Ptdss1 phosphatidylserine synthase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ptdss1provided by RGD
Official Full Name: phosphatidylserine synthase 1provided by RGD
Primary source: RGD:1308949
See related: EnsemblRapid:ENSRNOG00000052289 AllianceGenome:RGD:1308949
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: PSS-1
Summary: Predicted to enable L-serine-phosphatidylcholine phosphatidyltransferase activity and L-serine-phosphatidylethanolamine phosphatidyltransferase activity. Predicted to be involved in phosphatidylserine biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in Lenz-Majewski hyperostotic dwarfism. Orthologous to human PTDSS1 (phosphatidylserine synthase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 221.6), Adrenal (RPKM 207.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q22

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (65730250..65792024)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (63845017..63906791)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (71294140..71356153)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Markers

AU044268 (e-PCR)
- UniSTS:160318

d7rat45 (e-PCR)
- UniSTS:120523

RH130952 (e-PCR)
- UniSTS:214236

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables L-serine-phosphatidylcholine phosphatidyltransferase activity	IEA Inferred from Electronic Annotation more info
enables L-serine-phosphatidylcholine phosphatidyltransferase activity	ISO Inferred from Sequence Orthology more info
enables L-serine-phosphatidylethanolamine phosphatidyltransferase activity	IEA Inferred from Electronic Annotation more info
enables L-serine-phosphatidylethanolamine phosphatidyltransferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in phosphatidylserine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylserine biosynthetic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: phosphatidylserine synthase 1

Names: ptdSer synthase 1; serine-exchange enzyme I

NP_001012113.1

EC 2.7.8.29

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.