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    TOH1 Toh1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853268, updated on 9-Dec-2024

    Summary

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    Official Symbol
    TOH1
    Official Full Name
    Toh1p
    Primary source
    SGD:S000003707
    Locus tag
    YJL171C
    See related
    AllianceGenome:SGD:S000003707; FungiDB:YJL171C; VEuPathDB:YJL171C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable hydrolase activity, acting on glycosyl bonds. Predicted to be involved in cell wall organization. Located in fungal-type cell wall. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See TOH1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (99704..100894, complement)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Rfa3p Neighboring gene Gly-Xaa carboxypeptidase Neighboring gene Asg7p Neighboring gene histone methyltransferase SET2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Amyloid properties of the yeast cell wall protein Toh1 and its interaction with prion proteins Rnq1 and Sup35. Sergeeva AV, et al. Prion, 2019 Jan. PMID 30558459, Free PMC Article
    2. Screening for glycosylphosphatidylinositol (GPI)-dependent cell wall proteins in Saccharomyces cerevisiae. Hamada K, et al. Mol Gen Genet, 1998 Apr. PMID 9613572
    3. Beneficial Mutations from Evolution Experiments Increase Rates of Growth and Fermentation. Sezmis AL, et al. J Mol Evol, 2018 Feb. PMID 29349600
    4. Genome-wide analysis of the response to cell wall mutations in the yeast Saccharomyces cerevisiae. Lagorce A, et al. J Biol Chem, 2003 May 30. PMID 12644457
    5. The global transcriptional response to transient cell wall damage in Saccharomyces cerevisiae and its regulation by the cell integrity signaling pathway. García R, et al. J Biol Chem, 2004 Apr 9. PMID 14739279

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables hydrolase activity, acting on glycosyl bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cell wall organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    is_active_in fungal-type cell wall IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in fungal-type cell wall IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in plasma membrane HDA PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Toh1p
    NP_012364.2
    • GPI-anchored cell wall hypothetical protein; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      99704..100894 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181604.2 → NP_012364.2  TPA: Toh1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012364.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VW17, P46992
      UniProtKB/TrEMBL
      A6ZQG2, B3LPV3, C7GRZ8, C8ZB48, G2WGK3, N1P1E2
      Conserved Domains (2) summary
      pfam10287
      Location:107 → 336
      DUF2401; Putative TOS1-like glycosyl hydrolase (DUF2401)
      pfam10290
      Location:27 → 90
      DUF2403; Glycine-rich protein domain (DUF2403)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P46992.2

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