Slc25a10 solute carrier family 25 member 10 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc25a10provided by RGD
Official Full Name: solute carrier family 25 member 10provided by RGD
Primary source: RGD:621430
See related: EnsemblRapid:ENSRNOG00000036693 AllianceGenome:RGD:621430
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Dic
Summary: Enables malate transmembrane transporter activity and phosphate transmembrane transporter activity. Involved in malate transport and phosphate ion transport. Predicted to be located in mitochondrion and nucleoplasm. Predicted to be active in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome 19. Orthologous to human SLC25A10 (solute carrier family 25 member 10). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 611.4), Adrenal (RPKM 249.3) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q32.3

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (106264396..106271895)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (105765598..105775159)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (109665682..109674782)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The studies also suggest that malate transport by DIC is (1) a critical component of NADPH production mediated by pyruvate-cycling and (2) regulates GSIS.
Title: The dicarboxylate carrier plays a role in mitochondrial malate transport and in the regulation of glucose-stimulated insulin secretion from rat pancreatic beta cells.
Dicarboxylate carrier-mediated glutathione transport is essential for brain mitochondria to maintain reactive oxygen species homeostasis and normal respiratory functions.
Title: Dicarboxylate carrier-mediated glutathione transport is essential for reactive oxygen species homeostasis and normal respiration in rat brain mitochondria.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Slc25a10 (e-PCR), detects polymorphism
- UniSTS:508541

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables antiporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables dicarboxylic acid transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables dicarboxylic acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables malate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables malate transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables malate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables oxaloacetate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphate transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables secondary active transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables succinate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables sulfate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables thiosulfate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in dicarboxylic acid transport	IEA Inferred from Electronic Annotation more info
involved_in glyceraldehyde-3-phosphate biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in lipid transport	IEA Inferred from Electronic Annotation more info
involved_in malate transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in malate transport	IDA Inferred from Direct Assay more info	PubMed
involved_in oxaloacetate transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in oxaloacetate(2-) transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in phosphate ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphate ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in succinate transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in sulfate transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in thiosulfate transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: mitochondrial dicarboxylate carrier

Names: dicarboxylate transporter), member 10; solute carrier family 25 (mitochondrial carrier; solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.