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    PARPBP PARP1 binding protein [ Homo sapiens (human) ]

    Gene ID: 55010, updated on 27-Nov-2024

    Summary

    Official Symbol
    PARPBPprovided by HGNC
    Official Full Name
    PARP1 binding proteinprovided by HGNC
    Primary source
    HGNC:HGNC:26074
    See related
    Ensembl:ENSG00000185480 MIM:613687; AllianceGenome:HGNC:26074
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AROM; PARI; C12orf48
    Summary
    Predicted to enable DNA binding activity. Involved in negative regulation of double-strand break repair via homologous recombination. Located in chromatin and nucleoplasm. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in bone marrow (RPKM 2.3), testis (RPKM 1.7) and 22 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See PARPBP in Genome Data Viewer
    Location:
    12q23.2
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (102120183..102197520)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (102081315..102158656)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (102513961..102591298)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene WASH complex subunit 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6877 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6878 Neighboring gene nucleoporin 37 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6879 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:102514807-102515364 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:102546739-102547240 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6880 Neighboring gene uncharacterized LOC124902998 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_22888 Neighboring gene pro-melanin concentrating hormone Neighboring gene RNA, 7SL, cytoplasmic 793, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ20641

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001319988.2NP_001306917.1  PCNA-interacting partner isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC079907, AC087882
      Consensus CDS
      CCDS81728.1
      UniProtKB/TrEMBL
      B4DZ31
      Related
      ENSP00000440850.1, ENST00000541394.5
      Conserved Domains (1) summary
      TIGR01074
      Location:249393
      rep; ATP-dependent DNA helicase Rep
    2. NM_001319993.2NP_001306922.1  PCNA-interacting partner isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate exon and lacks an exon in the 5' region, and initiates translation at downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus and is shorter than isoform 1. Variants 3 and 4 encode the same isoform (3).
      Source sequence(s)
      AC079907, AC087882
      Consensus CDS
      CCDS81730.1
      Conserved Domains (1) summary
      TIGR01074
      Location:91235
      rep; ATP-dependent DNA helicase Rep
    3. NM_001319994.2NP_001306923.1  PCNA-interacting partner isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate splice site and lacks an exon in the 5' region, and initiates translation at downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus and is shorter than isoform 1. Variants 3 and 4 encode the same isoform (3).
      Source sequence(s)
      AC079907, AC087882
      Consensus CDS
      CCDS81730.1
      Related
      ENSP00000376643.2, ENST00000392911.6
      Conserved Domains (1) summary
      TIGR01074
      Location:91235
      rep; ATP-dependent DNA helicase Rep
    4. NM_001319995.3NP_001306924.1  PCNA-interacting partner isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) contains an alternate exon and lacks an exon in the 5' region, lacks multiple 3' coding exons, and contains an alternate 3' coding region and 3' UTR, compared to variant 1. It initiates translation at a downstream start codon. The encoded isoform (4) has a shorter N-terminus and a distinct C-terminus, and is shorter than isoform 1.
      Source sequence(s)
      AC087882, AF274940, BC070270, CA415422, DB260405
      UniProtKB/Swiss-Prot
      Q9NWS1
      UniProtKB/TrEMBL
      Q9BZU5
      Conserved Domains (1) summary
      TIGR01074
      Location:91140
      rep; ATP-dependent DNA helicase Rep
    5. NM_001319996.2NP_001306925.1  PCNA-interacting partner isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) lacks multiple 3' coding exons and differs in the 3' coding region and 3' UTR compared to variant 1. The encoded isoform (5) has a shorter, distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC079907, AC087882
      Consensus CDS
      CCDS81729.1
      UniProtKB/TrEMBL
      G8JLI2
      Related
      ENSP00000442549.1, ENST00000537257.5
    6. NM_001382721.1NP_001369650.1  PCNA-interacting partner isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882
    7. NM_001382722.1NP_001369651.1  PCNA-interacting partner isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882
    8. NM_001382723.1NP_001369652.1  PCNA-interacting partner isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882
    9. NM_001382724.1NP_001369653.1  PCNA-interacting partner isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882
    10. NM_001382725.1NP_001369654.1  PCNA-interacting partner isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882
    11. NM_001382726.1NP_001369655.1  PCNA-interacting partner isoform 11

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882
    12. NM_001382728.1NP_001369657.1  PCNA-interacting partner isoform 12

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882
    13. NM_001382729.1NP_001369658.1  PCNA-interacting partner isoform 13

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882
    14. NM_001382731.1NP_001369660.1  PCNA-interacting partner isoform 14

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882
      UniProtKB/TrEMBL
      J3KQY3
      Related
      ENSP00000411313.2, ENST00000417507.6
    15. NM_001382732.1NP_001369661.1  PCNA-interacting partner isoform 15

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882
      UniProtKB/TrEMBL
      A0A0C4DG30
      Related
      ENSP00000393867.2, ENST00000412715.3
    16. NM_001382735.1NP_001369664.1  PCNA-interacting partner isoform 16

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882
      Consensus CDS
      CCDS91743.1
      UniProtKB/TrEMBL
      B4DT40
      Related
      ENSP00000444576.1, ENST00000543784.5
    17. NM_001400853.1NP_001387782.1  PCNA-interacting partner isoform 17

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882
    18. NM_001400854.1NP_001387783.1  PCNA-interacting partner isoform 18

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882
    19. NM_001400855.1NP_001387784.1  PCNA-interacting partner isoform 19

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882
    20. NM_001400856.1NP_001387785.1  PCNA-interacting partner isoform 20

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882
    21. NM_001400857.1NP_001387786.1  PCNA-interacting partner isoform 21

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882
    22. NM_001400858.1NP_001387787.1  PCNA-interacting partner isoform 22

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882
    23. NM_001400859.1NP_001387788.1  PCNA-interacting partner isoform 23

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882
    24. NM_001400860.1NP_001387789.1  PCNA-interacting partner isoform 23

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882
    25. NM_001400861.1NP_001387790.1  PCNA-interacting partner isoform 23

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882
    26. NM_001400862.1NP_001387791.1  PCNA-interacting partner isoform 24

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882
    27. NM_001400863.1NP_001387792.1  PCNA-interacting partner isoform 25

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882
    28. NM_001400864.1NP_001387793.1  PCNA-interacting partner isoform 26

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882
    29. NM_001400865.1NP_001387794.1  PCNA-interacting partner isoform 27

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882
    30. NM_001400866.1NP_001387795.1  PCNA-interacting partner isoform 28

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882
    31. NM_001400867.1NP_001387796.1  PCNA-interacting partner isoform 29

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882
    32. NM_001400868.1NP_001387797.1  PCNA-interacting partner isoform 30

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882
    33. NM_001400869.1NP_001387798.1  PCNA-interacting partner isoform 12

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882
    34. NM_001400870.1NP_001387799.1  PCNA-interacting partner isoform 12

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882
    35. NM_001400871.1NP_001387800.1  PCNA-interacting partner isoform 12

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882
    36. NM_001400872.1NP_001387801.1  PCNA-interacting partner isoform 32

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882
    37. NM_001400873.1NP_001387802.1  PCNA-interacting partner isoform 33

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882
    38. NM_001400874.1NP_001387803.1  PCNA-interacting partner isoform 34

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882
    39. NM_001400875.1NP_001387804.1  PCNA-interacting partner isoform 35

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882
    40. NM_001400876.1NP_001387805.1  PCNA-interacting partner isoform 36

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882
    41. NM_001400877.1NP_001387806.1  PCNA-interacting partner isoform 37

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882
    42. NM_001400878.1NP_001387807.1  PCNA-interacting partner isoform 38

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882
    43. NM_001400879.1NP_001387808.1  PCNA-interacting partner isoform 39

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882
    44. NM_001400880.1NP_001387809.1  PCNA-interacting partner isoform 40

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882
    45. NM_001400881.1NP_001387810.1  PCNA-interacting partner isoform 41

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882
    46. NM_001400883.1NP_001387812.1  PCNA-interacting partner isoform 42

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882
    47. NM_001400884.1NP_001387813.1  PCNA-interacting partner isoform 43

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882
    48. NM_001400885.1NP_001387814.1  PCNA-interacting partner isoform 44

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882
    49. NM_001400886.1NP_001387815.1  PCNA-interacting partner isoform 45

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882
    50. NM_001400887.1NP_001387816.1  PCNA-interacting partner isoform 46

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882
    51. NM_001400888.1NP_001387817.1  PCNA-interacting partner isoform 46

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882
    52. NM_001400889.1NP_001387818.1  PCNA-interacting partner isoform 46

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882
    53. NM_001400890.1NP_001387819.1  PCNA-interacting partner isoform 47

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882
    54. NM_001400891.1NP_001387820.1  PCNA-interacting partner isoform 48

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882
    55. NM_001400892.1NP_001387821.1  PCNA-interacting partner isoform 49

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882
    56. NM_001400893.1NP_001387822.1  PCNA-interacting partner isoform 49

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882
    57. NM_001400894.1NP_001387823.1  PCNA-interacting partner isoform 49

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882
    58. NM_001400895.1NP_001387824.1  PCNA-interacting partner isoform 49

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882
    59. NM_001400896.1NP_001387825.1  PCNA-interacting partner isoform 50

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882
    60. NM_001400897.1NP_001387826.1  PCNA-interacting partner isoform 51

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882
    61. NM_001400902.1NP_001387831.1  PCNA-interacting partner isoform 52

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882
    62. NM_001400903.1NP_001387832.1  PCNA-interacting partner isoform 53

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882
    63. NM_001400904.1NP_001387833.1  PCNA-interacting partner isoform 54

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882
    64. NM_001400905.1NP_001387834.1  PCNA-interacting partner isoform 54

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882
    65. NM_001400906.1NP_001387835.1  PCNA-interacting partner isoform 55

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882
    66. NM_001400907.1NP_001387836.1  PCNA-interacting partner isoform 61

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882
    67. NM_001400925.1NP_001387854.1  PCNA-interacting partner isoform 56

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882
    68. NM_001400926.1NP_001387855.1  PCNA-interacting partner isoform 57

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882
    69. NM_001400927.1NP_001387856.1  PCNA-interacting partner isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882
      Consensus CDS
      CCDS81729.1
    70. NM_001400928.1NP_001387857.1  PCNA-interacting partner isoform 59

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882
    71. NM_001400929.1NP_001387858.1  PCNA-interacting partner isoform 60

      Status: VALIDATED

      Source sequence(s)
      AC079907, AC087882
    72. NM_017915.5NP_060385.3  PCNA-interacting partner isoform 2

      See identical proteins and their annotated locations for NP_060385.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame splice site compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC079907, AC087882
      Consensus CDS
      CCDS9090.2
      UniProtKB/Swiss-Prot
      B4E0Y0, Q05C00, Q499L8, Q4FZA0, Q4KMW7, Q6NSC6, Q6PJA1, Q86W36, Q9NWS1
      Related
      ENSP00000332915.3, ENST00000327680.7
      Conserved Domains (1) summary
      TIGR01074
      Location:172316
      rep; ATP-dependent DNA helicase Rep

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      102120183..102197520
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047429048.1XP_047285004.1  PCNA-interacting partner isoform X2

    2. XM_047429049.1XP_047285005.1  PCNA-interacting partner isoform X5

    3. XM_047429050.1XP_047285006.1  PCNA-interacting partner isoform X6

    4. XM_011538514.3XP_011536816.1  PCNA-interacting partner isoform X1

      See identical proteins and their annotated locations for XP_011536816.1

      Conserved Domains (1) summary
      TIGR01074
      Location:91235
      rep; ATP-dependent DNA helicase Rep
    5. XM_047429052.1XP_047285008.1  PCNA-interacting partner isoform X8

    6. XM_047429051.1XP_047285007.1  PCNA-interacting partner isoform X7

    7. XM_047429055.1XP_047285011.1  PCNA-interacting partner isoform X11

    8. XM_017019541.3XP_016875030.1  PCNA-interacting partner isoform X3

    9. XM_047429054.1XP_047285010.1  PCNA-interacting partner isoform X10

    10. XM_047429053.1XP_047285009.1  PCNA-interacting partner isoform X9

    11. XM_047429056.1XP_047285012.1  PCNA-interacting partner isoform X12

    12. XM_047429057.1XP_047285013.1  PCNA-interacting partner isoform X13

    13. XM_011538515.2XP_011536817.1  PCNA-interacting partner isoform X4

    RNA

    1. XR_007063095.1 RNA Sequence

    2. XR_007063096.1 RNA Sequence

    3. XR_007063097.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      102081315..102158656
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054372369.1XP_054228344.1  PCNA-interacting partner isoform X2

    2. XM_054372372.1XP_054228347.1  PCNA-interacting partner isoform X5

    3. XM_054372373.1XP_054228348.1  PCNA-interacting partner isoform X6

    4. XM_054372368.1XP_054228343.1  PCNA-interacting partner isoform X1

    5. XM_054372375.1XP_054228350.1  PCNA-interacting partner isoform X8

    6. XM_054372374.1XP_054228349.1  PCNA-interacting partner isoform X7

    7. XM_054372378.1XP_054228353.1  PCNA-interacting partner isoform X11

    8. XM_054372370.1XP_054228345.1  PCNA-interacting partner isoform X3

    9. XM_054372377.1XP_054228352.1  PCNA-interacting partner isoform X10

    10. XM_054372376.1XP_054228351.1  PCNA-interacting partner isoform X9

    11. XM_054372379.1XP_054228354.1  PCNA-interacting partner isoform X12

    12. XM_054372380.1XP_054228355.1  PCNA-interacting partner isoform X13

    13. XM_054372371.1XP_054228346.1  PCNA-interacting partner isoform X4

    RNA

    1. XR_008488627.1 RNA Sequence

    2. XR_008488628.1 RNA Sequence

    3. XR_008488629.1 RNA Sequence