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    Tcfl5 transcription factor-like 5 (basic helix-loop-helix) [ Mus musculus (house mouse) ]

    Gene ID: 277353, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Tcfl5provided by MGI
    Official Full Name
    transcription factor-like 5 (basic helix-loop-helix)provided by MGI
    Primary source
    MGI:MGI:2672878
    See related
    Ensembl:ENSMUSG00000038932 AllianceGenome:MGI:2672878
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Figlb; Sosf1
    Summary
    Enables DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Located in male germ cell nucleus. Is expressed in brain and testis. Orthologous to human TCFL5 (transcription factor like 5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward testis adult (RPKM 76.6) See more
    Orthologs
    human all
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    Genomic context

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    See Tcfl5 in Genome Data Viewer
    Location:
    2 H4; 2 103.16 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (180263749..180284540, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (180621956..180642691, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 30144 Neighboring gene STARR-positive B cell enhancer ABC_E4530 Neighboring gene MRG/MORF4L binding protein Neighboring gene opioid growth factor receptor Neighboring gene collagen, type IX, alpha 3 Neighboring gene predicted gene, 54097 Neighboring gene death inducer-obliterator 1 Neighboring gene STARR-positive B cell enhancer mm9_chr2:180436639-180436940 Neighboring gene STARR-seq mESC enhancer starr_06736 Neighboring gene predicted gene, 22502 Neighboring gene GID complex subunit 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The transcription factor TCFL5 responds to A-MYB to elaborate the male meiotic program in mice. Cecchini K, et al. Reproduction, 2023 Feb 1. PMID 36395073, Free PMC Article
    2. Transcription factor-like 5 is a potential DNA- and RNA-binding protein essential for maintaining male fertility in mice. Xu W, et al. J Cell Sci, 2022 Feb 1. PMID 34931239
    3. A-MYB/TCFL5 regulatory architecture ensures the production of pachytene piRNAs in placental mammals. Yu T, et al. RNA, 2022 Oct 14. PMID 36241367, Free PMC Article
    4. TCFL5 deficiency impairs the pachytene to diplotene transition during spermatogenesis in the mouse. Galán-Martínez J, et al. Sci Rep, 2022 Jun 29. PMID 35768632, Free PMC Article
    5. Basic helix-loop-helix transcription factor Tcfl5 interacts with the Calmegin gene promoter in mouse spermatogenesis. Siep M, et al. Nucleic Acids Res, 2004. PMID 15585666, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The transcription factor TCFL5 responds to A-MYB to elaborate the male meiotic program in mice.
      Title: The transcription factor TCFL5 responds to A-MYB to elaborate the male meiotic program in mice.
    2. TCFL5 deficiency impairs the pachytene to diplotene transition during spermatogenesis in the mouse.
      Title: TCFL5 deficiency impairs the pachytene to diplotene transition during spermatogenesis in the mouse.
    3. Transcription factor-like 5 is a potential DNA- and RNA-binding protein essential for maintaining male fertility in mice.
      Title: Transcription factor-like 5 is a potential DNA- and RNA-binding protein essential for maintaining male fertility in mice.
    4. Transcripts highly enriched in ovary; gene identified as candidate female fertility factor.
      Title: Genomewide discovery and classification of candidate ovarian fertility genes in the mouse.
    5. Tcfl5 is a testis-specific transcription factor that interacts with the calmegin gene promoter during spermatogenesis.
      Title: Basic helix-loop-helix transcription factor Tcfl5 interacts with the Calmegin gene promoter in mouse spermatogenesis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC118431

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in male germ cell nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    transcription factor-like 5 protein
    Names
    FIG beta
    factor in the germline beta
    spermatogenesis- and oogenesis-specific bHLH-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360335.2 → NP_001347264.1  transcription factor-like 5 protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL669926, AL732560
      UniProtKB/TrEMBL
      Q810E9

    2. NM_001409509.1 → NP_001396438.1  transcription factor-like 5 protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL669926, AL732560

    3. NM_001409510.1 → NP_001396439.1  transcription factor-like 5 protein isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL669926, AL732560

    4. NM_001409511.1 → NP_001396440.1  transcription factor-like 5 protein isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL669926, AL732560

    5. NM_001409512.1 → NP_001396441.1  transcription factor-like 5 protein isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL669926, AL732560

    6. NM_178254.4 → NP_839985.2  transcription factor-like 5 protein isoform 2

      See identical proteins and their annotated locations for NP_839985.2

      Status: VALIDATED

      Source sequence(s)
      AL669926, AL732560
      Consensus CDS
      CCDS17181.2
      UniProtKB/TrEMBL
      Q32NY8, Q810E9
      Related
      ENSMUSP00000040611.11, ENSMUST00000037877.11

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      180263749..180284540 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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