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    RPL37B ribosomal 60S subunit protein L37B [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852111, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RPL37B
    Official Full Name
    ribosomal 60S subunit protein L37B
    Primary source
    SGD:S000002908
    Locus tag
    YDR500C
    See related
    AllianceGenome:SGD:S000002908; FungiDB:YDR500C; VEuPathDB:YDR500C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable RNA binding activity. Involved in cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Part of cytosolic large ribosomal subunit and preribosome, large subunit precursor. Orthologous to human RPL37 (ribosomal protein L37). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RPL37B in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    2
    Sequence:
    Chromosome: IV; NC_001136.10 (1450198..1450853, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Sec20p Neighboring gene Lcd1p Neighboring gene Plm2p Neighboring gene methionine adenosyltransferase SAM2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity. Managbanag JR, et al. PLoS One, 2008. PMID 19030232, Free PMC Article
    2. Overexpression of budding yeast protein phosphatase Ppz1 impairs translation. Calafí C, et al. Biochim Biophys Acta Mol Cell Res, 2020 Aug. PMID 32339526
    3. Yeast polypeptide exit tunnel ribosomal proteins L17, L35 and L37 are necessary to recruit late-assembling factors required for 27SB pre-rRNA processing. Gamalinda M, et al. Nucleic Acids Res, 2013 Feb 1. PMID 23268442, Free PMC Article
    4. Sir2 deletion prevents lifespan extension in 32 long-lived mutants. Delaney JR, et al. Aging Cell, 2011 Dec. PMID 21902802, Free PMC Article
    5. Direct mass spectrometric analysis of intact proteins of the yeast large ribosomal subunit using capillary LC/FTICR. Lee SW, et al. Proc Natl Acad Sci U S A, 2002 Apr 30. PMID 11983894, Free PMC Article

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables rRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of ribosome IC
    Inferred by Curator
    more info
    		 PubMed 
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cytoplasmic translation IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of cytosolic large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic large ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of preribosome, large subunit precursor IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribosomal subunit IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ribosomal 60S subunit protein L37B
    NP_010788.1
    • Ribosomal 60S subunit protein L37B; required for processing of 27SB pre-rRNA and formation of stable 66S assembly intermediates; protein abundance increases in response to DNA replication stress; homologous to mammalian ribosomal protein L37, no bacterial homolog; RPL37B has a paralog, RPL37A, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1450198..1450853 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180808.1 → NP_010788.1  TPA: ribosomal 60S subunit protein L37B [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010788.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTC2, P51402
      UniProtKB/TrEMBL
      A6ZZ89, B3LFG7, C8Z657, G2WBM8, N1PAL4
      Conserved Domains (1) summary
      PTZ00073
      Location:1 → 83
      PTZ00073; 60S ribosomal protein L37; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P51402.2

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