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    Slc38a7 solute carrier family 38, member 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 291840, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Slc38a7provided by RGD
    Official Full Name
    solute carrier family 38, member 7provided by RGD
    Primary source
    RGD:1303268
    See related
    EnsemblRapid:ENSRNOG00000012007 AllianceGenome:RGD:1303268
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable L-asparagine:sodium symporter activity and L-glutamine:sodium symporter activity. Predicted to be involved in amino acid transmembrane transport; neutral amino acid transport; and sodium ion transport. Predicted to be located in axon; lysosomal membrane; and neuronal cell body. Predicted to be active in membrane. Orthologous to human SLC38A7 (solute carrier family 38 member 7). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 67.2), Liver (RPKM 37.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Slc38a7 in Genome Data Viewer
    Location:
    19p13
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (9215336..9231592)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (9209203..9225472)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (9622594..9638221)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120098551 Neighboring gene glutamic-oxaloacetic transaminase 2 Neighboring gene uncharacterized LOC102548468 Neighboring gene CCR4-NOT transcription complex, subunit 1 Neighboring gene small nucleolar RNA SNORA50

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of SLC38A7 (SNAT7) protein as a glutamine transporter expressed in neurons. Hägglund MG, et al. J Biol Chem, 2011 Jun 10. PMID 21511949, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC105833

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables L-asparagine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-asparagine:sodium symporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables L-asparagine:sodium symporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables L-glutamine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-glutamine:sodium symporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables L-glutamine:sodium symporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in amino acid transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in asparagine transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in asparagine transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in glutamine transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glutamine transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in inorganic cation transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic cation transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sodium ion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sodium ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in axon ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosomal membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuronal cell body ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    sodium-coupled neutral amino acid transporter 7
    Names
    amino acid transporter
    putative sodium-coupled neutral amino acid transporter 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003705.3 → NP_001003705.1  sodium-coupled neutral amino acid transporter 7

      See identical proteins and their annotated locations for NP_001003705.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/Swiss-Prot
      Q6JWR2
      UniProtKB/TrEMBL
      A6JXZ0
      Conserved Domains (1) summary
      cl00456
      Location:49 → 458
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    2. NM_001434001.1 → NP_001420930.1  sodium-coupled neutral amino acid transporter 7

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      9215336..9231592
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006255067.4 → XP_006255129.1  sodium-coupled neutral amino acid transporter 7 isoform X1

      UniProtKB/Swiss-Prot
      Q6JWR2
      UniProtKB/TrEMBL
      A6JXZ0
      Related
      ENSRNOP00000058216.1, ENSRNOT00000061498.5
      Conserved Domains (1) summary
      cl00456
      Location:49 → 458
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    2. XM_063277841.1 → XP_063133911.1  sodium-coupled neutral amino acid transporter 7 isoform X2

    3. XM_063277842.1 → XP_063133912.1  sodium-coupled neutral amino acid transporter 7 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6JWR2.1 GenPept UniProtKB/Swiss-Prot:Q6JWR2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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