KTR4 putative mannosyltransferase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: KTR4
Official Full Name: putative mannosyltransferase
Primary source: SGD:S000000403
Locus tag: YBR199W
See related: AllianceGenome:SGD:S000000403; FungiDB:YBR199W; VEuPathDB:YBR199W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables mannosyltransferase activity. Predicted to be involved in glycoprotein biosynthetic process and mannosylation. Located in fungal-type vacuole. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See KTR4 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 1

Sequence:: Chromosome: II; NC_001134.8 (618909..620303)

Chromosome II - NC_001134.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

KTR4, KTR5 and KTR7 have a redundant activity in the S. cerevisiae N-linked glycosylation pathway, but KTR4 plays a major role in O-linked glycan synthesis.
Title: Saccharomyces cerevisiae KTR4, KTR5 and KTR7 encode mannosyltransferases differentially involved in the N- and O-linked glycosylation pathways.
The crystal structure of the glycosyltransferase Ktr4p from Saccharomyces cerevisiae has been solved.
Title: Structure of the Glycosyltransferase Ktr4p from Saccharomyces cerevisiae.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables alpha-1,2-mannosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables mannosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables mannosyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell wall mannoprotein biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in mannosylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein N-linked glycosylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein N-linked glycosylation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in protein O-linked glycosylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein glycosylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in fungal-type vacuole	HDA more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: putative mannosyltransferase

NP_009758.3

Glycosyltransferase involved in protein glycosylation; transfers GDP-mannose to methyl-alpha-mannoside in vitro; member of the KRE2/MNT1 mannosyltransferase family of type II membrane proteins with a short cytoplasmic N-terminus, a membrane-spanning region and a highly conserved catalytic lumenal domain

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001134.8 Reference assembly

Range

618909..620303

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178547.3 → NP_009758.3 TPA: putative mannosyltransferase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_009758.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VQJ5, P38131, P89506

UniProtKB/TrEMBL

C7GKG0, G2W9K2, N1P8E8

Conserved Domains (1) summary

COG5020
Location:10 → 464

KTR1; Mannosyltransferase [Carbohydrate transport and metabolism]