U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    NGL2 RNA exonuclease [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855329, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    NGL2
    Official Full Name
    RNA exonuclease
    Primary source
    SGD:S000004898
    Locus tag
    YMR285C
    See related
    AllianceGenome:SGD:S000004898; FungiDB:YMR285C; VEuPathDB:YMR285C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables RNA endonuclease activity. Involved in rRNA processing. Predicted to be located in cytoplasm. Orthologous to human PDE12 (phosphodiesterase 12). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See NGL2 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (840144..841691, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene tRNA-Tyr Neighboring gene ATP-dependent DNA helicase YKU70 Neighboring gene mitochondrial 54S ribosomal protein YmL33 Neighboring gene exoribonuclease II

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Ngl2p is a Ccr4p-like RNA nuclease essential for the final step in 3'-end processing of 5.8S rRNA in Saccharomyces cerevisiae. Faber AW, et al. RNA, 2002 Sep. PMID 12358428, Free PMC Article
    2. The final step in 5.8S rRNA processing is cytoplasmic in Saccharomyces cerevisiae. Thomson E, et al. Mol Cell Biol, 2010 Feb. PMID 20008552, Free PMC Article
    3. Identification of four families of yCCR4- and Mg2+-dependent endonuclease-related proteins in higher eukaryotes, and characterization of orthologs of yCCR4 with a conserved leucine-rich repeat essential for hCAF1/hPOP2 binding. Dupressoir A, et al. BMC Genomics, 2001. PMID 11747467, Free PMC Article
    4. Toward a functional analysis of the yeast genome through exhaustive two-hybrid screens. Fromont-Racine M, et al. Nat Genet, 1997 Jul. PMID 9207794
    5. Annotating novel genes by integrating synthetic lethals and genomic information. Schöner D, et al. BMC Syst Biol, 2008 Jan 14. PMID 18194531, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA endonuclease activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables poly(A)-specific ribonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in rRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    RNA exonuclease
    NP_014012.1
    • Protein involved in 5.8S rRNA processing; Ccr4p-like RNase required for correct 3'-end formation of 5.8S rRNA at site E; similar to Ngl1p; NGL2 has a paralog, NGL3, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      840144..841691 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182792.1 → NP_014012.1  TPA: RNA exonuclease [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014012.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0B2, Q03264
      UniProtKB/TrEMBL
      A6ZN01, B3LMH3, C7GTL4, C8ZFF2, G2WKZ4, N1NYU3
      Conserved Domains (1) summary
      COG5239
      Location:82 → 515
      CCR4; mRNA deadenylase, 3'-5' endonuclease subunit Ccr4 [RNA processing and modification]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03264.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools