Zfp541 zinc finger protein 541 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zfp541provided by MGI
Official Full Name: zinc finger protein 541provided by MGI
Primary source: MGI:MGI:3647699
See related: Ensembl:ENSMUSG00000078796 AllianceGenome:MGI:3647699
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Znf541; EG666528
Summary: Predicted to enable transcription corepressor activity. Involved in male meiotic nuclear division; negative regulation of DNA-templated transcription; and positive regulation of DNA-templated transcription. Located in nucleus. Part of histone deacetylase complex. Is expressed in testis. Orthologous to human ZNF541 (zinc finger protein 541). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward testis adult (RPKM 39.9) See more
Orthologs: human all
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Genomic context

Location:: 7 A2; 7 8.74 cM

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (15795700..15830265)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (16061775..16096340)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ZFP541 and KCTD19 regulate chromatin organization and transcription programs for male meiotic progression.
Title: ZFP541 and KCTD19 regulate chromatin organization and transcription programs for male meiotic progression.
ZFP541 maintains the repression of pre-pachytene transcriptional programs and promotes male meiosis progression.
Title: ZFP541 maintains the repression of pre-pachytene transcriptional programs and promotes male meiosis progression.
KCTD19 and its associated protein ZFP541 are independently essential for meiosis in male mice.
Title: KCTD19 and its associated protein ZFP541 are independently essential for meiosis in male mice.
Meiosis-specific ZFP541 repressor complex promotes developmental progression of meiotic prophase towards completion during mouse spermatogenesis.
Title: Meiosis-specific ZFP541 repressor complex promotes developmental progression of meiotic prophase towards completion during mouse spermatogenesis.
the Mm.290718/ZFP541 complex is implicated in chromatin remodeling during spermatogenesis and is renamed SHIP1
Title: A novel germ cell-specific protein, SHIP1, forms a complex with chromatin remodeling activity during spermatogenesis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in male meiotic nuclear division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in spermatogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of histone deacetylase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of histone deacetylase complex	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: zinc finger protein 541

Names: spermatogenic cell HDAC-interacting protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001099277.2 → NP_001092747.1 zinc finger protein 541 isoform 2

See identical proteins and their annotated locations for NP_001092747.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) has two alternate exons in the 5' coding region compared to variant 1. It encodes a longer protein (isoform 2) compared to isoform 1.

Source sequence(s)

AC151733

Consensus CDS

CCDS39781.1

UniProtKB/Swiss-Prot

B2RXS6, Q0GGX2

Related

ENSMUSP00000104149.2, ENSMUST00000108509.2

Conserved Domains (8) summary

smart00717
Location:1175 → 1219

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

COG5236
Location:80 → 329

COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]

sd00017
Location:142 → 162

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:142 → 162

zf-C2H2; Zinc finger, C2H2 type

pfam01448
Location:1065 → 1120

ELM2; ELM2 domain

pfam13465
Location:154 → 179

zf-H2C2_2; Zinc-finger double domain

pfam13912
Location:168 → 192

zf-C2H2_6; C2H2-type zinc finger

cl21498
Location:1175 → 1218

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
NM_001347559.1 → NP_001334488.1 zinc finger protein 541 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the shorter isoform (1).

Source sequence(s)

AC151733

Consensus CDS

CCDS90162.1

UniProtKB/Swiss-Prot

Q0GGX2

Related

ENSMUSP00000148143.2, ENSMUST00000210805.2

Conserved Domains (6) summary

PHA03247
Location:231 → 677

PHA03247; large tegument protein UL36; Provisional

sd00017
Location:142 → 162

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:168 → 190

zf-C2H2; Zinc finger, C2H2 type

pfam01448
Location:1004 → 1059

ELM2; ELM2 domain

pfam13465
Location:154 → 179

zf-H2C2_2; Zinc-finger double domain

cl21498
Location:1114 → 1157

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

15795700..15830265

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011250674.1 → XP_011248976.1 zinc finger protein 541 isoform X1

See identical proteins and their annotated locations for XP_011248976.1

Conserved Domains (6) summary

PHA03247
Location:231 → 677

PHA03247; large tegument protein UL36; Provisional

sd00017
Location:142 → 162

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:168 → 190

zf-C2H2; Zinc finger, C2H2 type

pfam01448
Location:1010 → 1065

ELM2; ELM2 domain

pfam13465
Location:154 → 179

zf-H2C2_2; Zinc-finger double domain

cl21498
Location:1120 → 1163

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
XM_006540296.3 → XP_006540359.1 zinc finger protein 541 isoform X2

UniProtKB/Swiss-Prot

Q0GGX2

Conserved Domains (6) summary

PHA03247
Location:231 → 677

PHA03247; large tegument protein UL36; Provisional

sd00017
Location:142 → 162

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:168 → 190

zf-C2H2; Zinc finger, C2H2 type

pfam01448
Location:1004 → 1059

ELM2; ELM2 domain

pfam13465
Location:154 → 179

zf-H2C2_2; Zinc-finger double domain

cl21498
Location:1114 → 1157

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
XM_011250677.1 → XP_011248979.1 zinc finger protein 541 isoform X1

See identical proteins and their annotated locations for XP_011248979.1

Conserved Domains (6) summary

PHA03247
Location:231 → 677

PHA03247; large tegument protein UL36; Provisional

sd00017
Location:142 → 162

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:168 → 190

zf-C2H2; Zinc finger, C2H2 type

pfam01448
Location:1010 → 1065

ELM2; ELM2 domain

pfam13465
Location:154 → 179

zf-H2C2_2; Zinc-finger double domain

cl21498
Location:1120 → 1163

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
XM_011250676.2 → XP_011248978.1 zinc finger protein 541 isoform X1

See identical proteins and their annotated locations for XP_011248978.1

Conserved Domains (6) summary

PHA03247
Location:231 → 677

PHA03247; large tegument protein UL36; Provisional

sd00017
Location:142 → 162

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:168 → 190

zf-C2H2; Zinc finger, C2H2 type

pfam01448
Location:1010 → 1065

ELM2; ELM2 domain

pfam13465
Location:154 → 179

zf-H2C2_2; Zinc-finger double domain

cl21498
Location:1120 → 1163

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
XM_011250675.2 → XP_011248977.1 zinc finger protein 541 isoform X1

See identical proteins and their annotated locations for XP_011248977.1

Conserved Domains (6) summary

PHA03247
Location:231 → 677

PHA03247; large tegument protein UL36; Provisional

sd00017
Location:142 → 162

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:168 → 190

zf-C2H2; Zinc finger, C2H2 type

pfam01448
Location:1010 → 1065

ELM2; ELM2 domain

pfam13465
Location:154 → 179

zf-H2C2_2; Zinc-finger double domain

cl21498
Location:1120 → 1163

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
XM_006540295.3 → XP_006540358.1 zinc finger protein 541 isoform X1

See identical proteins and their annotated locations for XP_006540358.1

Conserved Domains (6) summary

PHA03247
Location:231 → 677

PHA03247; large tegument protein UL36; Provisional

sd00017
Location:142 → 162

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:168 → 190

zf-C2H2; Zinc finger, C2H2 type

pfam01448
Location:1010 → 1065

ELM2; ELM2 domain

pfam13465
Location:154 → 179

zf-H2C2_2; Zinc-finger double domain

cl21498
Location:1120 → 1163

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...