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    fecR ferric citrate regulator FecR [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 949104, updated on 3-Dec-2024

    Summary

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    Official Symbol
    fecR
    Official Full Name
    ferric citrate regulator FecR
    Primary source
    ECOCYC:EG10292
    Locus tag
    b4292
    See related
    ASAP:ABE-0014070
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK4282
    Summary
    Mutant has increased aggregation. [More information is available at EcoGene: EG10292]. FecARI are responsible for ferric citrate dependent induction of the ferric citrate uptake system. [More information is available at EcoCyc: EG10292].
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    Genomic context

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    Sequence:
    NC_000913.3 (4516764..4517717, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene ferric citrate ABC transporter membrane subunit FecC Neighboring gene ferric citrate ABC transporter periplasmic binding protein Neighboring gene ferric citrate outer membrane transporter Neighboring gene RNA polymerase sigma factor FecI Neighboring gene protein YkiE Neighboring gene IS1 family repressor protein InsA Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transcription induction of the ferric citrate transport genes via the N-terminus of the FecA outer membrane protein, the Ton system and the electrochemical potential of the cytoplasmic membrane. Kim I, et al. Mol Microbiol, 1997 Jan. PMID 9044267
    2. Ferric citrate transport of Escherichia coli: functional regions of the FecR transmembrane regulatory protein. Welz D, et al. J Bacteriol, 1998 May. PMID 9573190, Free PMC Article
    3. Residues involved in FecR binding are localized on one side of the FecA signaling domain in Escherichia coli. Breidenstein E, et al. J Bacteriol, 2006 Sep. PMID 16923915, Free PMC Article
    4. Ferric Citrate Regulator FecR Is Translocated across the Bacterial Inner Membrane via a Unique Twin-Arginine Transport-Dependent Mechanism. Passmore IJ, et al. J Bacteriol, 2020 Apr 9. PMID 32015149, Free PMC Article
    5. Transcription of the region encoding the ferric dicitrate-transport system in Escherichia coli: similarity between promoters for fecA and for extracytoplasmic function sigma factors. Enz S, et al. Gene, 1995 Sep 22. PMID 7557462

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ferric Citrate Regulator FecR Is Translocated across the Bacterial Inner Membrane via a Unique Twin-Arginine Transport-Dependent Mechanism.
      Title: Ferric Citrate Regulator FecR Is Translocated across the Bacterial Inner Membrane via a Unique Twin-Arginine Transport-Dependent Mechanism.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sigma factor antagonist activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane signaling receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within intracellular iron ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in iron ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription initiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within signal transduction involved in regulation of gene expression TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ferric citrate regulator FecR

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4516764..4517717 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418712.1 ferric citrate regulator FecR [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418712.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8T5YHB9
      Conserved Domains (1) summary
      PRK09774
      Location:1 → 316
      PRK09774; fec operon regulator FecR; Reviewed
    Nucleotide Protein
    Heading Accession and Version

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