Txn2 thioredoxin 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Txn2provided by MGI
Official Full Name: thioredoxin 2provided by MGI
Primary source: MGI:MGI:1929468
See related: Ensembl:ENSMUSG00000005354 AllianceGenome:MGI:1929468
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Trx2; 2510006J11Rik
Summary: Predicted to contribute to peptide-methionine (R)-S-oxide reductase activity; peptide-methionine (S)-S-oxide reductase activity; and protein-disulfide reductase activity. Predicted to be involved in cell redox homeostasis. Located in mitochondrion. Is expressed in future spinal cord; heart; heart apex; spinal cord; and spinal cord white matter. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 29. Orthologous to human TXN2 (thioredoxin 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in adrenal adult (RPKM 463.2), duodenum adult (RPKM 177.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 E1; 15 36.92 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (77799251..77813194, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (77915051..77928994, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Zbtb16 increases susceptibility of atrial fibrillation in type 2 diabetic mice via Txnip-Trx2 signaling.
Title: Zbtb16 increases susceptibility of atrial fibrillation in type 2 diabetic mice via Txnip-Trx2 signaling.
scAAV2-Mediated Expression of Thioredoxin 2 and C3 Transferase Prevents Retinal Ganglion Cell Death and Lowers Intraocular Pressure in a Mouse Model of Glaucoma.
Title: scAAV2-Mediated Expression of Thioredoxin 2 and C3 Transferase Prevents Retinal Ganglion Cell Death and Lowers Intraocular Pressure in a Mouse Model of Glaucoma.
Brown adipose TRX2 deficiency activates mtDNA-NLRP3 to impair thermogenesis and protect against diet-induced insulin resistance.
Title: Brown adipose TRX2 deficiency activates mtDNA-NLRP3 to impair thermogenesis and protect against diet-induced insulin resistance.
Mitochondrial thioredoxin-2 maintains HCN4 expression and prevents oxidative stress-mediated sick sinus syndrome.
Title: Mitochondrial thioredoxin-2 maintains HCN4 expression and prevents oxidative stress-mediated sick sinus syndrome.
Thioredoxin-2 impacts the inflammatory response via suppression of NF-kappaB and MAPK signaling in sepsis shock.
Title: Thioredoxin-2 impacts the inflammatory response via suppression of NF-κB and MAPK signaling in sepsis shock.
Loss of TXN2 alters mitochondrial respiratory function and induces cardiomyocyte hypertrophy.
Title: Loss of thioredoxin 2 alters mitochondrial respiratory function and induces cardiomyocyte hypertrophy.
The ventral signal observed from early stages colocalized with motor neuron markers Isl1/2 and FoxP1 and the strong ventral signal colocalizing with Isl1/2 was observed in all rostrocaudal segments of the spinal cord.
Title: Expression of peroxiredoxins and thioredoxins in the mouse spinal cord during embryonic development.
TRX-2 overexpression does not mitigate adverse effects of a high-calorie diet on synaptic plasticity
Title: Thidoredxin-2 overexpression fails to rescue chronic high calorie diet induced hippocampal dysfunction.
An essential role was identified for thioredoxin-2 in preserving cardiac function by suppressing mitochondrial reactive oxygen species.
Title: Thioredoxin-2 inhibits mitochondrial reactive oxygen species generation and apoptosis stress kinase-1 activity to maintain cardiac function.
The SirT1 regulates the expression of several antioxidant genes in bovine aortic endothelial cells, including Mn superoxide dismutase, catalase, peroxiredoxins 3 and 5, thioredoxin 2, thioredoxin reductase 2, and uncoupling protein 2.
Title: SirT1 regulation of antioxidant genes is dependent on the formation of a FoxO3a/PGC-1α complex.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (1) 1 citation
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables peptide-methionine (R)-S-oxide reductase activity	IEA Inferred from Electronic Annotation more info
contributes_to peptide-methionine (R)-S-oxide reductase activity	ISO Inferred from Sequence Orthology more info
enables peptide-methionine (S)-S-oxide reductase activity	IEA Inferred from Electronic Annotation more info
contributes_to peptide-methionine (S)-S-oxide reductase activity	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables protein-disulfide reductase activity	IEA Inferred from Electronic Annotation more info
contributes_to protein-disulfide reductase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell redox homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to nutrient levels	IEA Inferred from Electronic Annotation more info
involved_in response to axon injury	IEA Inferred from Electronic Annotation more info
involved_in response to glucose	IEA Inferred from Electronic Annotation more info
involved_in response to hormone	IEA Inferred from Electronic Annotation more info
involved_in response to hypoxia	IEA Inferred from Electronic Annotation more info
involved_in response to organic cyclic compound	IEA Inferred from Electronic Annotation more info
involved_in response to oxidative stress	IEA Inferred from Electronic Annotation more info
involved_in response to xenobiotic stimulus	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: thioredoxin, mitochondrial

Names: MTRX; mt-Trx; thioredoxin nuclear gene encoding mitochondrial protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019913.5 → NP_064297.1 thioredoxin, mitochondrial precursor

See identical proteins and their annotated locations for NP_064297.1

Status: PROVISIONAL

Source sequence(s)

AL583886

Consensus CDS

CCDS27606.1

UniProtKB/Swiss-Prot

A2A440, P97493, Q545D5

Related

ENSMUSP00000005487.6, ENSMUST00000005487.12

Conserved Domains (1) summary

cd02947
Location:72 → 162

TRX_family; TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox ...