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    KRE29 Smc5-Smc6 complex subunit KRE29 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856760, updated on 9-Dec-2024

    Summary

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    Official Symbol
    KRE29
    Official Full Name
    Smc5-Smc6 complex subunit KRE29
    Primary source
    SGD:S000000840
    Locus tag
    YER038C
    See related
    AllianceGenome:SGD:S000000840; FungiDB:YER038C; VEuPathDB:YER038C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    NSE6
    Summary
    Enables ATPase inhibitor activity. Contributes to SUMO transferase activity. Involved in DNA repair. Located in cytoplasm and nucleus. Part of Smc5-Smc6 complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See KRE29 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (226858..228252, complement)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene ATP-binding cassette family ATPase ARB1 Neighboring gene bifunctional nucleotidase/lysophosphatidic acid phosphatase Neighboring gene Fmp49p Neighboring gene putative GDP-mannose transporter Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nse5/6 is a negative regulator of the ATPase activity of the Smc5/6 complex. Hallett ST, et al. Nucleic Acids Res, 2021 May 7. PMID 33849072, Free PMC Article
    2. Nse5/6 inhibits the Smc5/6 ATPase and modulates DNA substrate binding. Taschner M, et al. EMBO J, 2021 Aug 2. PMID 34191293, Free PMC Article
    3. Cryo-EM structure of DNA-bound Smc5/6 reveals DNA clamping enabled by multi-subunit conformational changes. Yu Y, et al. Proc Natl Acad Sci U S A, 2022 Jun 7. PMID 35648833, Free PMC Article
    4. Molecular basis for Nse5-6 mediated regulation of Smc5/6 functions. Li S, et al. Proc Natl Acad Sci U S A, 2023 Nov 7. PMID 37903273, Free PMC Article
    5. Cryo-EM structures of Smc5/6 in multiple states reveal its assembly and functional mechanisms. Li Q, et al. Nat Struct Mol Biol, 2024 Oct. PMID 38890552,

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Nse5/6 inhibits the Smc5/6 ATPase and modulates DNA substrate binding.
      Title: Nse5/6 inhibits the Smc5/6 ATPase and modulates DNA substrate binding.
    2. Nse5/6 is a negative regulator of the ATPase activity of the Smc5/6 complex.
      Title: Nse5/6 is a negative regulator of the ATPase activity of the Smc5/6 complex.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATPase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to SUMO transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Smc5-Smc6 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Smc5-Smc6 complex subunit KRE29
    NP_010955.3
    • Subunit of the SMC5-SMC6 complex; this complex is involved in removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      226858..228252 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178929.3 → NP_010955.3  TPA: Smc5-Smc6 complex subunit KRE29 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010955.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DLT7, P40026
      UniProtKB/TrEMBL
      A6ZQY7, C8Z740
      Conserved Domains (1) summary
      pfam08691
      Location:1 → 454
      Nse5; DNA repair proteins Nse5 and Nse6
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40026.1

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