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    wzxC colanic acid repeat unit flippase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946581, updated on 17-Dec-2024

    Summary

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    Official Symbol
    wzxC
    Official Full Name
    colanic acid repeat unit flippase
    Primary source
    ECOCYC:G7097
    Locus tag
    b2046
    See related
    ASAP:ABE-0006783
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2040; wzx
    Summary
    Wzx is an uncharacterized member of the Polysaccharide Transporter (PST) family . [More information is available at EcoCyc: G7097].
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    Genomic context

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    Sequence:
    NC_000913.3 (2118680..2120158, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative colanic acid biosynthesis protein WcaM Neighboring gene putative colanic acid biosynthesis glycosyl transferase WcaL Neighboring gene colanic acid biosynthesis pyruvyl transferase WcaK Neighboring gene UDP-glucose:undecaprenyl-phosphate glucose-1-phosphate transferase Neighboring gene phosphomannomutase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Membrane topology and identification of critical amino acid residues in the Wzx O-antigen translocase from Escherichia coli O157:H4. Marolda CL, et al. J Bacteriol, 2010 Dec. PMID 20870764, Free PMC Article
    2. Computer-based analyses of the protein constituents of transport systems catalysing export of complex carbohydrates in bacteria. Paulsen IT, et al. Microbiology (Reading), 1997 Aug. PMID 9274022
    3. Biosynthesis and assembly of capsular polysaccharides in Escherichia coli. Whitfield C. Annu Rev Biochem, 2006. PMID 16756484
    4. Development of a biofilm production-deficient Escherichia coli strain as a host for biotechnological applications. Sung BH, et al. Appl Environ Microbiol, 2006 May. PMID 16672475, Free PMC Article
    5. Loss of specificity variants of WzxC suggest that substrate recognition is coupled with transporter opening in MOP-family flippases. Sham LT, et al. Mol Microbiol, 2018 Sep. PMID 29907971, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the ability of WzxC variants to suppress MurJ inactivation provides strong support for the designation of MurJ as the flippase for peptidoglycan precursors, the identity of which has been controversial.
      Title: Loss of specificity variants of WzxC suggest that substrate recognition is coupled with transporter opening in MOP-family flippases.
    2. The authors conclude that Wzx(EcO157) consists of 12 transmembrane (TM) helices and six periplasmic and five cytosolic loops, with N and C termini facing the cytoplasm.
      Title: Membrane topology and identification of critical amino acid residues in the Wzx O-antigen translocase from Escherichia coli O157:H4.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Process Evidence Code Pubs
    acts_upstream_of_or_within colanic acid biosynthetic process IGC
    Inferred from Genomic Context
    more info
    		 PubMed 
    acts_upstream_of_or_within colanic acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipopolysaccharide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    colanic acid repeat unit flippase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2118680..2120158 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416550.1 colanic acid repeat unit flippase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416550.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A7A2LKN5
      Conserved Domains (1) summary
      PRK10459
      Location:1 → 492
      PRK10459; MOP flippase family protein
    Nucleotide Protein
    Heading Accession and Version

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