RFA3 Rfa3p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: RFA3
Official Full Name: Rfa3p
Primary source: SGD:S000003709
Locus tag: YJL173C
See related: AllianceGenome:SGD:S000003709; FungiDB:YJL173C; VEuPathDB:YJL173C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: RPA14; RPA3
Summary: Enables double-stranded DNA binding activity and sequence-specific DNA binding activity. Involved in DNA metabolic process; establishment of protein localization; and protein ubiquitination. Located in chromosome, telomeric region and condensed nuclear chromosome. Part of DNA replication factor A complex. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See RFA3 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 1

Sequence:: Chromosome: X; NC_001142.9 (96161..96529, complement)

Chromosome X - NC_001142.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

forms part of Replication Protein A (RPA) heterotrimer; dynamic DNA-binding domains promote the cooperative assembly of multiple RPAs on long ssDNA
Title: A structural and dynamic model for the assembly of Replication Protein A on single-stranded DNA.
Results show that DNA damage response at eroded telomeres is characterized by the recruitment of Cdc13, replication protein A, DNA damage checkpoint proteins and the DNA repair protein Rad52 into a single focus.
Title: The DNA damage response at eroded telomeres and tethering to the nuclear pore complex.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA recombination	IEA Inferred from Electronic Annotation more info
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in DNA repair	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in DNA replication	IEA Inferred from Electronic Annotation more info
involved_in DNA replication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in DNA topological change	IDA Inferred from Direct Assay more info	PubMed
involved_in DNA unwinding involved in DNA replication	IDA Inferred from Direct Assay more info	PubMed
involved_in double-strand break repair via homologous recombination	IGI Inferred from Genetic Interaction more info	PubMed
involved_in establishment of protein localization	IPI Inferred from Physical Interaction more info	PubMed
involved_in heteroduplex formation	IDA Inferred from Direct Assay more info	PubMed
involved_in mitotic recombination	IPI Inferred from Physical Interaction more info	PubMed
involved_in nucleotide-excision repair	IDA Inferred from Direct Assay more info	PubMed
involved_in protein ubiquitination	IPI Inferred from Physical Interaction more info	PubMed
involved_in reciprocal meiotic recombination	IPI Inferred from Physical Interaction more info	PubMed
involved_in telomere maintenance via recombination	IPI Inferred from Physical Interaction more info	PubMed
involved_in telomere maintenance via telomerase	IPI Inferred from Physical Interaction more info	PubMed
involved_in telomere maintenance via telomere lengthening	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of DNA replication factor A complex	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome, telomeric region	IMP Inferred from Mutant Phenotype more info	PubMed
located_in condensed nuclear chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear lumen	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Rfa3p

NP_012362.1

Subunit of heterotrimeric Replication Protein A (RPA); RPA is a highly conserved single-stranded DNA binding protein complex involved in DNA replication, repair, recombination; RPA protects against inappropriate telomere recombination, and upon telomere uncapping, prevents cell proliferation by a checkpoint-independent pathway; with Sgs1p-Top2p-Rmi1p, stimulates DNA catenation/decatenation activity of Top3p; protein abundance increases in response to DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001142.9 Reference assembly

Range

96161..96529 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181606.1 → NP_012362.1 TPA: Rfa3p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012362.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VW15, P26755

UniProtKB/TrEMBL

A6ZQG0, G2WGK1

Conserved Domains (1) summary

pfam08661
Location:1 → 122

Rep_fac-A_3; Replication factor A protein 3