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    fecD ferric citrate ABC transporter membrane subunit FecD [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946816, updated on 3-Dec-2024

    Summary

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    Official Symbol
    fecD
    Official Full Name
    ferric citrate ABC transporter membrane subunit FecD
    Primary source
    ECOCYC:EG10289
    Locus tag
    b4288
    See related
    ASAP:ABE-0014059
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK4278
    Summary
    Probable false positive lipoprotein prediction, 9 CM TMs predicted, Cys not conserved. [More information is available at EcoGene: EG10289]. FecD is one of two (along with FecC) integral membrane protein components of the iron dicitrate ABC transporter. [More information is available at EcoCyc: EG10289].
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    Genomic context

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    Sequence:
    NC_000913.3 (4511458..4512414, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene ferric citrate ABC transporter ATP binding subunit Neighboring gene ferric citrate ABC transporter membrane subunit FecC Neighboring gene ferric citrate ABC transporter periplasmic binding protein Neighboring gene ferric citrate outer membrane transporter

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Citrate-dependent iron transport system in Escherichia coli K-12. Hussein S, et al. Eur J Biochem, 1981 Jul. PMID 6268411
    2. Genetics of the iron dicitrate transport system of Escherichia coli. Pressler U, et al. J Bacteriol, 1988 Jun. PMID 2836368, Free PMC Article
    3. Ferric citrate transport in Escherichia coli requires outer membrane receptor protein fecA. Wagegg W, et al. J Bacteriol, 1981 Jan. PMID 7007312, Free PMC Article
    4. Docking of the periplasmic FecB binding protein to the FecCD transmembrane proteins in the ferric citrate transport system of Escherichia coli. Braun V, et al. J Bacteriol, 2007 Oct. PMID 17660286, Free PMC Article
    5. Localization of the entire fec region at 97.3 minutes on the Escherichia coli K-12 chromosome. Veitinger S, et al. J Bacteriol, 1992 Jun. PMID 1592838, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SDS results suggest cross-linking of FecB(E93C) to FecD(R54C) and that FecB(E93) is contained in the region that binds to FecD and FecB(E222) in the region that binds to FecC.
      Title: Docking of the periplasmic FecB binding protein to the FecCD transmembrane proteins in the ferric citrate transport system of Escherichia coli.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables iron chelate transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular iron ion homeostasis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in iron import into cell NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in iron ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in siderophore-dependent iron import into cell IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within siderophore-dependent iron import into cell IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ferric citrate ABC transporter membrane subunit FecD
    NP_418708.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4511458..4512414 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418708.1 ferric citrate ABC transporter membrane subunit FecD [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418708.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A0H3MNJ1
      Conserved Domains (1) summary
      PRK09777
      Location:1 → 318
      fecD; Fe(3+) dicitrate ABC transporter permease subunit FecD
    Nucleotide Protein
    Heading Accession and Version

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