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    Gid8 GID complex subunit 8 [ Mus musculus (house mouse) ]

    Gene ID: 76425, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Gid8provided by MGI
    Official Full Name
    GID complex subunit 8provided by MGI
    Primary source
    MGI:MGI:1923675
    See related
    Ensembl:ENSMUSG00000027573 AllianceGenome:MGI:1923675
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Twa1; 2310003C23Rik; 4833420G11Rik
    Summary
    Enables protein homodimerization activity. Predicted to be involved in positive regulation of canonical Wnt signaling pathway; positive regulation of cell population proliferation; and proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in cell junction; cytosol; and nucleoplasm. Predicted to be part of ubiquitin ligase complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human GID8 (GID complex subunit 8 homolog). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in liver E14 (RPKM 23.4), liver E14.5 (RPKM 22.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gid8 in Genome Data Viewer
    Location:
    2 H4; 2 103.26 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (180351874..180363392)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (180710122..180721599)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene transcription factor-like 5 (basic helix-loop-helix) Neighboring gene predicted gene, 54097 Neighboring gene death inducer-obliterator 1 Neighboring gene STARR-positive B cell enhancer mm9_chr2:180436639-180436940 Neighboring gene STARR-seq mESC enhancer starr_06736 Neighboring gene predicted gene, 22502 Neighboring gene STARR-positive B cell enhancer ABC_E9213 Neighboring gene predicted gene, 30455 Neighboring gene solute carrier family 17, member 9 Neighboring gene STARR-seq mESC enhancer starr_06739 Neighboring gene STARR-positive B cell enhancer ABC_E1614 Neighboring gene basic helix-loop-helix family, member e23

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Studies of recombinant TWA1 reveal constitutive dimerization. Francis O, et al. Biosci Rep, 2017 Feb 28. PMID 27920276, Free PMC Article
    2. A novel nuclear protein, Twa1, and Muskelin comprise a complex with RanBPM. Umeda M, et al. Gene, 2003 Jan 16. PMID 12559565
    3. Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies. Murtaza N, et al. Cell Rep, 2022 Nov 22. PMID 36417873
    4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • RP24-209P15.2

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of canonical Wnt signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell population proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of ubiquitin ligase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    glucose-induced degradation protein 8 homolog
    Names
    GID complex subunit 8 homolog
    protein C20orf11 homolog
    two hybrid-associated protein 1 with RanBPM

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289651.1 → NP_001276580.1  glucose-induced degradation protein 8 homolog

      See identical proteins and their annotated locations for NP_001276580.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AK009106, AL732560
      Consensus CDS
      CCDS17185.1
      UniProtKB/Swiss-Prot
      Q9D7M1
      Conserved Domains (2) summary
      pfam08513
      Location:28 → 52
      LisH
      pfam10607
      Location:63 → 207
      CLTH; CTLH/CRA C-terminal to LisH motif domain

    2. NM_001289652.1 → NP_001276581.1  glucose-induced degradation protein 8 homolog

      See identical proteins and their annotated locations for NP_001276581.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AK009106, AL732560, BY131338
      Consensus CDS
      CCDS17185.1
      UniProtKB/Swiss-Prot
      Q9D7M1
      Related
      ENSMUSP00000029090.3, ENSMUST00000029090.9
      Conserved Domains (2) summary
      pfam08513
      Location:28 → 52
      LisH
      pfam10607
      Location:63 → 207
      CLTH; CTLH/CRA C-terminal to LisH motif domain

    3. NM_029607.2 → NP_083883.1  glucose-induced degradation protein 8 homolog

      See identical proteins and their annotated locations for NP_083883.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AK009106, AL732560, BC059022
      Consensus CDS
      CCDS17185.1
      UniProtKB/Swiss-Prot
      Q9D7M1
      Related
      ENSMUSP00000077753.6, ENSMUST00000078687.6
      Conserved Domains (2) summary
      pfam08513
      Location:28 → 52
      LisH
      pfam10607
      Location:63 → 207
      CLTH; CTLH/CRA C-terminal to LisH motif domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      180351874..180363392
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036162670.1 → XP_036018563.1  glucose-induced degradation protein 8 homolog isoform X2

      Conserved Domains (2) summary
      pfam08513
      Location:28 → 52
      LisH
      pfam10607
      Location:63 → 171
      CLTH; CTLH/CRA C-terminal to LisH motif domain

    2. XM_030252191.2 → XP_030108051.1  glucose-induced degradation protein 8 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q9D7M1
      Conserved Domains (2) summary
      pfam08513
      Location:28 → 52
      LisH
      pfam10607
      Location:63 → 207
      CLTH; CTLH/CRA C-terminal to LisH motif domain

    3. XM_036162669.1 → XP_036018562.1  glucose-induced degradation protein 8 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q9D7M1
      Conserved Domains (2) summary
      pfam08513
      Location:28 → 52
      LisH
      pfam10607
      Location:63 → 207
      CLTH; CTLH/CRA C-terminal to LisH motif domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D7M1.1 GenPept UniProtKB/Swiss-Prot:Q9D7M1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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