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    cusS sensor histidine kinase CusS [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945978, updated on 3-Dec-2024

    Summary

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    Official Symbol
    cusS
    Official Full Name
    sensor histidine kinase CusS
    Primary source
    ECOCYC:G6318
    Locus tag
    b0570
    See related
    ASAP:ABE-0001946
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0562; ybcZ
    Summary
    The cusABFCRS gene cluster has similarity to a gene cluster contained on a silver resistance plasmid from a clinical Salmonella isolate . [More information is available at EcoCyc: G6318].
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    Genomic context

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    Sequence:
    NC_000913.3 (593328..594770, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative exopolysaccharide secretion system auxiliary component Neighboring gene exopolysaccharide secretion system outer membrane protein NfrA Neighboring gene cyclic di-3',5'-guanylate-activated glycosyltransferase Neighboring gene DNA-binding transcriptional activator CusR Neighboring gene copper/silver export system outer membrane channel Neighboring gene copper/silver export system periplasmic binding protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mechanism of metal ion-induced activation of a two-component sensor kinase. Affandi T, et al. Biochem J, 2019 Jan 15. PMID 30530842, Free PMC Article
    2. Regulation of Cu(I)/Ag(I) efflux genes in Escherichia coli by the sensor kinase CusS. Gudipaty SA, et al. FEMS Microbiol Lett, 2012 May. PMID 22348296, Free PMC Article
    3. Metal-induced sensor mobilization turns on affinity to activate regulator for metal detoxification in live bacteria. Fu B, et al. Proc Natl Acad Sci U S A, 2020 Jun 16. PMID 32467170, Free PMC Article
    4. Identification of a copper-responsive two-component system on the chromosome of Escherichia coli K-12. Munson GP, et al. J Bacteriol, 2000 Oct. PMID 11004187, Free PMC Article
    5. Bacterial silver resistance: molecular biology and uses and misuses of silver compounds. Silver S. FEMS Microbiol Rev, 2003 Jun. PMID 12829274

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Metal-induced sensor mobilization turns on affinity to activate regulator for metal detoxification in live bacteria.
      Title: Metal-induced sensor mobilization turns on affinity to activate regulator for metal detoxification in live bacteria.
    2. Mechanism of metal ion-induced activation of a two-component sensor kinase.
      Title: Mechanism of metal ion-induced activation of a two-component sensor kinase.
    3. investigation pf the roles of CusS transmembrane (TM) residues; findings suggest that destabilization of an intramolecular constraint and a subsequent rearrangement of helical interactions in this TM region is involved in the activation of CusS; these results suggested a conserved transmembrane signal transduction mechanism in the heavy metal sensing two-component systems
      Title: Signaling by the heavy-metal sensor CusS involves rearranged helical interactions in specific transmembrane regions.
    4. These results show a metal-dependent mechanism of CusS activation and suggest an absolute requirement for CusS in Cu(I)- and Ag(I)-dependent upregulation of cusCFBA expression in Escherichia coli.
      Title: Regulation of Cu(I)/Ag(I) efflux genes in Escherichia coli by the sensor kinase CusS.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables phosphorelay sensor kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphorelay sensor kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein histidine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to copper ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cellular response to silver ion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within cellular response to silver ion IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within cellular response to silver ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phosphorelay signal transduction system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphorelay signal transduction system IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in outer membrane-bounded periplasmic space RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sensor histidine kinase CusS
    NP_415102.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      593328..594770 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415102.1 sensor histidine kinase CusS [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415102.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A418G9F6
      Conserved Domains (1) summary
      PRK09835
      Location:1 → 479
      PRK09835; Cu(+)/Ag(+) sensor histidine kinase
    Nucleotide Protein
    Heading Accession and Version

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