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    putative peptide hydrolase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855141, updated on 9-Dec-2024

    Summary

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    Official Full Name
    putative peptide hydrolase
    Primary source
    SGD:S000004720
    Locus tag
    YMR114C
    See related
    AllianceGenome:SGD:S000004720; FungiDB:YMR114C; VEuPathDB:YMR114C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable lyase activity; peptidase activity; and single-stranded DNA binding activity. Predicted to be involved in protein-DNA covalent cross-linking repair and proteolysis. Located in cytoplasm and nucleus. Orthologous to human HMCES (5-hydroxymethylcytosine binding, ES cell specific). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (496343..497449, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Med11p Neighboring gene dihydrofolate synthase Neighboring gene Mgr3p Neighboring gene ribosomal 40S subunit protein ASC1 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Multiple transcripts from a 3'-UTR reporter vary in sensitivity to nonsense-mediated mRNA decay in Saccharomyces cerevisiae. Zaborske JM, et al. PLoS One, 2013. PMID 24260526, Free PMC Article
    2. Systematic identification and functional screens of uncharacterized proteins associated with eukaryotic ribosomal complexes. Fleischer TC, et al. Genes Dev, 2006 May 15. PMID 16702403, Free PMC Article
    3. A visual screen of protein localization during sporulation identifies new components of prospore membrane-associated complexes in budding yeast. Lam C, et al. Eukaryot Cell, 2014 Mar. PMID 24390141, Free PMC Article
    4. Network Rewiring of Homologous Recombination Enzymes during Mitotic Proliferation and Meiosis. Wild P, et al. Mol Cell, 2019 Aug 22. PMID 31351878, Free PMC Article
    5. Cross-linking Mass Spectrometry Analysis of the Yeast Nucleus Reveals Extensive Protein-Protein Interactions Not Detected by Systematic Two-Hybrid or Affinity Purification-Mass Spectrometry. Bartolec TK, et al. Anal Chem, 2020 Jan 21. PMID 31851481

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in protein-DNA covalent cross-linking repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm HDA PubMed 
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    putative peptide hydrolase
    NP_013832.1
    • hypothetical protein; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR114C is not an essential gene

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      496343..497449 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182614.1 → NP_013832.1  TPA: putative peptide hydrolase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013832.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZT7, Q04471
      UniProtKB/TrEMBL
      A6ZMH1, B3LM05, C8ZEW7, N1P5K2
      Conserved Domains (1) summary
      pfam02586
      Location:1 → 239
      SRAP; SOS response associated peptidase (SRAP)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04471.1

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