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    Cxcr4 C-X-C motif chemokine receptor 4 [ Mus musculus (house mouse) ]

    Gene ID: 12767, updated on 3-Dec-2024

    Summary

    Official Symbol
    Cxcr4provided by MGI
    Official Full Name
    C-X-C motif chemokine receptor 4provided by MGI
    Primary source
    MGI:MGI:109563
    See related
    Ensembl:ENSMUSG00000045382 AllianceGenome:MGI:109563
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CD184; LESTR; Sdf1r; CXC-R4; CXCR-4; Cmkar4; PB-CKR; b2b220Clo; PBSF/SDF-1
    Summary
    Predicted to enable several functions, including chemokine receptor activity; cytoskeletal protein binding activity; and ubiquitin protein ligase binding activity. Involved in several processes, including nervous system development; positive regulation of cold-induced thermogenesis; and positive regulation of oligodendrocyte differentiation. Acts upstream of or within several processes, including CXCL12-activated CXCR4 signaling pathway; circulatory system development; and nervous system development. Located in cell-cell junction; external side of plasma membrane; and growth cone. Is expressed in several structures, including alimentary system; cardiovascular system; embryo mesenchyme; extraembryonic component; and nervous system. Used to study WHIM syndrome 1; cardiomyopathy; and congestive heart failure. Human ortholog(s) of this gene implicated in several diseases, including WHIM syndrome 1; bone disease (multiple); hematologic cancer (multiple); pancreatic adenocarcinoma; and prostate cancer. Orthologous to human CXCR4 (C-X-C motif chemokine receptor 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in thymus adult (RPKM 230.6), spleen adult (RPKM 93.9) and 10 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Cxcr4 in Genome Data Viewer
    Location:
    1 E4; 1 56.43 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (128515936..128520036, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (128588199..128592299, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4344 Neighboring gene STARR-positive B cell enhancer ABC_E2558 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:130487786-130488065 Neighboring gene STARR-positive B cell enhancer ABC_E10032 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:130502453-130502636 Neighboring gene STARR-positive B cell enhancer ABC_E4345 Neighboring gene STARR-positive B cell enhancer ABC_E10033 Neighboring gene STARR-positive B cell enhancer ABC_E7744 Neighboring gene predicted gene, 41950 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E9477 Neighboring gene STARR-seq mESC enhancer starr_02173 Neighboring gene STARR-seq mESC enhancer starr_02174 Neighboring gene STARR-positive B cell enhancer ABC_E2007 Neighboring gene STARR-seq mESC enhancer starr_02175 Neighboring gene STARR-seq mESC enhancer starr_02176 Neighboring gene STARR-seq mESC enhancer starr_02178 Neighboring gene STARR-seq mESC enhancer starr_02179 Neighboring gene predicted gene, 23056 Neighboring gene STARR-seq mESC enhancer starr_02180 Neighboring gene STARR-seq mESC enhancer starr_02181 Neighboring gene STARR-seq mESC enhancer starr_02182 Neighboring gene STARR-seq mESC enhancer starr_02183 Neighboring gene STARR-seq mESC enhancer starr_02184 Neighboring gene thrombospondin, type I, domain containing 7B Neighboring gene STARR-seq mESC enhancer starr_02185 Neighboring gene predicted gene, 36347

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables C-C chemokine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables C-C chemokine binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables C-C chemokine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables C-X-C motif chemokine 12 receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables C-X-C motif chemokine 12 receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables actin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cytokine binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables myosin light chain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables small molecule binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within CXCL12-activated CXCR4 signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in CXCL12-activated CXCR4 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in CXCL12-activated CXCR4 signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within T cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within ameboidal-type cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in animal organ morphogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within aorta development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within blood vessel endothelial cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in brain development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within brain development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within branching involved in blood vessel morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in calcium-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within calcium-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in cardiac muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cellular response to cytokine stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to cytokine stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to cytokine stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in detection of mechanical stimulus involved in sensory perception of pain ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in detection of temperature stimulus involved in sensory perception of pain ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endothelial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endothelial tube morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in epithelial cell development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in generation of neurons IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within germ cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within germ cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within hematopoietic stem cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within kidney development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within motor neuron axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in myelin maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in nervous system development TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in neural precursor cell proliferation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in neurogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in neurogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within neuron migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in neuron migration ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of calcium ion import IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cold-induced thermogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cytosolic calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of dendrite extension ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of macrophage migration inhibitory factor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of mesenchymal stem cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neurogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of oligodendrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of vascular wound healing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of vasculature development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of cell migration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of programmed cell death ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of viral process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to organic cyclic compound ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to tacrolimus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in telencephalon cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within ventricular septum development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell leading edge ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in cell-cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with early endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in early endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in growth cone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in late endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in late endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    colocalizes_with lysosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lysosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    C-X-C chemokine receptor type 4
    Names
    SDF-1 receptor
    chemokine (C-X-C motif) receptor 4
    chemokine (C-X-C) receptor 4
    chemokine receptor 4
    fusin
    leukocyte-derived seven transmembrane domain receptor
    leukocyte-expressed seven-transmembrane-domain
    pre-B-cell-derived chemokine receptor
    stromal cell-derived factor 1 receptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356509.1NP_001343438.1  C-X-C chemokine receptor type 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC161170
      UniProtKB/Swiss-Prot
      O09059, O09062, P70233, P70346, P70658, Q4KMW1
      Conserved Domains (2) summary
      pfam12109
      Location:638
      CXCR4_N; CXCR4 Chemokine receptor N terminal
      cd15179
      Location:39318
      7tmA_CXCR4; CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors
    2. NM_001420067.1NP_001406996.1  C-X-C chemokine receptor type 4 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC161170
      UniProtKB/Swiss-Prot
      O09059, O09062, P70233, P70346, P70658, Q4KMW1
    3. NM_001420068.1NP_001406997.1  C-X-C chemokine receptor type 4 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC161170
      UniProtKB/Swiss-Prot
      O09059, O09062, P70233, P70346, P70658, Q4KMW1
    4. NM_009911.4NP_034041.2  C-X-C chemokine receptor type 4 isoform 1

      See identical proteins and their annotated locations for NP_034041.2

      Status: VALIDATED

      Source sequence(s)
      AC161170
      Consensus CDS
      CCDS15254.1
      UniProtKB/Swiss-Prot
      O09059, O09062, P70233, P70346, P70658, Q4KMW1
      UniProtKB/TrEMBL
      A0A0R4J0N8
      Related
      ENSMUSP00000053489.7, ENSMUST00000052172.7
      Conserved Domains (2) summary
      pfam00001
      Location:57309
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      pfam12109
      Location:840
      CXCR4_N; CXCR4 Chemokine receptor N terminal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      128515936..128520036 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)