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    Kcnab2 potassium voltage-gated channel, shaker-related subfamily, beta member 2 [ Mus musculus (house mouse) ]

    Gene ID: 16498, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Kcnab2provided by MGI
    Official Full Name
    potassium voltage-gated channel, shaker-related subfamily, beta member 2provided by MGI
    Primary source
    MGI:MGI:109239
    See related
    Ensembl:ENSMUSG00000028931 AllianceGenome:MGI:109239
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    F5; I2rf5; Kcnb3; kv-beta-2
    Summary
    Predicted to enable aldo-keto reductase (NADPH) activity; potassium channel regulator activity; and transmembrane transporter binding activity. Involved in neuromuscular process. Acts upstream of or within hematopoietic progenitor cell differentiation. Located in axon terminus; juxtaparanode region of axon; and postsynaptic density. Is active in axon initial segment. Is expressed in several structures, including central nervous system; genitourinary system; hemolymphoid system; intestine; and sensory organ. Used to study chromosome 1p36 deletion syndrome. Orthologous to human KCNAB2 (potassium voltage-gated channel subfamily A regulatory beta subunit 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in cortex adult (RPKM 40.8), frontal lobe adult (RPKM 32.0) and 9 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Kcnab2 in Genome Data Viewer
    Location:
    4 E2; 4 83.08 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (152475201..152561991, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (152390744..152477549, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 9430083M05 gene Neighboring gene STARR-positive B cell enhancer ABC_E846 Neighboring gene ribosomal protein L22 Neighboring gene chromodomain helicase DNA binding protein 5 Neighboring gene predicted gene 16333 Neighboring gene nephronophthisis 4 (juvenile) homolog (human) Neighboring gene predicted gene, 30734 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Expression of the T-lymphocyte activation gene, F5, by mature neurons. Arai M, et al. J Neurosci Res, 1992 Dec. PMID 1484386
    2. Characterization of a novel mRNA expressed by neurons in mature brain. Cohen JA, et al. J Neurosci Res, 1992 Feb. PMID 1573677
    3. Deletion of the mouse homolog of KCNAB2, a gene linked to monosomy 1p36, results in associative memory impairments and amygdala hyperexcitability. Perkowski JJ, et al. J Neurosci, 2011 Jan 5. PMID 21209188, Free PMC Article
    4. The potassium channel auxiliary subunit Kvβ2 (Kcnab2) regulates Kv1 channels and dopamine neuron firing. Yee JX, et al. J Neurophysiol, 2022 Jul 1. PMID 35788155, Free PMC Article
    5. Physiological role of Kvβ2 (AKR6) in murine skeletal muscle growth and regulation. Chapalamadugu KC, et al. Acta Physiol (Oxf), 2018 Oct. PMID 29704886, Free PMC Article

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The potassium channel auxiliary subunit Kvbeta2 (Kcnab2) regulates Kv1 channels and dopamine neuron firing.
      Title: The potassium channel auxiliary subunit Kvβ2 (Kcnab2) regulates Kv1 channels and dopamine neuron firing.
    2. Myocardial Blood Flow Control by Oxygen Sensing Vascular Kvbeta Proteins.
      Title: Myocardial Blood Flow Control by Oxygen Sensing Vascular Kvβ Proteins.
    3. Kvbeta2 subunits regulate the expression of myocardial Kv channels and confer redox sensitivity to Kv current and cardiac repolarization.
      Title: Metabolic regulation of Kv channels and cardiac repolarization by Kvβ2 subunits.
    4. Genetic deletion of Kvbeta2 leads to decreased skeletal muscle size along with isotype switching from fast to slow fiber type.
      Title: Physiological role of Kvβ2 (AKR6) in murine skeletal muscle growth and regulation.
    5. Article reports a newly identified protein-protein interaction between the postsynaptic density-protein ProSAP2/Shank3 and the voltage-gated potassium channel subunit Kvbeta2
      Title: The Kvβ2 subunit of voltage-gated potassium channels is interacting with ProSAP2/Shank3 in the PSD.
    6. the association of a Kvbeta subunit with TRPV1 channels, is reported.
      Title: Identification of voltage-gated K(+) channel beta 2 (Kvβ2) subunit as a novel interaction partner of the pain transducer Transient Receptor Potential Vanilloid 1 channel (TRPV1).
    7. This study demonistrated that loss of Kvbeta2 likely contributes to the cognitive and neurological impairments observed in 1p36DS patients.
      Title: Deletion of the mouse homolog of KCNAB2, a gene linked to monosomy 1p36, results in associative memory impairments and amygdala hyperexcitability.
    8. strain differences significantly affected survival, body weight and thermoregulation in Kv beta2-null mice
      Title: Genetic modifiers of the Kv beta2-null phenotype in mice.
    9. investigation of in vivo function
      Title: Genetic analysis of the mammalian K+ channel beta subunit Kvbeta 2 (Kcnab2).
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (2)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables aldo-keto reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aldo-keto reductase (NADPH) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables aldo-keto reductase (NADPH) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables methylglyoxal reductase (NADPH) (acetol producing) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables potassium channel regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables potassium channel regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables potassium channel regulator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transmembrane transporter binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables voltage-gated potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in NADPH oxidation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in NADPH oxidation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within hematopoietic progenitor cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in neuromuscular process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of potassium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of potassium ion transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of protein localization to cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of protein localization to cell surface ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in axon initial segment IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in axon terminus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic side of plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in juxtaparanode region of axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in juxtaparanode region of axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in juxtaparanode region of axon ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    colocalizes_with microtubule ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in neuron projection ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in pinceau fiber ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in pinceau fiber ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynaptic density membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of potassium channel complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of potassium channel complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of voltage-gated potassium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of voltage-gated potassium channel complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    voltage-gated potassium channel subunit beta-2
    Names
    K(+) channel subunit beta-2
    neuroimmune protein F5
    NP_001239583.1
    NP_001239584.1
    NP_001239585.1
    NP_001342101.1
    NP_001342102.1
    NP_001408146.1
    NP_001408147.1
    NP_001408148.1
    NP_001408150.1
    NP_001408151.1
    NP_001408152.1
    NP_001408153.1
    NP_001408154.1
    NP_034728.2
    XP_006538647.1
    XP_006538648.1
    XP_006538649.1
    XP_006538650.1
    XP_011248501.1
    XP_030109127.1
    XP_036019635.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252654.3 → NP_001239583.1  voltage-gated potassium channel subunit beta-2 isoform 2

      See identical proteins and their annotated locations for NP_001239583.1

      Status: VALIDATED

      Source sequence(s)
      AL611985
      Consensus CDS
      CCDS57316.1
      UniProtKB/TrEMBL
      Q3U0B0, Q3UPV6
      Related
      ENSMUSP00000030768.3, ENSMUST00000030768.10
      Conserved Domains (1) summary
      cd19141
      Location:25 → 333
      Aldo_ket_red_shaker; Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR)

    2. NM_001252655.3 → NP_001239584.1  voltage-gated potassium channel subunit beta-2 isoform 2

      See identical proteins and their annotated locations for NP_001239584.1

      Status: VALIDATED

      Source sequence(s)
      AL611985
      Consensus CDS
      CCDS57316.1
      UniProtKB/TrEMBL
      Q3U0B0, Q3UPV6
      Related
      ENSMUSP00000124156.3, ENSMUST00000159840.8
      Conserved Domains (1) summary
      cd19141
      Location:25 → 333
      Aldo_ket_red_shaker; Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR)

    3. NM_001252656.3 → NP_001239585.1  voltage-gated potassium channel subunit beta-2 isoform 1

      See identical proteins and their annotated locations for NP_001239585.1

      Status: VALIDATED

      Source sequence(s)
      AL611985
      Consensus CDS
      CCDS19000.1
      UniProtKB/Swiss-Prot
      P62482, P97381, Q60942, Q64284
      UniProtKB/TrEMBL
      Q3U0B0
      Related
      ENSMUSP00000101273.3, ENSMUST00000105648.10
      Conserved Domains (1) summary
      cd19141
      Location:38 → 347
      Aldo_ket_red_shaker; Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR)

    4. NM_001355172.2 → NP_001342101.1  voltage-gated potassium channel subunit beta-2 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 5 encode the same isoform (1).
      Source sequence(s)
      AL611985
      Consensus CDS
      CCDS19000.1
      UniProtKB/Swiss-Prot
      P62482, P97381, Q60942, Q64284
      UniProtKB/TrEMBL
      Q3U0B0
      Conserved Domains (1) summary
      cd19141
      Location:38 → 347
      Aldo_ket_red_shaker; Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR)

    5. NM_001355173.2 → NP_001342102.1  voltage-gated potassium channel subunit beta-2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL611985
      UniProtKB/TrEMBL
      Q3U0B0
      Related
      ENSMUSP00000158843.2, ENSMUST00000238738.2
      Conserved Domains (1) summary
      cd19141
      Location:38 → 363
      Aldo_ket_red_shaker; Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR)

    6. NM_001421217.1 → NP_001408146.1  voltage-gated potassium channel subunit beta-2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL611985
      UniProtKB/Swiss-Prot
      P62482, P97381, Q60942, Q64284

    7. NM_001421218.1 → NP_001408147.1  voltage-gated potassium channel subunit beta-2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL611985

    8. NM_001421219.1 → NP_001408148.1  voltage-gated potassium channel subunit beta-2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL611985
      Related
      ENSMUSP00000158839.2, ENSMUST00000238715.2

    9. NM_001421221.1 → NP_001408150.1  voltage-gated potassium channel subunit beta-2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL611985

    10. NM_001421222.1 → NP_001408151.1  voltage-gated potassium channel subunit beta-2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL611985

    11. NM_001421223.1 → NP_001408152.1  voltage-gated potassium channel subunit beta-2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL611985
      UniProtKB/TrEMBL
      A0A571BF54
      Related
      ENSMUSP00000158771.2, ENSMUST00000238252.2

    12. NM_001421224.1 → NP_001408153.1  voltage-gated potassium channel subunit beta-2 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL611985

    13. NM_001421225.1 → NP_001408154.1  voltage-gated potassium channel subunit beta-2 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AL611985
      UniProtKB/TrEMBL
      E0CXZ9
      Related
      ENSMUSP00000124588.3, ENSMUST00000159186.9

    14. NM_010598.5 → NP_034728.2  voltage-gated potassium channel subunit beta-2 isoform 1

      See identical proteins and their annotated locations for NP_034728.2

      Status: VALIDATED

      Source sequence(s)
      AL611985
      Consensus CDS
      CCDS19000.1
      UniProtKB/Swiss-Prot
      P62482, P97381, Q60942, Q64284
      UniProtKB/TrEMBL
      Q3U0B0
      Related
      ENSMUSP00000125058.2, ENSMUST00000160884.9
      Conserved Domains (1) summary
      cd19141
      Location:38 → 347
      Aldo_ket_red_shaker; Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      152475201..152561991 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011250199.3 → XP_011248501.1  voltage-gated potassium channel subunit beta-2 isoform X3

      See identical proteins and their annotated locations for XP_011248501.1

      UniProtKB/TrEMBL
      Q3U0B0
      Conserved Domains (1) summary
      cd19141
      Location:38 → 363
      Aldo_ket_red_shaker; Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR)

    2. XM_006538586.4 → XP_006538649.1  voltage-gated potassium channel subunit beta-2 isoform X4

      See identical proteins and their annotated locations for XP_006538649.1

      UniProtKB/TrEMBL
      Q3U0B0
      Conserved Domains (1) summary
      cd19141
      Location:25 → 349
      Aldo_ket_red_shaker; Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR)

    3. XM_030253267.1 → XP_030109127.1  voltage-gated potassium channel subunit beta-2 isoform X5

      UniProtKB/Swiss-Prot
      P62482, P97381, Q60942, Q64284
      UniProtKB/TrEMBL
      Q3U0B0
      Conserved Domains (1) summary
      cd19141
      Location:38 → 347
      Aldo_ket_red_shaker; Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR)

    4. XM_006538585.4 → XP_006538648.1  voltage-gated potassium channel subunit beta-2 isoform X3

      See identical proteins and their annotated locations for XP_006538648.1

      UniProtKB/TrEMBL
      Q3U0B0
      Conserved Domains (1) summary
      cd19141
      Location:38 → 363
      Aldo_ket_red_shaker; Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR)

    5. XM_006538584.5 → XP_006538647.1  voltage-gated potassium channel subunit beta-2 isoform X3

      See identical proteins and their annotated locations for XP_006538647.1

      UniProtKB/TrEMBL
      Q3U0B0
      Conserved Domains (1) summary
      cd19141
      Location:38 → 363
      Aldo_ket_red_shaker; Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR)

    6. XM_006538587.5 → XP_006538650.1  voltage-gated potassium channel subunit beta-2 isoform X4

      See identical proteins and their annotated locations for XP_006538650.1

      UniProtKB/TrEMBL
      Q3U0B0
      Conserved Domains (1) summary
      cd19141
      Location:25 → 349
      Aldo_ket_red_shaker; Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR)

    7. XM_036163742.1 → XP_036019635.1  voltage-gated potassium channel subunit beta-2 isoform X3

      UniProtKB/TrEMBL
      Q3U0B0
      Conserved Domains (1) summary
      cd19141
      Location:38 → 363
      Aldo_ket_red_shaker; Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P62482.1 GenPept UniProtKB/Swiss-Prot:P62482

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