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    fecA ferric citrate outer membrane transporter [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946427, updated on 3-Dec-2024

    Summary

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    Official Symbol
    fecA
    Official Full Name
    ferric citrate outer membrane transporter
    Primary source
    ECOCYC:EG10286
    Locus tag
    b4291
    See related
    ASAP:ABE-0014067
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK4281
    Summary
    FecA is the TonB energy transducing system-dependent ferric citrate uptake receptor. [More information is available at EcoCyc: EG10286].
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    Genomic context

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    Sequence:
    NC_000913.3 (4514353..4516677, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene ferric citrate ABC transporter membrane subunit FecD Neighboring gene ferric citrate ABC transporter membrane subunit FecC Neighboring gene ferric citrate ABC transporter periplasmic binding protein Neighboring gene ferric citrate regulator FecR Neighboring gene RNA polymerase sigma factor FecI Neighboring gene protein YkiE

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Conformational dynamics and membrane interactions of the E. coli outer membrane protein FecA: a molecular dynamics simulation study. Piggot TJ, et al. Biochim Biophys Acta, 2013 Feb. PMID 22960041
    2. Predicting the complex structure and functional motions of the outer membrane transporter and signal transducer FecA. Sen TZ, et al. Biophys J, 2008 Apr 1. PMID 18178655, Free PMC Article
    3. Close before opening. Postle K. Science, 2002 Mar 1. PMID 11872826
    4. Structural basis of gating by the outer membrane transporter FecA. Ferguson AD, et al. Science, 2002 Mar 1. PMID 11872840
    5. Bipartite gating in the outer membrane protein FecA. van der Helm D, et al. Biochem Soc Trans, 2002 Aug. PMID 12196171

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. fecA gene plays a role in ethanol tolerance.
      Title: A Recurrent Silent Mutation Implicates fecA in Ethanol Tolerance by Escherichia coli.
    2. analysis of conformational dynamics and membrane interactions of the E. coli outer membrane protein FecA
      Title: Conformational dynamics and membrane interactions of the E. coli outer membrane protein FecA: a molecular dynamics simulation study.
    3. High concentrations of stabilizing solutes, such as those used to generate membrane protein crystals, result in a more compact and ordered state of the protein than is seen under more physiological conditions.
      Title: Solutes alter the conformation of the ligand binding loops in outer membrane transporters.
    4. N-terminus verified by Edman degradation on mature peptide
      Title: Genetics of the iron dicitrate transport system of Escherichia coli.
    5. NMR solution structure presented of periplasmic signaling n-terminal domain including TonB box region
      Title: Nuclear magnetic resonance solution structure of the periplasmic signalling domain of the TonB-dependent outer membrane transporter FecA from Escherichia coli.
    6. Results indicate that FecA N-terminal domain interferes with TonB-CTD binding to the TonB box.
      Title: Characterization of TonB interactions with the FepA cork domain and FecA N-terminal signaling domain.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables siderophore-iron transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables signaling receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular iron ion homeostasis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in iron ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to iron ion starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in siderophore transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in siderophore transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in siderophore-dependent iron import into cell IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in siderophore-dependent iron import into cell IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within siderophore-dependent iron import into cell IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within signal transduction involved in regulation of gene expression TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cell outer membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of transmembrane transporter complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ferric citrate outer membrane transporter

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4514353..4516677 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418711.1 ferric citrate outer membrane transporter [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418711.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376JT15, A0A7A7FTL0, A0A8T6B9P6
      Conserved Domains (1) summary
      COG4772
      Location:51 → 774
      FecA; Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version

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