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    Dtnb dystrobrevin, beta [ Mus musculus (house mouse) ]

    Gene ID: 13528, updated on 3-Dec-2024

    Summary

    Official Symbol
    Dtnbprovided by MGI
    Official Full Name
    dystrobrevin, betaprovided by MGI
    Primary source
    MGI:MGI:1203728
    See related
    Ensembl:ENSMUSG00000071454 AllianceGenome:MGI:1203728
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables DNA binding activity. Predicted to be involved in neuron differentiation and synaptic signaling. Located in cytoplasm; inhibitory synapse; and nucleus. Is active in GABA-ergic synapse and postsynapse. Orthologous to human DTNB (dystrobrevin beta). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 19.5), frontal lobe adult (RPKM 9.3) and 27 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Dtnb in Genome Data Viewer
    Location:
    12 A1.1; 12 1.88 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (3622372..3834070)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (3572372..3785486)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31332 Neighboring gene ASXL transcriptional regulator 2 Neighboring gene STARR-seq mESC enhancer starr_31410 Neighboring gene STARR-seq mESC enhancer starr_31411 Neighboring gene STARR-seq mESC enhancer starr_31412 Neighboring gene STARR-seq mESC enhancer starr_31413 Neighboring gene ribosomal protein S7, pseudogene 2 Neighboring gene STARR-seq mESC enhancer starr_31417 Neighboring gene 40S ribosomal protein S26-like Neighboring gene STARR-seq mESC enhancer starr_31419 Neighboring gene predicted gene, 50591 Neighboring gene STARR-seq mESC enhancer starr_31422 Neighboring gene predicted gene, 53748 Neighboring gene STARR-seq mESC enhancer starr_31423 Neighboring gene STARR-seq mESC enhancer starr_31424 Neighboring gene STARR-positive B cell enhancer ABC_E3047 Neighboring gene predicted gene, 18028 Neighboring gene STARR-seq mESC enhancer starr_31427 Neighboring gene DNA methyltransferase 3A Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:3855747-3855931 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:3870938-3871047 Neighboring gene DNA methyltransferase 3A, opposite strand Neighboring gene STARR-seq mESC enhancer starr_31429 Neighboring gene predicted gene, 31623

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in synaptic signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in GABA-ergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in basal plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    located_in inhibitory synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in postsynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynaptic density ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    dystrobrevin beta
    Names
    DTN-B
    beta-dystrobrevin
    mDTN-B
    mDTN-BDTN-B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001162465.3NP_001155937.1  dystrobrevin beta isoform a

      See identical proteins and their annotated locations for NP_001155937.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      AC155273, CR974568
      Consensus CDS
      CCDS49015.1
      UniProtKB/Swiss-Prot
      E9Q0F2, O70563, O70585, Q9CTZ1
      UniProtKB/TrEMBL
      G3UYM7
      Related
      ENSMUSP00000126194.3, ENSMUST00000164578.9
      Conserved Domains (4) summary
      cd02334
      Location:241289
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      pfam09068
      Location:16140
      EF-hand_2; EF hand
      pfam09069
      Location:144232
      EF-hand_3; EF-hand
      cl23720
      Location:442522
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    2. NM_001355528.2NP_001342457.1  dystrobrevin beta isoform c

      Status: VALIDATED

      Source sequence(s)
      AC155273, CR974568
      UniProtKB/TrEMBL
      G3UXK0
      Related
      ENSMUSP00000133722.2, ENSMUST00000173240.8
      Conserved Domains (3) summary
      COG1196
      Location:407497
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd02334
      Location:241289
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      cd16244
      Location:54214
      EFh_DTN; EF-hand-like motif found in dystrobrevins and similar proteins
    3. NM_001374710.2NP_001361639.1  dystrobrevin beta isoform d

      Status: VALIDATED

      Source sequence(s)
      AC155273, CR974568
      Consensus CDS
      CCDS88301.1
      UniProtKB/TrEMBL
      G3UZ87, Q8C8Z9
      Related
      ENSMUSP00000134392.2, ENSMUST00000173199.8
      Conserved Domains (3) summary
      COG1196
      Location:437527
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd02334
      Location:241289
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      cd16244
      Location:54214
      EFh_DTN; EF-hand-like motif found in dystrobrevins and similar proteins
    4. NM_001421902.1NP_001408831.1  dystrobrevin beta isoform c

      Status: VALIDATED

      Source sequence(s)
      AC155273, CR974568
      UniProtKB/TrEMBL
      G3UXK0
    5. NM_007886.3NP_031912.2  dystrobrevin beta isoform b

      See identical proteins and their annotated locations for NP_031912.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and contains an alternate exon in the 3' coding region, which results in a frameshift and an early stop codon compared to variant 1. The encoded isoform (b) is shorter and has a distinct C-terminus compared to isoform a.
      Source sequence(s)
      AC155273, AK043436, CR974568
      Consensus CDS
      CCDS36396.2
      UniProtKB/TrEMBL
      Q8C8Z9, Q8K0N0
      Related
      ENSMUSP00000077085.7, ENSMUST00000077930.13
      Conserved Domains (4) summary
      PRK00286
      Location:355526
      xseA; exodeoxyribonuclease VII large subunit; Reviewed
      PRK05431
      Location:440510
      PRK05431; seryl-tRNA synthetase; Provisional
      cd02334
      Location:241289
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      cd16244
      Location:54214
      EFh_DTN; EF-hand-like motif found in dystrobrevins and similar proteins

    RNA

    1. NR_027869.3 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains three alternate internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC155273, CR974568
    2. NR_027870.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains two alternate internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC155273, AK043436, CR974568
    3. NR_149729.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC155273, CR974568

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      3622372..3834070
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017314952.3XP_017170441.1  dystrobrevin beta isoform X2

      UniProtKB/TrEMBL
      G3UXK0
      Conserved Domains (3) summary
      COG1196
      Location:407497
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd02334
      Location:241289
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      cd16244
      Location:54214
      EFh_DTN; EF-hand-like motif found in dystrobrevins and similar proteins
    2. XM_030246547.2XP_030102407.1  dystrobrevin beta isoform X7

      UniProtKB/TrEMBL
      Q8C8Z9
      Conserved Domains (3) summary
      COG1196
      Location:407497
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd02334
      Location:241289
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      cd16244
      Location:54214
      EFh_DTN; EF-hand-like motif found in dystrobrevins and similar proteins
    3. XM_017314955.2XP_017170444.1  dystrobrevin beta isoform X12

      UniProtKB/TrEMBL
      G3UXK0
      Conserved Domains (3) summary
      COG1196
      Location:407497
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd02334
      Location:241289
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      cd16244
      Location:54214
      EFh_DTN; EF-hand-like motif found in dystrobrevins and similar proteins
    4. XM_017314953.3XP_017170442.1  dystrobrevin beta isoform X3

      UniProtKB/TrEMBL
      Q8C8Z9
      Conserved Domains (3) summary
      COG1340
      Location:404485
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      cd02334
      Location:241289
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      cd16244
      Location:54214
      EFh_DTN; EF-hand-like motif found in dystrobrevins and similar proteins
    5. XM_036157176.1XP_036013069.1  dystrobrevin beta isoform X10

      UniProtKB/TrEMBL
      Q8C8Z9
      Conserved Domains (3) summary
      COG1340
      Location:404485
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      cd02334
      Location:241289
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      cd16244
      Location:54214
      EFh_DTN; EF-hand-like motif found in dystrobrevins and similar proteins
    6. XM_011243813.4XP_011242115.1  dystrobrevin beta isoform X1

      UniProtKB/TrEMBL
      Q8C8Z9
      Conserved Domains (3) summary
      COG1196
      Location:437527
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd02334
      Location:241289
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      cd16244
      Location:54214
      EFh_DTN; EF-hand-like motif found in dystrobrevins and similar proteins
    7. XM_011243814.4XP_011242116.1  dystrobrevin beta isoform X5

      UniProtKB/TrEMBL
      Q8C8Z9
      Conserved Domains (4) summary
      COG1340
      Location:434515
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      PRK00286
      Location:355526
      xseA; exodeoxyribonuclease VII large subunit; Reviewed
      cd02334
      Location:241289
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      cd16244
      Location:54214
      EFh_DTN; EF-hand-like motif found in dystrobrevins and similar proteins
    8. XM_006514960.5XP_006515023.1  dystrobrevin beta isoform X6

      UniProtKB/TrEMBL
      G3UY34
      Conserved Domains (3) summary
      COG1196
      Location:437527
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd02334
      Location:241289
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      cd16244
      Location:54214
      EFh_DTN; EF-hand-like motif found in dystrobrevins and similar proteins
    9. XM_006514961.5XP_006515024.1  dystrobrevin beta isoform X8

      UniProtKB/TrEMBL
      G3UY34
      Related
      ENSMUSP00000133927.2, ENSMUST00000174547.8
      Conserved Domains (3) summary
      COG1196
      Location:437527
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd02334
      Location:241289
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      cd16244
      Location:54214
      EFh_DTN; EF-hand-like motif found in dystrobrevins and similar proteins
    10. XM_006514959.5XP_006515022.1  dystrobrevin beta isoform X4

      See identical proteins and their annotated locations for XP_006515022.1

      UniProtKB/TrEMBL
      Q8C8Z9, Q8K0N0
      Related
      ENSMUSP00000128230.3, ENSMUST00000164607.9
      Conserved Domains (4) summary
      PRK00286
      Location:355526
      xseA; exodeoxyribonuclease VII large subunit; Reviewed
      PRK05431
      Location:440510
      PRK05431; seryl-tRNA synthetase; Provisional
      cd02334
      Location:241289
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      cd16244
      Location:54214
      EFh_DTN; EF-hand-like motif found in dystrobrevins and similar proteins
    11. XM_017314954.3XP_017170443.1  dystrobrevin beta isoform X9

      UniProtKB/TrEMBL
      G3UY34
      Conserved Domains (4) summary
      COG1340
      Location:434515
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      PRK00286
      Location:355526
      xseA; exodeoxyribonuclease VII large subunit; Reviewed
      cd02334
      Location:241289
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      cd16244
      Location:54214
      EFh_DTN; EF-hand-like motif found in dystrobrevins and similar proteins
    12. XM_030246548.2XP_030102408.1  dystrobrevin beta isoform X11

      UniProtKB/TrEMBL
      G3UY34
      Conserved Domains (4) summary
      PRK00286
      Location:355526
      xseA; exodeoxyribonuclease VII large subunit; Reviewed
      PRK05431
      Location:440510
      PRK05431; seryl-tRNA synthetase; Provisional
      cd02334
      Location:241289
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      cd16244
      Location:54214
      EFh_DTN; EF-hand-like motif found in dystrobrevins and similar proteins
    13. XM_036157183.1XP_036013076.1  dystrobrevin beta isoform X19

      Conserved Domains (2) summary
      COG1196
      Location:157247
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd02334
      Location:139
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    14. XM_036157182.1XP_036013075.1  dystrobrevin beta isoform X19

      Conserved Domains (2) summary
      COG1196
      Location:157247
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd02334
      Location:139
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    15. XM_030246553.2XP_030102413.1  dystrobrevin beta isoform X15

      Conserved Domains (4) summary
      COG1196
      Location:253343
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd02334
      Location:87135
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      cd15901
      Location:3760
      EFh_DMD_DYTN_DTN; EF-hand-like motif [structural motif]
      cl07621
      Location:160
      EFh_DMD_DYTN_DTN; EF-hand-like motif found in the dystrophin/dystrobrevin/dystrotelin family
    16. XM_036157179.1XP_036013072.1  dystrobrevin beta isoform X16

      Conserved Domains (3) summary
      COG1196
      Location:253343
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd02334
      Location:87135
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      pfam09069
      Location:178
      EF-hand_3
    17. XM_017314951.3XP_017170440.1  dystrobrevin beta isoform X1

      UniProtKB/TrEMBL
      Q8C8Z9
      Conserved Domains (3) summary
      COG1196
      Location:437527
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd02334
      Location:241289
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      cd16244
      Location:54214
      EFh_DTN; EF-hand-like motif found in dystrobrevins and similar proteins
    18. XM_036157175.1XP_036013068.1  dystrobrevin beta isoform X9

      UniProtKB/TrEMBL
      G3UY34
      Conserved Domains (4) summary
      COG1340
      Location:434515
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      PRK00286
      Location:355526
      xseA; exodeoxyribonuclease VII large subunit; Reviewed
      cd02334
      Location:241289
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      cd16244
      Location:54214
      EFh_DTN; EF-hand-like motif found in dystrobrevins and similar proteins
    19. XM_036157181.1XP_036013074.1  dystrobrevin beta isoform X18

      Conserved Domains (3) summary
      COG1340
      Location:184265
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      PRK00286
      Location:105276
      xseA; exodeoxyribonuclease VII large subunit; Reviewed
      cl00295
      Location:139
      ZZ; Zinc finger, ZZ type. Zinc finger present in dystrophin, CBP/p300 and many other proteins. The ZZ motif coordinates one or two zinc ions and most likely participates in ligand binding or molecular scaffolding. Many proteins containing ZZ motifs have ...
    20. XM_030246551.2XP_030102411.1  dystrobrevin beta isoform X14

      UniProtKB/TrEMBL
      G3UYK9
      Conserved Domains (4) summary
      COG1196
      Location:283373
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd02334
      Location:87135
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      cd15901
      Location:3760
      EFh_DMD_DYTN_DTN; EF-hand-like motif [structural motif]
      cl07621
      Location:160
      EFh_DMD_DYTN_DTN; EF-hand-like motif found in the dystrophin/dystrobrevin/dystrotelin family
    21. XM_036157180.1XP_036013073.1  dystrobrevin beta isoform X17

      Conserved Domains (2) summary
      COG1196
      Location:187277
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cl00295
      Location:139
      ZZ; Zinc finger, ZZ type. Zinc finger present in dystrophin, CBP/p300 and many other proteins. The ZZ motif coordinates one or two zinc ions and most likely participates in ligand binding or molecular scaffolding. Many proteins containing ZZ motifs have ...
    22. XM_030246545.2XP_030102405.1  dystrobrevin beta isoform X2

      UniProtKB/TrEMBL
      G3UXK0
      Conserved Domains (3) summary
      COG1196
      Location:407497
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd02334
      Location:241289
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      cd16244
      Location:54214
      EFh_DTN; EF-hand-like motif found in dystrobrevins and similar proteins
    23. XM_030246544.2XP_030102404.1  dystrobrevin beta isoform X1

      UniProtKB/TrEMBL
      Q8C8Z9
      Conserved Domains (3) summary
      COG1196
      Location:437527
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd02334
      Location:241289
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      cd16244
      Location:54214
      EFh_DTN; EF-hand-like motif found in dystrobrevins and similar proteins