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    TOS1 Tos1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852459, updated on 9-Dec-2024

    Summary

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    Official Symbol
    TOS1
    Official Full Name
    Tos1p
    Primary source
    SGD:S000000366
    Locus tag
    YBR162C
    See related
    AllianceGenome:SGD:S000000366; FungiDB:YBR162C; VEuPathDB:YBR162C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable hydrolase activity, acting on glycosyl bonds. Predicted to be involved in cell wall organization. Located in fungal-type cell wall. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See TOS1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (563203..564570, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene cyclin-dependent serine/threonine-protein kinase CDC28 Neighboring gene mannosylinositol phosphorylceramide synthase catalytic subunit CSH1 Neighboring gene Ysy6p Neighboring gene Exo5p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. TOS1 is circularly permuted 1,3-beta-glucanase. Steczkiewicz K, et al. Cell Cycle, 2010 Jan 1. PMID 20016268
    2. Sequence analysis of a 5.6 kb fragment of chromosome II from Saccharomyces cerevisiae reveals two new open reading frames next to CDC28. Baur S, et al. Yeast, 1995 Apr 30. PMID 7597849
    3. Genomic binding sites of the yeast cell-cycle transcription factors SBF and MBF. Iyer VR, et al. Nature, 2001 Jan 25. PMID 11206552
    4. Identification of a complex genetic network underlying Saccharomyces cerevisiae colony morphology. Voordeckers K, et al. Mol Microbiol, 2012 Oct. PMID 22882838, Free PMC Article
    5. Analysis of congenital disorder of glycosylation-Id in a yeast model system shows diverse site-specific under-glycosylation of glycoproteins. Bailey UM, et al. J Proteome Res, 2012 Nov 2. PMID 23038983

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables hydrolase activity, acting on glycosyl bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cell wall organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in fungal-type cell wall IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in fungal-type cell wall IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in fungal-type vacuole HDA PubMed 

    General protein information

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    Preferred Names
    Tos1p
    NP_009720.1
    • Covalently-bound cell wall hypothetical protein; identified as a cell cycle regulated SBF target gene; deletion mutants are highly resistant to treatment with beta-1,3-glucanase; has sequence similarity to YJL171C

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      563203..564570 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178510.1 → NP_009720.1  TPA: Tos1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009720.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQF7, P38288
      UniProtKB/TrEMBL
      A6ZLA4, B3LMZ7, B5VEB8, G2W9G4, N1P8K5
      Conserved Domains (2) summary
      pfam10287
      Location:223 → 441
      DUF2401; Putative TOS1-like glycosyl hydrolase (DUF2401)
      pfam10290
      Location:39 → 97
      DUF2403; Glycine-rich protein domain (DUF2403)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38288.1

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