PTC5 type 2C protein phosphatase PTC5 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: PTC5
Official Full Name: type 2C protein phosphatase PTC5
Primary source: SGD:S000005616
Locus tag: YOR090C
See related: AllianceGenome:SGD:S000005616; FungiDB:YOR090C; VEuPathDB:YOR090C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: PPP1
Summary: Enables [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity. Involved in peptidyl-serine dephosphorylation. Located in mitochondrial intermembrane space. Is active in peroxisome. Human ortholog(s) of this gene implicated in obesity and pyruvate decarboxylase deficiency. Orthologous to human PDP1 (pyruvate dehydrogenase phosphatase catalytic subunit 1) and PDP2 (pyruvate dehydrogenase phosphatase catalytic subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See PTC5 in Genome Data Viewer

Location:: chromosome: XV

Exon count:: 1

Sequence:: Chromosome: XV; NC_001147.6 (491123..492841, complement)

Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Peroxisomal targeting of a protein phosphatase type 2C via mitochondrial transit.
Title: Peroxisomal targeting of a protein phosphatase type 2C via mitochondrial transit.
Deletion of YOR090c, encoding a putative mitochondrial phosphatase, results in a decreased pyruvate dehydrogenase (PDH) activity, indicating that Yor090cp acts as the corresponding PDH phosphatase
Title: YIL042c and YOR090c encode the kinase and phosphatase of the Saccharomyces cerevisiae pyruvate dehydrogenase complex.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity	IEA Inferred from Electronic Annotation more info
enables [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables cation binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphoprotein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in peptidyl-serine dephosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in mitochondrial intermembrane space	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial intermembrane space	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
is_active_in peroxisome	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: type 2C protein phosphatase PTC5

NP_014733.1

EC 3.1.3.43

Mitochondrial type 2C protein phosphatase (PP2C); involved in regulation of pyruvate dehydrogenase activity by dephosphorylating the serine 133 of the Pda1p subunit; localizes to the intermembrane space and is imported via the presequence pathway and processed by the inner membrane protease (Imp1p-Imp2p); acts in concert with kinases Pkp1p and Pkp2p and phosphatase Ptc6p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001147.6 Reference assembly

Range

491123..492841 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183509.1 → NP_014733.1 TPA: type 2C protein phosphatase PTC5 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014733.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W2F1, Q12511

UniProtKB/TrEMBL

N1NWX6

Conserved Domains (1) summary

pfam00481
Location:182 → 464

PP2C; Protein phosphatase 2C