Adamts1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Adamts1provided by RGD
Official Full Name: ADAM metallopeptidase with thrombospondin type 1 motif, 1provided by RGD
Primary source: RGD:621241
See related: EnsemblRapid:ENSRNOG00000001607 AllianceGenome:RGD:621241
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable heparin binding activity and metalloendopeptidase activity. Involved in several processes, including cellular response to parathyroid hormone stimulus; cellular response to prostaglandin E stimulus; and cellular response to vitamin D. Located in collagen-containing extracellular matrix. Biomarker of brain ischemia; myocardial infarction; transient cerebral ischemia; ureteral obstruction; and visual epilepsy. Orthologous to human ADAMTS1 (ADAM metallopeptidase with thrombospondin type 1 motif 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Uterus (RPKM 279.8), Kidney (RPKM 216.6) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 11q11

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (38418565..38427384, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (24932227..24941068, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (25342119..25350938, complement)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Expression of placental growth factor and a disintegrin and metalloprotease with a thrombospondin type motifs 1-4-8 during the three trimesters of rat pregnancy at the maternal-fetal interface.
Title: Expression of placental growth factor and a disintegrin and metalloprotease with a thrombospondin type motifs 1-4-8 during the three trimesters of rat pregnancy at the maternal-fetal interface.
A disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS1) was detected by proteomics (the pro- region) in lymph only after LPS
Title: Proteomic evaluation of inflammatory proteins in rat spleen interstitial fluid and lymph during LPS-induced systemic inflammation reveals increased levels of ADAMST1.
Ischemic preconditioning promoted the formation of mature new arteries, which may be modulated by upregulating VEGF, PDGF-B, and ADAMTS-1 expressions.
Title: [Effect of ischemia preconditioning on pro- and anti- angiogenic molecule expression and functional arteries formation].
Cardioprotection with IPC is attenuated in the older heart. ADAMTS-1 expression induced by IPC is greater in old rats. Over-expression of anti-angiogenic factors might be a potential mechanism behind reduced protection after IPC associated with aging.
Title: ADAMTS-1 expression in rat myocardium after ischemic preconditioning: age-associated differences.
Results demonstrate the shear stress-dependent expression of ADAMTS1 in vitro and in vivo and suggest it as a mechanism connecting blood flow with the regulation of angiogenesis.
Title: Expression of ADAMTS1 in endothelial cells is induced by shear stress and suppressed in sprouting capillaries.
Enhanced expression of Adamts1 may predispose the development of chronic kidney reperfusion injury.
Title: Renal ischemia reperfusion inhibits VEGF expression and induces ADAMTS-1, a novel VEGF inhibitor.
Ureteral obstruction-induced expression of ADAMTS-1 in the rat renal tubular epithelial cells may actively contribute to the inhibition of DNA synthesis in the renal interstitial fibroblasts.
Title: Expression and significance of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)-1 in an animal model of renal interstitial fibrosis induced by unilateral ureteral obstruction.
A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)-1 null mutant mice develop renal lesions mimicking obstructive nephropathy. ADAMTS-1 appears necessary for normal kidney morphology and function.
Title: A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)-1 null mutant mice develop renal lesions mimicking obstructive nephropathy.
This study suggests that dental pulp cells, odontoblasts, cementoblasts, cementocytes, periodontal ligament cells, osteoblasts and osteocytes may be involved in both production and degradation of versican with secreting ADAMTS1, ADAMTS4 and ADAMTS5.
Title: Expression of versican and ADAMTS during rat tooth eruption.
ADAMTS-5 mainly contributed to ECM metabolism in growth plate and condylar cartilage during growth. ADAMTS-1 and ADAMTS-4 may be involved in ECM turn over in articular cartilage.
Title: Comparison of age-dependent expression of aggrecan and ADAMTSs in mandibular condylar cartilage, tibial growth plate, and articular cartilage in rats.

Submit: New GeneRIF Correction See all GeneRIFs (12)

General gene information

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Markers

AI237630 (e-PCR)
- UniSTS:250692

A005R14 (e-PCR)
- UniSTS:61779

Adamts1 (e-PCR), detects polymorphism
- UniSTS:532638

Adamts1 (e-PCR), detects polymorphism
- UniSTS:259032

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables heparin binding	IEA Inferred from Electronic Annotation more info
enables heparin binding	ISO Inferred from Sequence Orthology more info
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metalloendopeptidase activity	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase activity	ISO Inferred from Sequence Orthology more info
enables metalloendopeptidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to parathyroid hormone stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to prostaglandin E stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to vitamin D	IEP Inferred from Expression Pattern more info	PubMed
involved_in extracellular matrix organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in extracellular matrix organization	IEA Inferred from Electronic Annotation more info
involved_in heart trabecula formation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within heart trabecula formation	ISO Inferred from Sequence Orthology more info
involved_in kidney development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within kidney development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of angiogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in ovulation from ovarian follicle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ovulation from ovarian follicle	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of G1/S transition of mitotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of vascular associated smooth muscle cell migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of vascular associated smooth muscle cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular associated smooth muscle cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of vascular associated smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in basement membrane	IEA Inferred from Electronic Annotation more info
located_in basement membrane	ISO Inferred from Sequence Orthology more info
located_in collagen-containing extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular matrix	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: A disintegrin and metalloproteinase with thrombospondin motifs 1

Names: ADAM-TS 1; ADAM-TS1; ADAMTS-1; a disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS-1); a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1; a disintegrin-like and metallopeptidse (reprolysin type) with thrombospondin type 1 motif, 1; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 1

NP_077376.2

EC 3.4.24.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_024400.2 → NP_077376.2 A disintegrin and metalloproteinase with thrombospondin motifs 1 precursor

See identical proteins and their annotated locations for NP_077376.2

Status: PROVISIONAL

Source sequence(s)

BC080237

UniProtKB/Swiss-Prot

Q9ERI1, Q9WUQ1

UniProtKB/TrEMBL

F7FAV8, Q68EJ2

Related

ENSRNOP00000002187.4, ENSRNOT00000002187.9

Conserved Domains (6) summary

smart00209
Location:562 → 614

TSP1; Thrombospondin type 1 repeats

cd04273
Location:258 → 463

ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...

pfam01421
Location:258 → 467

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:67 → 168

Pep_M12B_propep; Reprolysin family propeptide

pfam05986
Location:725 → 842

ADAM_spacer1; ADAM-TS Spacer 1

cl15456
Location:468 → 548

ADAM_CR; ADAM cysteine-rich