxin
    NP_009388.2
    • Endosomal SNARE related to mammalian syntaxin 8

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001133.9 Reference assembly

      Range
      128252..129019 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178159.1 → NP_009388.2  TPA: syntaxin [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009388.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VPK4, P31377
      UniProtKB/TrEMBL
      B5VDK9, C7GPM1, C8Z3L6, N1PAZ2
      Conserved Domains (1) summary
      cd15859
      Location:167 → 236
      SNARE_SYN8; SNARE motif of SYN8
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P31377.2

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