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    yghJ putative lipoprotein YghJ [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 2847716, updated on 3-Dec-2024

    Summary

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    Official Symbol
    yghJ
    Official Full Name
    putative lipoprotein YghJ
    Primary source
    ECOCYC:G7541
    Locus tag
    b4466
    See related
    ASAP:ABE-0174096
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    b2973; b2974; ECK2968; sslE
    Summary
    YghJ is homologous to V. cholerae accessory colonization factor AcfD. [More information is available at EcoGene: EG12994]. YghJ is a hypothetical protein. [More information is available at EcoCyc: G7541].
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    Genomic context

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    Sequence:
    NC_000913.3 (3114550..3119112, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene lipoprotein YghG Neighboring gene prepilin peptidase Neighboring gene glycolate/lactate:H(+) symporter GlcA Neighboring gene malate synthase G

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Linking inherent O-Linked Protein Glycosylation of YghJ to Increased Antigen Potential. Thorsing M, et al. Front Cell Infect Microbiol, 2021. PMID 34490144, Free PMC Article
    2. Differential Regulation of the Surface-Exposed and Secreted SslE Lipoprotein in Extraintestinal Pathogenic Escherichia coli. Tan L, et al. PLoS One, 2016. PMID 27598999, Free PMC Article
    3. SslE elicits functional antibodies that impair in vitro mucinase activity and in vivo colonization by both intestinal and extraintestinal Escherichia coli strains. Nesta B, et al. PLoS Pathog, 2014 May. PMID 24809621, Free PMC Article
    4. Enterotoxigenic Escherichia coli secretes a highly conserved mucin-degrading metalloprotease to effectively engage intestinal epithelial cells. Luo Q, et al. Infect Immun, 2014 Feb. PMID 24478067, Free PMC Article
    5. Transposition is modulated by a diverse set of host factors in Escherichia coli and is stimulated by nutritional stress. Twiss E, et al. Mol Microbiol, 2005 Sep. PMID 16135227

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Linking inherent O-Linked Protein Glycosylation of YghJ to Increased Antigen Potential.
      Title: Linking inherent O-Linked Protein Glycosylation of YghJ to Increased Antigen Potential.
    2. SslE promotes macrophage activation and M1 polarization, which are crucial in framing the host's innate immune response to this protein.
      Title: SslE (YghJ), a Cell-Associated and Secreted Lipoprotein of Neonatal Septicemic Escherichia coli, Induces Toll-Like Receptor 2-Dependent Macrophage Activation and Proinflammation through NF-κB and MAP Kinase Signaling.
    3. Differential regulation of the surface-exposed and secreted SslE lipoprotein in extraintestinal pathogenic Escherichia coli has been reported.
      Title: Differential Regulation of the Surface-Exposed and Secreted SslE Lipoprotein in Extraintestinal Pathogenic Escherichia coli.
    4. The authors showed that YghJ can cause extensive tissue damage in mouse ileum and is also able to induce significant fluid accumulation in a dose dependent manner in a mouse ileal loop (MIL) assay.
      Title: YghJ, the secreted metalloprotease of pathogenic E. coli induces hemorrhagic fluid accumulation in mouse ileal loop.
    5. SslE expression not only increases bacterial growth in the presence of mucosal substrates but it also facilitates E. coli penetration of the mucus.
      Title: Pathogenic E. coli exploits SslE mucinase activity to translocate through the mucosal barrier and get access to host cells.
    6. Importance of SslE in E. coli colonization of mucosal surfaces, which reinforce the use of this antigen as a component of a broadly protective vaccine against pathogenic E. coli species.
      Title: SslE elicits functional antibodies that impair in vitro mucinase activity and in vivo colonization by both intestinal and extraintestinal Escherichia coli strains.
    7. YghJ is a highly conserved metalloprotease that influences intestinal colonization of enterotoxigenic Escherichia coli by degrading the major mucins in the small intestine, MUC2 and MUC3.
      Title: Enterotoxigenic Escherichia coli secretes a highly conserved mucin-degrading metalloprotease to effectively engage intestinal epithelial cells.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables transmembrane transporter binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative lipoprotein YghJ

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3114550..3119112 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. YP_026189.1 putative lipoprotein YghJ [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for YP_026189.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S7U9D3
      Conserved Domains (1) summary
      NF037974
      Location:106 → 1511
      SslE_AcfD_Zn_LP; SslE/AcfD family lipoprotein zinc metalloprotease
    Nucleotide Protein
    Heading Accession and Version

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