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    VPS55 Vps55p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853502, updated on 9-Dec-2024

    Summary

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    Official Symbol
    VPS55
    Official Full Name
    Vps55p
    Primary source
    SGD:S000003805
    Locus tag
    YJR044C
    See related
    AllianceGenome:SGD:S000003805; FungiDB:YJR044C; VEuPathDB:YJR044C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in late endosome to vacuole transport via multivesicular body sorting pathway. Located in late endosome. Part of Vps55/Vps68 complex. Orthologous to several human genes including LEPROTL1 (leptin receptor overlapping transcript like 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See VPS55 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (518763..519185, complement)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene DNA polymerase delta subunit POL32 Neighboring gene tRNA-Met Neighboring gene Hsp70 family ATPase SSC1 Neighboring gene Tah11p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutants defective in secretory/vacuolar pathways in the EUROFAN collection of yeast disruptants. Avaro S, et al. Yeast, 2002 Mar 15. PMID 11870858
    2. Yeast Vps55p, a functional homolog of human obesity receptor gene-related protein, is involved in late endosome to vacuole trafficking. Belgareh-Touzé N, et al. Mol Biol Cell, 2002 May. PMID 12006663, Free PMC Article
    3. Global analysis of yeast endosomal transport identifies the vps55/68 sorting complex. Schluter C, et al. Mol Biol Cell, 2008 Apr. PMID 18216282, Free PMC Article
    4. Interaction between ESCRT-III proteins and the yeast SERINC homolog Tms1. Kölling R. Genetics, 2024 Oct 7. PMID 39271159
    5. A PX-BAR protein Mvp1/SNX8 and a dynamin-like GTPase Vps1 drive endosomal recycling. Suzuki SW, et al. Elife, 2021 Sep 15. PMID 34524084, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Vps55p and Vps68p form a complex that acts with or downstream of ESCRT function to regulate endosomal trafficking.
      Title: Global analysis of yeast endosomal transport identifies the vps55/68 sorting complex.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in late endosome to vacuole transport via multivesicular body sorting pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in late endosome to vacuole transport via multivesicular body sorting pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Vps55/Vps68 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Vps55/Vps68 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Vps55/Vps68 complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in late endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Vps55p
    NP_012578.3
    • Late endosomal protein involved in late endosome to vacuole transport; functional homolog of human obesity receptor gene-related protein (OB-RGRP)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      518763..519185 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181702.3 → NP_012578.3  TPA: Vps55p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012578.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWL5, P47111
      UniProtKB/TrEMBL
      A6ZQ03, B3LQD3, C7GTC4, D3UF93, G2WH48, N1P8P3
      Conserved Domains (1) summary
      pfam04133
      Location:12 → 131
      Vps55; Vacuolar protein sorting 55
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P47111.1

    Gene LinkOut

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