Glb1 galactosidase, beta 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Glb1provided by RGD
Official Full Name: galactosidase, beta 1provided by RGD
Primary source: RGD:1597145
See related: EnsemblRapid:ENSRNOG00000010196 AllianceGenome:RGD:1597145
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables beta-galactosidase activity and galactoside binding activity. Involved in galactose catabolic process; response to Thyroglobulin triiodothyronine; and response to cortisone. Predicted to be located in Golgi apparatus; extracellular space; and lysosome. Predicted to be active in vacuole. Human ortholog(s) of this gene implicated in GM1 gangliosidosis (multiple) and mucopolysaccharidosis IV (multiple). Orthologous to human GLB1 (galactosidase beta 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 491.1), Spleen (RPKM 103.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q32

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (122963718..123036326)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (114085508..114158127)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (122439328..122511939)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A Novel Protocol for Detection of Senescence and Calcification Markers by Fluorescence Microscopy.
Title: A Novel Protocol for Detection of Senescence and Calcification Markers by Fluorescence Microscopy.
Coexpression of wheat germ agglutinin and an axon-targeted beta-galactosidase supports mapping both specific projections of the transduced neurons and identifying specific postsynaptic neurons for the transduced neurons.
Title: Genetic labeling of both the axons of transduced, glutamatergic neurons in rat postrhinal cortex and their postsynaptic neurons in other neocortical areas by herpes simplex virus vectors that coexpress an axon-targeted β-galactosidase and wheat germ agglutinin from a vesicular glutamate transporter-1 promoter.

Submit: New GeneRIF Correction

General gene information

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Markers

RH130801 (e-PCR)
- UniSTS:214085

RH134983 (e-PCR)
- UniSTS:218260

Glb1 (e-PCR), detects polymorphism
- UniSTS:546793

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables beta-galactosidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables beta-galactosidase activity	IDA Inferred from Direct Assay more info	PubMed
enables beta-galactosidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables beta-galactosidase activity	ISO Inferred from Sequence Orthology more info
enables galactoside binding	IDA Inferred from Direct Assay more info	PubMed
enables hydrolase activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in carbohydrate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in galactose catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in galactose catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in ganglioside catabolic process	IEA Inferred from Electronic Annotation more info
involved_in ganglioside catabolic process	ISO Inferred from Sequence Orthology more info
involved_in glycoprotein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in glycoprotein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in keratan sulfate catabolic process	IEA Inferred from Electronic Annotation more info
involved_in keratan sulfate catabolic process	ISO Inferred from Sequence Orthology more info
involved_in response to Thyroglobulin triiodothyronine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to cortisone	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
is_active_in lysosome	ISO Inferred from Sequence Orthology more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in vacuole	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: beta-galactosidase

NP_001101662.1

EC 3.2.1.23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.