Rnd3 Rho family GTPase 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rnd3provided by MGI
Official Full Name: Rho family GTPase 3provided by MGI
Primary source: MGI:MGI:1921444
See related: Ensembl:ENSMUSG00000017144 AllianceGenome:MGI:1921444
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Arhe; Rhoe; 2610017M01Rik
Summary: Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Predicted to be involved in several processes, including actin filament organization; regulation of actin cytoskeleton organization; and signal transduction. Predicted to be located in Golgi membrane. Predicted to be active in cytosol and plasma membrane. Is expressed in several structures, including cardiovascular system; central nervous system; genitourinary system; liver; and retina. Orthologous to human RND3 (Rho family GTPase 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in CNS E11.5 (RPKM 46.9), whole brain E14.5 (RPKM 28.6) and 11 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 C1.1; 2 29.63 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (51020451..51039123, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (51130439..51149111, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RND3 modulates microglial polarization and alleviates neuroinflammation in Parkinson's disease by suppressing NLRP3 inflammasome activation.
Title: RND3 modulates microglial polarization and alleviates neuroinflammation in Parkinson's disease by suppressing NLRP3 inflammasome activation.
Identification of New Markers of Angiogenic Sprouting Using Transcriptomics: New Role for RND3.
Title: Identification of New Markers of Angiogenic Sprouting Using Transcriptomics: New Role for RND3.
Rnd3 suppresses endothelial cell pyroptosis in atherosclerosis through regulation of ubiquitination of TRAF6.
Title: Rnd3 suppresses endothelial cell pyroptosis in atherosclerosis through regulation of ubiquitination of TRAF6.
Fibroblast-specific activation of Rnd3 protects against cardiac remodeling in diabetic cardiomyopathy via suppression of Notch and TGF-beta signaling.
Title: Fibroblast-specific activation of Rnd3 protects against cardiac remodeling in diabetic cardiomyopathy via suppression of Notch and TGF-β signaling.
Rnd3 is necessary for the correct oligodendrocyte differentiation and myelination in the central nervous system.
Title: Rnd3 is necessary for the correct oligodendrocyte differentiation and myelination in the central nervous system.
Genetic deletion of Rnd3 suppresses apoptosis through NFkappaB signaling in the brain.
Title: Genetic deletion of Rnd3 suppresses apoptosis through NF‑κB signaling in the brain.
Genetic ablation of the Rho GTPase Rnd3 triggers developmental defects in internal capsule and the globus pallidus formation.
Title: Genetic ablation of the Rho GTPase Rnd3 triggers developmental defects in internal capsule and the globus pallidus formation.
The study uncovers RhoE as a new fine-tuning factor modulating myocardial infarction-induced inflammation and promoting injured heart recovery.
Title: RhoE Fine-Tunes Inflammatory Response in Myocardial Infarction.
This study demonstrated that Rnd3 is a key molecule to acquire a neuroprotective phenotype in microglia.
Title: The atypical RhoGTPase RhoE/Rnd3 is a key molecule to acquire a neuroprotective phenotype in microglia.
Rnd3 acted as a novel proangiogenic factor involved in cardiac responsive angiogenesis through HIF1alpha-VEGFA signaling promotion.
Title: Rnd3/RhoE Modulates Hypoxia-Inducible Factor 1α/Vascular Endothelial Growth Factor Signaling by Stabilizing Hypoxia-Inducible Factor 1α and Regulates Responsive Cardiac Angiogenesis.

Submit: New GeneRIF Correction See all GeneRIFs (25)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation
Gene trapped (2) 1 citation
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH140139 (e-PCR)
- UniSTS:222218

AI661404 (e-PCR)
- UniSTS:164161

RH143020 (e-PCR)
- UniSTS:232267

NoName (e-PCR)
- UniSTS:234388

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in small GTPase-mediated signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: rho-related GTP-binding protein RhoE

Names: ras homolog gene family, member E

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.