Fscn1 fascin actin-bundling protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fscn1provided by MGI
Official Full Name: fascin actin-bundling protein 1provided by MGI
Primary source: MGI:MGI:1352745
See related: Ensembl:ENSMUSG00000029581 AllianceGenome:MGI:1352745
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fan1; fascin-1
Summary: Enables actin filament binding activity. Involved in cell migration and positive regulation of filopodium assembly. Acts upstream of or within actin filament bundle assembly. Located in filopodium; growth cone; and lamellipodium. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Orthologous to human FSCN1 (fascin actin-bundling protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in whole brain E14.5 (RPKM 192.6), CNS E14 (RPKM 164.7) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 G2; 5 81.84 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (142946110..142958944)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (142960355..142973189)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SirT7-mediated transcription of fascin in hyperglycemic glomerular endothelial cells contributes to EndMT in diabetic nephropathy.
Title: SirT7-mediated transcription of fascin in hyperglycemic glomerular endothelial cells contributes to EndMT in diabetic nephropathy.
Fascin-1 limits myosin activity in microglia to control mechanical characterization of the injured spinal cord.
Title: Fascin-1 limits myosin activity in microglia to control mechanical characterization of the injured spinal cord.
GRHL3 activates FSCN1 to relax cell-cell adhesions between migrating keratinocytes during wound reepithelialization.
Title: GRHL3 activates FSCN1 to relax cell-cell adhesions between migrating keratinocytes during wound reepithelialization.
Preventing alloimmune rejection using circular RNA FSCN1-silenced dendritic cells in heart transplantation.
Title: Preventing alloimmune rejection using circular RNA FSCN1-silenced dendritic cells in heart transplantation.
BP-1-102 and silencing of Fascin-1 by RNA interference inhibits the proliferation of mouse pituitary adenoma AtT20 cells via the signal transducer and activator of transcription 3/fascin-1 pathway.
Title: BP-1-102 and silencing of Fascin-1 by RNA interference inhibits the proliferation of mouse pituitary adenoma AtT20 cells via the signal transducer and activator of transcription 3/fascin-1 pathway.
FASCIN regulates actin assembly for spindle movement and polar body extrusion in mouse oocyte meiosis.
Title: FASCIN regulates actin assembly for spindle movement and polar body extrusion in mouse oocyte meiosis.
Investigation of Fascin1, a Marker of Mature Dendritic Cells, Reveals a New Role for IL-6 Signaling in CCR7-Mediated Chemotaxis.
Title: Investigation of Fascin1, a Marker of Mature Dendritic Cells, Reveals a New Role for IL-6 Signaling in CCR7-Mediated Chemotaxis.
A function of fascin1 in the colony formation of mouse embryonic stem cells.
Title: A function of fascin1 in the colony formation of mouse embryonic stem cells.
Our study is the first to show that fascin-1 plays a critical role in renal fibrosis; MiR-200b/c family could inhibit renal fibrosis through modulating EMT process by directly targeting fascin-1/CD44 axis
Title: MiR-200b/c family inhibits renal fibrosis through modulating epithelial-to-mesenchymal transition via targeting fascin-1/CD44 axis.
Fascin-1 is specifically expressed in podocytes.
Title: Studying the role of fascin-1 in mechanically stressed podocytes.

Submit: New GeneRIF Correction See all GeneRIFs (26)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Gene trapped (1) 1 citation
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH136198 (e-PCR)
- UniSTS:210193

L33726 (e-PCR)
- UniSTS:163379

Fscn1 (e-PCR), detects polymorphism
- UniSTS:143069

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables actin binding	ISO Inferred from Sequence Orthology more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	IDA Inferred from Direct Assay more info	PubMed
enables actin filament binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables actin filament binding	ISO Inferred from Sequence Orthology more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-macromolecule adaptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in actin filament bundle assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within actin filament bundle assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in actin filament bundle assembly	ISO Inferred from Sequence Orthology more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell migration	ISO Inferred from Sequence Orthology more info
involved_in cell motility	ISO Inferred from Sequence Orthology more info
involved_in cell motility	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell-cell junction assembly	ISO Inferred from Sequence Orthology more info
involved_in cell-cell junction assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in establishment of apical/basal cell polarity	ISO Inferred from Sequence Orthology more info
involved_in establishment of apical/basal cell polarity	ISS Inferred from Sequence or Structural Similarity more info
involved_in establishment or maintenance of cell polarity	IBA Inferred from Biological aspect of Ancestor more info
involved_in microspike assembly	ISO Inferred from Sequence Orthology more info
involved_in microspike assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in parallel actin filament bundle assembly	IEA Inferred from Electronic Annotation more info
involved_in parallel actin filament bundle assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of extracellular matrix disassembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of extracellular matrix disassembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of filopodium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of filopodium assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of filopodium assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of lamellipodium assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of lamellipodium assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of podosome assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of podosome assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of actin cytoskeleton organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of microvillus assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of microvillus assembly	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in actin cytoskeleton	ISS Inferred from Sequence or Structural Similarity more info
located_in cell cortex	IEA Inferred from Electronic Annotation more info
is_active_in cell projection membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in cell projection membrane	ISO Inferred from Sequence Orthology more info
located_in cell projection membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
is_active_in filopodium	IBA Inferred from Biological aspect of Ancestor more info
located_in filopodium	IDA Inferred from Direct Assay more info	PubMed
located_in filopodium	ISO Inferred from Sequence Orthology more info
is_active_in growth cone	IBA Inferred from Biological aspect of Ancestor more info
located_in growth cone	IDA Inferred from Direct Assay more info	PubMed
located_in growth cone	ISO Inferred from Sequence Orthology more info
is_active_in lamellipodium	IBA Inferred from Biological aspect of Ancestor more info
located_in lamellipodium	IDA Inferred from Direct Assay more info	PubMed
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in microspike	ISO Inferred from Sequence Orthology more info
located_in microspike	ISS Inferred from Sequence or Structural Similarity more info
is_active_in microvillus	IBA Inferred from Biological aspect of Ancestor more info
located_in microvillus	ISO Inferred from Sequence Orthology more info
located_in microvillus	ISS Inferred from Sequence or Structural Similarity more info
located_in myelin sheath	HDA more info	PubMed
located_in podosome	ISO Inferred from Sequence Orthology more info
located_in podosome	ISS Inferred from Sequence or Structural Similarity more info
is_active_in ruffle	IBA Inferred from Biological aspect of Ancestor more info
located_in ruffle	ISO Inferred from Sequence Orthology more info
located_in ruffle	ISS Inferred from Sequence or Structural Similarity more info
located_in stress fiber	ISO Inferred from Sequence Orthology more info
located_in stress fiber	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: fascin

Names: fascin 1; singed-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007984.2 → NP_032010.2 fascin

See identical proteins and their annotated locations for NP_032010.2

Status: VALIDATED

Source sequence(s)

BC052408, BY311024, CJ286472

Consensus CDS

CCDS19834.1

UniProtKB/Swiss-Prot

O09099, O09156, Q05DK3, Q61553, Q7TN32, Q80V75

Related

ENSMUSP00000031565.9, ENSMUST00000031565.15

Conserved Domains (2) summary

cd00257
Location:383 → 493

Fascin; Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an ...

pfam06268
Location:268 → 378

Fascin; Fascin domain